ALCOHOL USE DISORDER

This early-phase study tests whether a non-invasive brain stimulation technique called accelerated rTMS can help older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. The goal is to see if the treatment can reduce heavy drinking and improve t…

This study tests whether giving small financial rewards for sober breathalyzer readings, collected remotely via a smartphone app, can help people with alcohol use disorder stay abstinent after detox. About 91 participants who recently completed detox will be monitored for several…

This study tests a behavioral program called contingency management for 30 liver transplant patients who have started drinking again. Half will receive rewards (up to $80 per week) for negative alcohol tests over 10 weeks, while the other half gets standard care. The goal is to s…

This study tests a new drug called sunobinop to see if it can help people with moderate to severe alcohol use disorder drink less. About 200 adults who want treatment will receive either the drug or a placebo. The main goal is to see if the drug reduces the number of days they ha…

This study tests a telehealth program for people with alcohol use disorder. Participants either get the program right away or join a waitlist. The program includes medical checkups, medications, coaching, videos, and a breathalyzer. The goal is to see if it helps reduce heavy dri…

This study looks at whether psilocybin, the active ingredient in magic mushrooms, can help people who have both major depression and alcohol use disorder. About 90 adults will receive psilocybin in a controlled setting to see if it reduces depressive symptoms and heavy drinking. …

This study looks at whether oxytocin, a natural hormone, can boost the effects of a special talk therapy for veterans who have both PTSD and alcohol use disorder. About 175 veterans will get either oxytocin or a placebo before therapy sessions. Researchers will track changes in d…

This pilot study tests whether a 6-week telephone therapy program (Acceptance and Commitment Therapy) can help young adults in Hong Kong reduce their alcohol use. 60 participants aged 18-25 who drink at hazardous levels will be randomly assigned to either the therapy group or a s…

This study is testing a new assessment tool called the ANA to better understand how brain functions relate to alcohol use disorder (AUD). Researchers will have 1,400 adults complete computer surveys and tasks that measure thinking, decision-making, and emotions related to drinkin…

This study looks at different methods to help primary care clinics screen adults for substance use problems. Researchers will compare coaching, learning groups, and financial rewards to see which works best. The study involves 144 clinic staff from 48 different practices.

This study follows 733 adults with alcohol use disorder to learn what helps people recover and what leads to relapse. Researchers measure thinking, social life, and drinking patterns over time. The goal is to find new ways to prevent relapse and support long-term recovery.