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Twins help scientists uncover brain inflammation link to obesity

NCT ID NCT07430852

Knowledge-focused Sponsor: University of Washington Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how genetics and what we eat might cause brain inflammation that leads to obesity. Researchers will study 110 identical twins who eat differently to see if their brains show signs of inflammation. The goal is to understand why some people gain weight more easily than others.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 110 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Apr 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 20-45 years * Differs in habitual diet from co-twin (study 1). * Willing to undergo 7-day overfeeding and hypocaloric feeding periods (study 2) * Member of the Washington State Twin Registry Exclusion Criteria: * History of bariatric surgery or active participation in weight-loss program * Major medical or neurological disorder (e.g., diabetes, multiple sclerosis) * Known gallbladder disease, anemia, impaired thyroid, kidney or liver function or hypertriglyceridemia (\>350 mg/dl) (study 2) * Current use of weight-loss medications or other medications known to alter appetite (e.g., atypical anti-psychotics) * High levels of vigorous physical activity (\>300 min./week) * Pregnancy, menopause, or breastfeeding * Individuals with severe food allergies and dietary restrictions (e.g., vegan/vegetarian, gluten-free, others) (study 2) * Co-twin unwilling or unable to participate * MRI contraindication (e.g., implanted metal, claustrophobia) * Lifetime eating disorder * Current smoking or heavy alcohol use (≥ 2 drinks per day for females and ≥ 3 drinks per day for males) * BMI \> 45 kg/m2 (study 1) * BMI \> 35 kg/m2 (study 2) * Weight \> 350 pounds or determined to be safe by MRI tech (MRI limit) * Inability to participate in a controlled diet program (study 2) or undergo other study procedures * Non-English speaking-or-reading individuals

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Conditions

The condition(s) this trial relates to.

Gliosis Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Genetics Obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Washington

    Seattle, Washington, 98109, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.