Could a diabetes drug and an antihistamine help repair MS nerve damage?
NCT ID NCT05131828
First seen Jan 09, 2026 · Last updated May 24, 2026 · Updated 19 times
Summary
This study tested whether combining two common drugs—metformin (for diabetes) and clemastine (an antihistamine)—can help repair the protective lining around nerve cells in people with relapsing-remitting multiple sclerosis (MS). The 70 participants continued their usual MS treatment while taking the drug combination or a placebo for 24 weeks. The goal was to see if the combination could improve nerve signaling and potentially slow or reverse disability.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Addenbrooke's Hospital
Cambridge, United Kingdom
Conditions
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