ALCOHOL USE DISORDER

This study tests a new, non-invasive brain stimulation technique called tTIS to see if it can reduce cravings and prevent relapse in people with alcohol use disorder. The treatment targets the amygdala, a brain area linked to cravings. Sixty adults aged 18-60 who meet the criteri…

This study tests whether combining counseling with a medication called cytisine helps people with HIV in Kenya quit smoking and reduce heavy drinking. About 300 participants will receive either counseling alone or counseling plus the medication. The goal is to improve long-term h…

This study looks at whether having a peer support specialist can help people who received a liver transplant due to alcohol-related disease. Researchers want to see if this support helps them stay away from alcohol, keep up with doctor visits, and live longer. About 95 adults who…

This study tests whether daridorexant, a medication that helps with sleep, can also reduce alcohol cravings and drinking in people with alcohol use disorder and sleep problems. About 150 adults will take the drug or a placebo and be monitored for sleep, cravings, and alcohol use.…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with severe alcohol use disorder reduce heavy drinking. Thirty-six adults who recently completed detox will be randomly assigned to receive either a full dose…

This study tests whether giving financial rewards based on a blood test can help people with alcohol-related liver disease stop or reduce drinking. The blood test detects alcohol use over the past month. Participants are randomly assigned to receive either escalating rewards for …

This study tests a coordinated care program for men with alcohol problems in primary care settings in Goa, India. About 1,022 men who drink heavily will be randomly assigned to either the program or usual care. The program uses different approaches depending on the severity of th…

This study tests whether semaglutide (a GLP-1 drug) plus counseling helps people with obesity, fatty liver, and alcohol use disorder stop drinking more than counseling alone. About 64 adults will take the drug or a placebo for 16 weeks. The goal is to see if the drug reduces alco…

This early study will test whether nimodipine, a drug usually used for blood pressure, can reduce alcohol drinking and cravings in heavy drinkers. Five adults with Alcohol Use Disorder will stay overnight at a hospital, take nimodipine, and then have the option to drink alcohol o…

This study tests whether adding a cognitive training program to standard addiction treatment can improve overall self-confidence in people recovering from alcohol use disorder. Researchers will enroll 130 adults who have been abstinent for 1 to 4 weeks and have mild cognitive dif…

This study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also attend weekly E…

This study looks at whether a nutritional ketone supplement can alter how the brain uses energy and reduce alcohol consumption in people with alcohol use disorder. Sixty adults who drink heavily but are not seeking treatment will receive either the supplement or a placebo, then u…

This study looks at how personal traits like anxiety, self-esteem, and perfectionism affect the ability to adapt to change in people with alcohol use disorder. About 30 participants will complete a computer task and questionnaires in one 45-minute session. The goal is to better u…

This study aims to adapt a proven suicide prevention program for people with alcohol use disorder in Tanzania, where mental health resources are scarce. Researchers will enroll 30 adults who drink heavily and have had recent suicidal thoughts, then test whether the telehealth int…

This study looks at how inflammation in the body might influence alcohol cravings and mood. Researchers will give a small dose of a substance that causes temporary inflammation to 64 people—half with alcohol use disorder and half without. They will then measure mood, cravings, an…

This study looks at how the liver heals from fatty buildup caused by heavy drinking. Researchers will take small liver samples from 25 adults when they enter a detox program and again after four weeks of not drinking. By comparing genetic activity in the liver at both times, they…