ALCOHOL USE DISORDER

This study tests whether semaglutide (a GLP-1 drug used for diabetes and weight loss) can help people with obesity and fatty liver disease reduce or stop drinking alcohol. 64 participants will receive either semaglutide injections plus lifestyle counseling, or counseling alone. T…

This trial tests a coordinated care program called CCAP for men with alcohol problems in primary care centers in Goa, India. The program includes mobile messaging for mild cases, counseling for moderate cases, and home detoxification with relapse prevention for severe cases. Over…

This study in Nairobi, Kenya, will test whether a drug called cytisine, combined with counseling, can help 300 people with HIV quit smoking and reduce heavy drinking. Participants will receive either cytisine or a placebo, plus either intensive counseling or standard advice. The …

This study tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) aimed at the amygdala, a brain region linked to cravings. Researchers will enroll 60 adults with alcohol use disorder to see if tTIS can reduce alcohol craving…

This study looks at whether having a peer support specialist can help people who received a liver transplant due to alcohol-related disease stay sober and keep up with their medical care. About 95 participants who have been alcohol-free for 1 to 3 years will be assigned to work w…

This study tests whether giving financial rewards based on a blood test can help people with alcohol-related liver disease stop or reduce drinking. The blood test detects alcohol use over the past month. 90 adults will be randomly assigned to either a rewards group that gets esca…

This study tests whether daridorexant, a medication that blocks certain brain signals related to wakefulness, can help people with alcohol use disorder who also have trouble sleeping. About 150 adults will receive either the drug or a placebo, and researchers will measure changes…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with severe alcohol use disorder reduce heavy drinking. Thirty-six adults who recently completed detox will receive either a high or low dose of psilocybin du…

This early study will test whether nimodipine, a drug usually used for blood pressure, can reduce alcohol drinking and cravings in heavy drinkers. Five adults with Alcohol Use Disorder will stay overnight at a hospital, take nimodipine, and then have the option to drink alcohol o…

This study tests whether adding a cognitive training program to standard addiction treatment can improve overall self-confidence in people recovering from alcohol use disorder. Researchers will enroll 130 adults who have been abstinent for 1 to 4 weeks and have mild cognitive dif…

This study tests whether a behavioral method called Emotional Brain Training (EBT) can help people in recovery from addiction manage stress, anxiety, and cravings. About 54 adults receiving standard addiction treatment will either continue their usual care or also attend weekly E…

This study looks at whether a nutritional ketone supplement can alter how the brain uses energy and reduce alcohol consumption in people with alcohol use disorder. Sixty adults who drink heavily but are not seeking treatment will receive either the supplement or a placebo, then u…

This study looks at how personal traits like anxiety, self-esteem, and perfectionism affect the ability to adapt to uncertainty in people with alcohol use disorder. About 30 adults receiving care at Paul Brousse Hospital will complete a computer task and questionnaires in one 45-…

This study aims to understand how inflammation in the body influences mood and alcohol cravings in people with alcohol use disorder (AUD). Researchers will give 64 participants (32 with AUD and 32 without) a single low dose of a substance that causes temporary inflammation or a p…

This study aims to adapt a proven suicide prevention program for people with alcohol use disorder in Tanzania, where mental health resources are scarce. Researchers will enroll 30 adults who drink heavily and have had recent suicidal thoughts, then test whether the telehealth int…

This study looks at how the liver heals from fatty buildup caused by heavy drinking. Researchers will take small liver samples from 25 adults when they enter a detox program and again after four weeks of not drinking. By comparing genetic activity in the liver at both times, they…