Zapping the brain to ease MS mental fog and mood
NCT ID NCT06401928
First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times
Summary
This study tested whether repeated electrical brain stimulation could improve mental health and cognitive function in people with multiple sclerosis (MS). Fifty-three adults with MS received either real or fake stimulation in a double-blind setup. Researchers measured changes in quality of life, sleep, mood, and thinking speed.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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53 people
The number who actually took part.
- Started
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Feb 2023
- Finished
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Jan 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. diagnosis of MS according to the diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria (Polman et al., 2011), certified by a professional neurologist 2. being 25-55 years old 3. providing written informed consent 4. If female, a negative urine pregnancy test 5. stable medication regime especially the classical neuroleptics and all CNS-activating medications, if taken, 4-6 weeks before the experiment and during the experiment 6. right handed Exclusion Criteria: 1. smoker 2. pregnancy 3. alcohol or substance dependence 4. history of seizure 5. history of other neurological disorders than MS 6. history of head injury 7. presence of ferromagnetic objects in the body that are contraindicated for brain stimulation of the head (pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips, metallic prostheses, permanent eyeliner, implanted delivery pump, or shrapnel fragments) or fear of enclosed spaces.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Multiple Sclerosis Association of Guilan
Rasht, Giulan, Iran
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Other studies related to the condition(s) this trial covers.
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