ALCOHOL USE DISORDER

This study tests a telehealth program for people with alcohol use disorder. Participants either get the program right away or join a waitlist. The program includes doctor visits, medications, coaching, and a breathalyzer. The goal is to see if it helps reduce heavy drinking over …

This early-stage study tests whether a drug called apremilast can help people with Alcohol Use Disorder drink less alcohol. Ten adults will take the medicine and then have their drinking measured in a lab setting. The goal is to see if the drug reduces alcohol consumption, especi…

This study tests whether a medication normally used for other conditions can help people with HIV reduce their alcohol use. Thirty participants who have HIV, smoke, and drink heavily will receive the medication along with counseling. The goal is to see if this approach is practic…

This study tests whether online mindfulness classes help people with alcohol use disorder stay in recovery longer than online support groups. About 470 adults who want to cut back or stop drinking will take part. The goal is to see if mindfulness helps with long-term recovery and…

This study tests new technology-driven programs to help people with alcohol use disorder manage their drinking and well-being. The programs focus on personal goals and healthy behaviors. Researchers will see if these virtual tools help people start and stick with treatment and re…

This early-phase study tests whether a non-invasive brain stimulation technique called accelerated rTMS can help older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. The treatment aims to reduce heavy drinking and improve thinking skills by …

This study looks at whether citicoline, an over-the-counter supplement, can reduce inflammation and improve thinking in teens and young adults (ages 16-22) who drink alcohol. Participants will take either citicoline or a placebo pill for a period, and researchers will measure imm…

This study looks at whether offering alcohol use disorder treatment in Black churches helps more people start and stay in treatment compared to traditional specialty clinics. About 137 Black adults with alcohol use disorder will take part. The goal is to see which setting leads t…

This study tests whether giving small cash rewards for sober breathalyzer readings, submitted via a smartphone app, can help people with alcohol use disorder stay sober after leaving a detox program. Researchers will compare relapse rates and hospital readmissions between those w…

This study tests a stepped alcohol treatment program delivered via telemedicine for 180 adults with chronic liver disease who drink heavily. Participants are randomly assigned to either the program (motivational interviewing sessions plus possible referral to addiction medicine) …

This study tests whether a smartphone app and breathalyzer can help people with alcohol use disorder stay sober by rewarding them for not drinking. Participants use the app to take breathalyzer tests remotely, and those who stay abstinent receive money. The goal is to make this e…

This study tests a behavioral program called contingency management for people who have had a liver transplant due to alcohol-related liver disease and have started drinking again. Thirty participants will be randomly assigned to either receive the 10-week reward program (where t…

This study tests a program for couples where the young woman (15-24) has HIV. The goal is to help her stay on treatment by reducing her male partner's heavy drinking and the risk of intimate partner violence. About 80 couples in Uganda will try the program, and researchers will c…

This phase 2 study tests whether mazdutide, a drug originally developed for diabetes, can help people with alcohol use disorder drink less or stop drinking. About 300 adults with a current diagnosis will receive either mazdutide or a placebo for several weeks. The study tracks dr…

This study tests a counseling program called CAMI, which is a version of motivational interviewing adapted for Latino/a adults who drink heavily and may also use drugs. The program includes discussions about immigration-related stress. Researchers want to see if CAMI reduces heav…

This small study tests whether psilocybin or ketamine, combined with talk therapy, can help men aged 25-65 reduce heavy drinking. Participants must have moderate to severe alcohol use disorder and at least 4 heavy drinking days per month. The study tracks alcohol use and brain ch…

This study tests whether combining online sessions with in-person therapy helps people with alcohol use disorder stay in treatment longer and drink less. About 1,800 adults seeking public alcohol treatment in Denmark will take part. The goal is to see if this blended approach wor…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter recruits. About 480 trainees will take part in either an emotion regulation workshop or a standard education session during their aca…

This study explores whether a non-invasive brain stimulation technique called deep rTMS can help people with alcohol use disorder drink less. Researchers will target brain areas involved in memory and decision-making, which are often impaired in this condition. About 44 adults wi…

This study tests a cognitive behavioral therapy (CBT) group designed specifically for women Veterans who have alcohol use disorder. About 162 women will take part, and the therapy focuses on changing drinking habits and related behaviors. The goal is to see if this female-only ap…

This study tests whether a 6-week phone-based therapy (Acceptance and Commitment Therapy) can help young adults aged 18-25 in Hong Kong who drink heavily. 60 participants will either receive the therapy or supportive calls. The main goal is to see if the approach is practical and…

This study looks at whether oxytocin, a natural hormone, can boost the effects of a special talk therapy for veterans who have both alcohol use disorder and PTSD. About 175 veterans will get either oxytocin or a placebo along with therapy. The goal is to see if oxytocin helps the…

This early study tests whether brexanolone is safe and feasible for people who have both PTSD and alcohol use disorder. Researchers want to see if the drug can reduce stress-induced drinking. The study involves 25 adults aged 21-55 who drink heavily. It is a small, first-step tri…

This study tests whether taking a probiotic supplement for four weeks can help reduce alcohol cravings and improve thinking, mood, and gut health in people with alcohol use disorder. 38 participants are randomly assigned to receive either the probiotic or a placebo, and neither t…

This study tests a treatment called repetitive Transcranial Magnetic Stimulation (rTMS) to reduce alcohol cravings in veterans who also have mild traumatic brain injury or PTSD. Twenty veterans will take part; half will get real rTMS and half a placebo, with 10 sessions over two …

This study tests a smartphone-based program called LDART that uses social support to help adults with alcohol use disorder drink less. Researchers will enroll 80 people in Connecticut to see if the program is easy to use and helps reduce heavy drinking days. The goal is to gather…

This study looks at whether psilocybin, the active ingredient in magic mushrooms, can help people who have both major depression and alcohol use disorder. About 90 adults aged 21-65 will receive psilocybin in a controlled setting. Researchers will measure changes in depression se…

This small study explores whether two non-invasive methods—thinking about future events (Episodic Future Thinking) and low-intensity focused ultrasound—can reduce pain and alcohol cravings in people with both chronic pain and alcohol use disorder. Ten adults will complete tasks a…

This study tests whether a ketone supplement called Kenetik can reduce withdrawal symptoms in people undergoing alcohol detox. Fifty adults with alcohol use disorder will receive either the supplement or a placebo drink during their 5-day inpatient treatment. The goal is to see i…

This study looks at how alcohol use disorder and mild traumatic brain injury together affect the brain in veterans. The goal is to find a specific brain target that can be stimulated with a non-invasive technique called rTMS to improve daily functioning. About 100 veterans will t…

This study looks at how alcohol changes brain activity when people interact with each other. Researchers will use special brain scans (EEG) on pairs of people while they drink and do tasks. The goal is to understand the brain processes behind alcohol's social effects. 240 adults …

This study looks at 10,000 hospital patients with low sodium levels (hyponatremia) to find out how common it is, how fast it should be corrected, and what complications can arise, including brain damage. Researchers aim to improve treatment guidelines by tracking outcomes like de…

This study follows 250 adults with Alcohol Use Disorder who receive 12 weeks of talk therapy. Researchers track their drinking habits, dependence severity, and quality of life for a year after treatment. The goal is to better understand the different ways people recover and what …

This study is testing a new assessment tool to understand how brain function relates to drinking behavior in people with alcohol use disorder. Researchers will have 1,400 adults complete computer surveys and tasks measuring thinking, decision-making, and emotions. The goal is to …

This study follows 20 adults in Portland, Oregon, who are already receiving psilocybin services for alcohol use disorder. Researchers only observe and collect data—they do not provide any treatment. The goal is to see if psilocybin-assisted care reduces heavy drinking days over t…

This study follows 733 adults with alcohol use disorder to learn what helps them recover and what leads to relapse. Researchers measure thinking, social life, and drinking patterns over time. The goal is to find new ways to prevent relapse and support long-term recovery.

This study aims to find better ways to ensure veterans with PTSD, depression, or alcohol/opioid problems receive proven treatments. Currently, only 3-28% of patients get these effective therapies. Researchers will compare a participatory business engineering method (Participatory…

This early-phase study uses a special PET/CT scan and a radioactive tracer to measure inflammation in the brain and body of people with alcohol use disorder (AUD) compared to healthy volunteers. Up to 90 participants (60 with AUD, 30 healthy) will each receive one scan. The goal …

This study looks at how alcohol affects sleep in healthy women and men aged 21-45. Researchers want to see if women's sleep is more disrupted by alcohol than men's, and if the menstrual cycle phase plays a role. Participants will have sleep monitored in a lab after drinking alcoh…

This study looks at how to help primary care clinics screen more adults for substance use problems. It compares different support strategies like coaching, team learning, and financial rewards. 144 clinic staff from 48 practices will take part. The goal is to find the best way to…

This study looks at whether a single dose of diclofenac, a common pain reliever, can change a specific brain chemical in people with alcohol use disorder. Twelve adults with mild to severe alcohol use disorder will receive either diclofenac or a placebo in a double-blind fashion.…