ALCOHOL USE DISORDER

This study tests a medicine called brenipatide to see if it helps adults with alcohol use disorder drink less and reduce cravings. About 1,100 people will take either the drug or a placebo for 56 weeks. The goal is to find a safe, effective treatment to help people cut down or st…

This study tests whether adding a brief family-involved treatment (B-FIT) delivered via telehealth can help veterans with alcohol use disorder drink less and improve family relationships. About 400 veterans and a family member or friend will take part. The goal is to see if this …

This study tests whether tirzepatide, a drug used for diabetes and obesity, can reduce heavy drinking in people who have both schizophrenia and alcohol use disorder. About 108 participants will receive either tirzepatide or a placebo for 16 weeks. Researchers will also use brain …

This study tests whether guanfacine, a medicine used for high blood pressure, can help people with alcohol use disorder drink less. Two hundred adults who want to quit drinking will take either guanfacine or a placebo for 12 weeks. Researchers will track drinking days, blood alco…

This study tests if a smartphone app called CHESS Health Connections can help people with alcohol-related liver disease stop drinking. About 298 participants from two medical centers will use the app for up to 6 months, and researchers will track their alcohol use and overall hea…

This study tests a cognitive behavioral therapy group designed specifically for women veterans who have alcohol use disorder or risky drinking habits. The goal is to see if this tailored approach helps reduce drinking and improve overall well-being. Researchers will enroll 162 wo…

This study tests whether a weekly injection of tirzepatide can reduce heavy drinking and improve health in 42 adults who have both alcohol use disorder and overweight or obesity. Participants will receive either the drug or a placebo for 8 weeks. The main goal is to see if the dr…

This study tests if a computer-delivered therapy can help people who have both an anxiety disorder and alcohol use disorder. The program aims to reduce heavy drinking days and delay relapse. Researchers will enroll 256 adults in an addiction treatment program to see if the comput…

This study tests whether a non-invasive device that stimulates the vagus nerve can reduce anxiety, withdrawal symptoms, and cravings in veterans with alcohol use disorder. About 80 veterans will receive the treatment, and researchers will measure changes in mood, quality of life,…

This study looks at why young adults with bipolar disorder are more likely to develop alcohol use disorders. Researchers will use brain imaging and alcohol response tests to track changes over two years in 100 people aged 21-26, half with bipolar disorder and half without. The go…

This study follows up to 7,500 adults with and without alcohol use disorder to collect health, genetic, and brain imaging data. It aims to better understand the condition and identify participants for future treatment studies. Participants may join as healthy volunteers, those no…

This study looks at whether having a trained peer recovery specialist in the emergency department helps people with substance use disorders connect to treatment and support. Researchers will follow 400 adults who came to the ER for a substance-related issue, comparing those who w…

This study screens up to 10,000 people aged 18 and older, with or without substance or alcohol use disorders, to see if they qualify for other NIDA research studies. Participants undergo a single visit with tests like physical exams, blood work, and memory assessments. The goal i…