ALCOHOL USE DISORDER

This study tests whether the drug apremilast can help people with alcohol use disorder drink less. About 80 adults aged 21-65 will receive either apremilast or a placebo, and researchers will measure how much alcohol they consume during a lab drinking session. The goal is to see …

This study tests whether a drug called donepezil, combined with cognitive training (brain exercises), can help people with alcohol use disorder drink less heavily. About 160 adults aged 18-80 who currently have alcohol use disorder and have had at least one heavy drinking day in …

This study tests whether tirzepatide, a drug approved for weight management, can help people with alcohol use disorder and related liver disease drink less and improve liver health. About 120 adults aged 21 and older will receive weekly injections of tirzepatide or a placebo for …

This study tests a new medicine called brenipatide to see if it helps adults with alcohol use disorder drink less and reduce cravings. About 1,100 participants will receive either the drug or a placebo for 56 weeks. The goal is to find a safe and effective treatment to help peopl…

This study tests whether psilocybin or ketamine, given alongside therapy, can help people with moderate to severe alcohol use disorder drink less. Eighty adults will receive either a 30 mg dose of psilocybin or a 0.75 mg/kg dose of ketamine, plus psychotherapy. The main goal is t…

This study tests a short, computer-based program to help people with HIV and alcohol use disorder avoid returning to heavy drinking. About 150 adults from a Johns Hopkins HIV clinic will take part. The goal is to see if the program helps them stay alcohol-free longer and drink le…

This study tests whether a modified ketogenic diet (a low-carb, high-fat diet) can help people with alcohol use disorder reduce their drinking. Fifty adults with the condition will follow the diet and be monitored for cravings and alcohol intake. The goal is to see if changing wh…

This study tests whether blocking a brain chemical called orexin can reduce the urge to drink alcohol. Researchers will give 30 adults with moderate-to-severe Alcohol Use Disorder either an orexin blocker or a placebo, then measure how often they choose alcohol over money. The go…

This study tests a computer program that trains people with alcohol use disorder to avoid approaching alcohol-related cues. Researchers want to see if adding a simple planning step (called 'implementation intentions') makes the training more effective. 112 adults in treatment wil…

This study tests whether combining a gentle brain stimulation technique (tDCS) with cognitive training can help people with alcohol use disorder stay abstinent longer. About 40 participants who are already sober and in a treatment program will receive the paired therapy. Research…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with alcohol use disorder drink less. About 80 adults will receive either the drug or a placebo shot weekly for 5 months. Researchers will measure changes in drinking, brain activity, …

This study tests whether MDMA-assisted therapy can help veterans who have both PTSD and alcohol use disorder. Participants receive three monthly therapy sessions with either MDMA or a low-dose placebo, plus non-drug therapy. The goal is to see if this treatment reduces PTSD sympt…

This study is testing a medication called brexpiprazole to see if it can help people with alcohol use disorder drink less. Researchers want to know if a person's genes affect how well the drug works. The study involves 250 adults who are not currently seeking treatment for their …

This study tests a brief family-involved treatment (B-FIT) delivered via telehealth for veterans with alcohol use disorder. About 400 veterans and a family member or friend will take part. The program adds family support to standard therapy to help reduce drinking and improve fam…

This study tests a computer program called Approach Avoidance Training (AAT) for veterans with alcohol use disorder. The training aims to change unconscious urges to approach alcohol. Researchers will see if adding this to standard care helps 176 veterans reduce heavy drinking an…

This study tests whether the drug apremilast can reduce cravings for alcohol in people with moderate to severe alcohol use disorder. About 100 adults who want to cut back or quit drinking will take either a low or high dose of apremilast or a placebo daily for two weeks. Research…

This study tests an online program called Partners Connect for military couples where one partner drinks heavily. The goal is to see if the program helps the drinking partner cut back and encourages the service member to seek help. About 744 couples will participate, comparing th…

This study tests a new medicine called brenipatide to see if it helps people with moderate-to-severe alcohol use disorder drink less and reduce cravings. About 1,100 adults who want to cut down or stop drinking will receive either brenipatide or a placebo for 56 weeks. The main g…

This study tests whether taking a probiotic called Lactobacillus rhamnosus GG (LGG) for 6 months can help people with alcohol use disorder drink less and improve liver health. About 60 adults who are heavy drinkers will receive either LGG or a placebo. The goal is to see if the p…

This study tests a non-invasive brain stimulation technique called theta burst stimulation (TBS) to see if it can reduce heavy drinking and the brain's response to alcohol-related images. About 86 adults with alcohol use disorder will receive either real or fake TBS over the fron…

This study tests a new therapy called InTEGRA that combines 12-step support with motivational counseling to help teens aged 14-21 reduce alcohol and cannabis use. About 294 teens will be randomly assigned to InTEGRA or standard therapy. The goal is to see if InTEGRA leads to more…

This study tests whether offering specialized alcohol treatment right in the liver clinic helps people newly diagnosed with alcohol-related liver disease stop drinking. About 221 adults will be randomly assigned to either get the alcohol treatment offer or standard care. The main…

This study tests whether a smartphone app called CHESS Health Connections can help people with alcohol-related liver disease stay sober. About 298 participants will use the app along with their usual care for up to 6 months. The goal is to reduce drinking and prevent liver diseas…

This study tests whether guanfacine, a drug used for high blood pressure, can help 200 adults with moderate to severe alcohol use disorder drink less. Participants take the drug or a placebo for 12 weeks and report their drinking, stress, and cravings through a smartphone app and…

This study tests whether tirzepatide, a drug used for diabetes and obesity, can reduce heavy drinking in people who have both schizophrenia and alcohol use disorder. About 108 participants will receive either tirzepatide or a placebo for 16 weeks. Researchers will track changes i…

This study tests a non-invasive brain stimulation device called Deep TMS to see if it can help people with moderate to severe alcohol use disorder reduce heavy drinking. About 186 adults will receive either real or fake (sham) treatment over several months. The goal is to see if …

This study tests whether a weekly injection of tirzepatide, a drug used for diabetes and weight loss, can help adults with alcohol use disorder and overweight or obesity reduce heavy drinking. About 42 participants will receive either the drug or a placebo for 8 weeks. The main g…

This study tests whether full-spectrum cannabidiol (CBD) can help people who drink alcohol regularly reduce how much they drink. Researchers will track drinking behavior and blood markers over 12 weeks in 150 adults aged 21–65. The goal is to see if CBD offers a safe, non-addicti…

This study tests whether deep brain stimulation (DBS) can safely help people with severe alcohol use disorder who haven't gotten better with standard treatments. DBS uses small electrical signals to change activity in brain areas linked to craving and self-control. The study will…

This study tests whether a natural hormone called pregnenolone can help people with alcohol use disorder drink less. About 150 adults will take either pregnenolone or a placebo daily for 12 weeks. The goal is to see if the hormone reduces heavy drinking days and is safe to use.

This study tests a smartphone app designed to help people with both opioid and alcohol use disorders stay engaged in their recovery. Researchers want to see if the app is easy to use and if it helps people stick with their treatment. The study involves 50 adults in Michigan who a…

This study tests whether suvorexant, a drug used for insomnia, can help people with alcohol use disorder drink less. About 250 adults who want to cut back on alcohol will take the drug or a placebo nightly for 8 weeks. Researchers will track drinking habits, stress responses, and…

This early-stage study tests an experimental drug called NTX-2001 in 50 adults with Alcohol Use Disorder. Participants take the drug or a placebo daily for two weeks to see if it reduces alcohol consumption and is safe. The goal is to find a new treatment option for people who st…

This study looks at whether having regular motivational conversations after leaving the hospital for alcohol withdrawal can help people stay sober longer. About 104 adults who want to quit drinking completely will be split into two groups: one gets standard care, the other also g…

This study tests whether combining fMRI neurofeedback (brain activity training) and TMS (magnetic brain stimulation) can help people with alcohol use disorder drink less and feel fewer cravings. About 90 adults aged 19-65 who are already in treatment will attend weekly sessions f…

This study is testing a new treatment called IR-TMS, which uses magnetic fields to target specific parts of the brain, to see if it can help people with Alcohol Use Disorder reduce their drinking. About 150 participants will receive several sessions of this brain stimulation, alo…

This study tests whether a short, four-session therapy program that helps people rethink their identity and memories related to drinking can reduce alcohol use and cravings. Sixty adults with alcohol use disorder will be randomly assigned to either receive this therapy plus usual…

This study looks at how the drug acamprosate affects brain function in people with moderate to severe alcohol use disorder. Researchers will use EEG to measure brain waves in 48 adults who stay in the clinic for about 3 weeks. Half get acamprosate, half get a placebo, and brain a…

This study explores whether adding Acceptance and Commitment Therapy (ACT) to ketamine treatment is practical for 30 people who have both alcohol use disorder and depression that hasn't improved with standard medications. Participants will receive weekly ketamine infusions and AC…

This study tests a brief, virtual cognitive remediation therapy (Action-Based Cognitive Remediation) for young people aged 16-30 with early psychosis who also misuse alcohol or cannabis. The therapy aims to improve thinking skills and reduce substance use. Researchers will enroll…

This study tests whether immersive virtual reality (VR) nature experiences can reduce depression, anxiety, and stress in 50 adults with alcohol use disorder who are in an intensive outpatient program. Participants will use VR headsets to explore calming natural scenes alongside t…

This study tests whether a new therapy that combines cognitive processing therapy (for PTSD) with relapse prevention (for alcohol use) works better than relapse prevention alone. Researchers will enroll 200 adults with both PTSD and alcohol use disorder. The goal is to reduce dri…

This study tests whether a supervised exercise program can improve sleep quality in people with alcohol use disorder. Researchers will enroll 40 adults who have sleep problems and drink heavily. Participants will attend exercise sessions and track their sleep using diaries and wr…

This study looks at whether a special ketone drink can change how the brain responds to alcohol cues and reduce the urge to drink in people with alcohol use disorder. Twenty adults who drink heavily but are not seeking treatment will take part. On two separate days, they will dri…

This study tests a non-invasive device that stimulates the vagus nerve to help veterans with alcohol use disorder. The goal is to reduce withdrawal-related distress and cravings, and improve quality of life. Eighty veterans will receive the stimulation and be monitored for change…

This early-stage study tests whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may reduce harmful activity in the retina. The stud…

This study tests a small device that sends mild pulses to a nerve in the ear to help people with alcohol withdrawal symptoms. Twenty adults with alcohol use disorder will wear the device for 5 days during detox. Half will get real stimulation, half a placebo, to see if it reduces…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help people with alcohol use disorder drink less. Researchers will use brain scans to see how psilocybin changes the brain's response to alcohol cues. 200 adults will receive either psilocybin or a…

This study tests a digital program called RITch®CBT that uses an avatar to guide men through cognitive behavioral therapy for addiction. The goal is to reduce cravings and substance use while also addressing relationship conflict. Forty men entering addiction treatment will use t…

This study tests whether spironolactone, a drug already approved for high blood pressure, can help people with alcohol use disorder drink less. Twenty adults with AUD will take different doses of the drug or a placebo during four week-long clinic stays. Researchers will measure h…

This study tests whether a non-invasive brain stimulation technique called TMS can improve recovery for people with opioid or alcohol use disorder. Sixty adults in an intensive outpatient program will receive TMS alongside standard treatment. Researchers will measure changes in c…

This study tests whether a single dose of insulin given as a nasal spray can reduce cravings and the effects of alcohol in people with alcohol use disorder. Forty non-treatment-seeking adults will receive either insulin or a placebo spray, then be exposed to alcohol-related cues …

This study tests whether a ketone supplement drink can reduce alcohol withdrawal symptoms in 30 adults with moderate to severe alcohol use disorder during a 4-day hospital detox. Participants will receive either the ketone drink or a placebo, and researchers will measure how much…

This study tests if a computer-delivered therapy can help people who have both an anxiety disorder and alcohol use disorder. Participants will use an online program that teaches coping skills. The goal is to reduce heavy drinking and improve anxiety symptoms. If effective, this a…

This study tests a new drug called CMND-100 in healthy volunteers and people with alcohol use disorder. The goal is to find a safe dose and see if it can reduce drinking and cravings. About 84 participants will take part in this early-stage trial.

This study looks at how severe alcohol use disorder changes the brain's ability to understand emotions and social cues. Researchers will use brain scans and tests to compare 60 people with the disorder to healthy volunteers. The goal is to learn how these brain changes affect dai…

This study looks at how alcohol use disorder (AUD) changes a person's sense of taste and smell. Researchers will compare people with and without AUD using taste tests, smell tests, and brain activity measurements. The goal is to better understand these sensory changes, not to tes…

This study looks at how different activities and environments influence drinking habits and mental health in people with alcohol use disorder. About 44 adults will try virtual reality, games, or videos, then answer questions about cravings and alcohol use. The goal is to gather i…

This study is testing a new blood test to see if it can help doctors tell the difference between depression and schizophrenia, and whether it can show if a treatment is working. Researchers will collect blood samples and mental health surveys from 500 adults over three visits. Th…

This study looks at why people with alcohol use disorder feel anxious when they stop drinking. Researchers will use brain scans to compare people with AUD who take a medication to stay sober and healthy volunteers. The goal is to understand how anxiety changes over time during ab…

This study is testing whether a short, tailored alcohol intervention is practical and well-liked by people who are taking buprenorphine for opioid use and also drink alcohol. About 60 adults will take part. The goal is to see if this approach could work in a larger future study.

This study looks at how stress and oral health habits affect inflammation in the mouth and body of people with alcohol use disorder (AUD). Researchers will test a new questionnaire about dental care and collect saliva and blood samples from 72 participants, including healthy volu…

This study looks at what drives people with alcohol use disorder to drink. Researchers will ask 210 adults aged 21 to 65 about their mood, habits, and thinking, then give them alcohol through an IV and see how hard they work to get more. The goal is to understand how reward, emot…

This study screens up to 10,000 adults aged 18-99 who have current, past, or no substance or alcohol use disorders. Participants undergo one visit with tests like physical exams, blood work, memory tests, and mental health evaluations. The goal is to find eligible volunteers for …

This study looks at whether liver doctors can be trained to offer medication and brief counseling for alcohol use disorder during regular liver clinic visits. The goal is to make treatment more accessible for patients with both alcohol-related liver disease and alcohol use disord…

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with and without alcohol use disorders. Researchers will use MRI scans to see how the brain works during these tasks. The goal is to develop better tools for future st…

This study follows up to 7,500 adults with or without alcohol use disorder to learn more about the condition. Researchers will collect health information, blood samples, and brain scans to better understand the biology and genetics behind alcohol problems. The goal is to improve …

This study looks at why women are developing alcohol use disorder (AUD) faster than men. Researchers will measure brain activity and hormone levels in 100 adults to understand how self-control, emotions, and reactions to alcohol cues differ between sexes. The goal is to create be…

This study looks at medical records of 20 adults who had bariatric surgery and later received treatment for alcohol use disorder. Researchers want to understand how the surgery was considered during addiction follow-up. The goal is to improve care for patients with both condition…

This study looks at how men and women react differently to two weeks of not drinking alcohol. Researchers will measure alcohol intake, brain responses, and personal feelings after the break. The goal is to use this information to create better ways to prevent and treat alcohol us…

This early study is testing whether low-intensity focused ultrasound (LIFU) can safely change brain activity in people with alcohol use disorder. Researchers will scan participants' brains to see how reward centers respond to alcohol-related cues before and after the ultrasound. …

This study looks at how drinking too much and having posttraumatic stress disorder (PTSD) can lead to violence between partners. About 70 couples will take part in a lab test and answer daily questions for 28 days. The goal is to understand these links better, not to test a treat…

This study looks at how sleep patterns and stressful events influence alcohol use in young adults aged 18-24 who are heavy drinkers. Researchers will track sleep, brain activity, and stress responses to understand why some people drink more. The goal is to use this knowledge to c…

This study follows 400 adults who came to the ER for substance use issues. Some get help from a peer recovery specialist, others do not. Researchers will compare how many people start treatment, how their recovery progresses, and whether they need fewer ER visits over six months.

This study explores how transcranial magnetic stimulation (TMS) changes brain activity in people with and without heavy alcohol use. Researchers will use magnetoencephalography (MEG) to measure brain signals before and after TMS. The goal is to gather early data to support future…

This study tests whether an app-based alcohol intervention works as well as face-to-face counseling for people who drink heavily. About 1,200 adults in Mexico and South Africa who score high on an alcohol screening will either use an app or talk to a health educator. Researchers …

This study looks at a brain protein called PDE4B in people with alcohol use disorder. Researchers want to see if levels of this protein change during alcohol withdrawal and after a few weeks of not drinking. The study involves 30 adults who will have two PET brain scans and possi…

This study looks at 400 people with alcohol or cannabis use disorders to understand how their thinking, motivation, and emotions affect their recovery. Participants will have detailed assessments and then take part in a 12-week talk therapy program. The goal is to learn which tra…

This study looks at how impulsivity and the way young adults feel when drinking alcohol are connected. Researchers will track 250 people aged 21-25 who drink regularly, using lab tests and daily surveys. The goal is to find new ways to prevent and treat alcohol use disorder by ta…

This study looks at why young adults with bipolar disorder are more likely to develop alcohol use disorders. Researchers will use brain scans and alcohol challenges to track changes over two years in 100 people aged 21-26, half with bipolar disorder and half without. The goal is …

This small study is testing a new version of a counseling program called DeafMET, designed specifically for Deaf adults who use American Sign Language and have risky drinking habits. The goal is to see if the program is practical and helpful in motivating people to change their d…

This study looks at 350 hospitalized patients with alcohol use disorder to find patterns and risk factors that lead to relapse after detox. Participants fill out questionnaires, undergo evaluations, and take brain activity tests. The goal is to create a tool that gives feedback t…

This study looks at how changes in federal rules for opioid addiction medications (buprenorphine and methadone) affected treatment use and patient outcomes. Researchers will compare data from before and after these policy changes among veterans with opioid or alcohol use disorder…