Could a blood pressure drug curb alcohol cravings? new telehealth trial aims to find out

NCT ID NCT06629259

Recruiting now Disease control Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether guanfacine extended release (Intuniv), a drug currently used for ADHD and high blood pressure, can help 200 adults with moderate to severe alcohol use disorder drink less. Participants take either guanfacine or a placebo daily for 12 weeks, and report their drinking, cravings, and stress levels remotely. The trial is entirely telehealth-based, using a breathalyzer app and online surveys.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: guanfacine extended release (Intuniv)
What this could lead to: If successful, this could provide a new medication option to help people with alcohol use disorder drink less and reduce cravings.
What could go wrong: This is an early Phase 2 trial with 200 participants, so results may not apply to everyone. Guanfacine can cause side effects like low blood pressure, dizziness, and drowsiness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcohol abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE DISORDER

Contacts and locations

Locations

Rutgers School of Health Professionals
RECRUITING

Newark, New Jersey, 07107, United States
The Stark Neuroscience Building (Goodman Hall)
RECRUITING

Indianapolis, Indiana, 46202, United States

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