New hope for MS brain fog: personalized therapy shows promise

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants must have a confirmed diagnosis of Multiple Sclerosis (MS), as verified by a healthcare provider. * Participants should be in a relatively stable phase of their condition, not experiencing a severe relapse or acute health crisis at the time of the study. * Participants must have sufficient cognitive abilities to engage in therapy sessions, meaning they can follow instructions and perform the cognitive tasks required during the remediation program. * Participants must be able to effectively communicate in English, both verbally and in writing, to interact with therapists and complete assessments. * Participants must be adults aged 18 years or older. * Participants should have personal experience with cognitive challenges related to MS, such as problems with memory, attention, or problem-solving. * Participants must be willing and able to commit to attending all therapy sessions over the 12-week period, as well as attending assessments and completing any required homework or independent sessions. * Participants must provide informed consent, demonstrating that they understand the purpose of the therapy trial and are willing to engage in the course of cognitive remediation. * Participants must have access to a computer (laptop or desktop) for at least one hour per week during the treatment period (12 weeks). Exclusion Criteria: * Individuals who are currently receiving cognitive remediation or a similar intervention. * Individuals with high levels of depression, indicated by a score greater than 9 on the Patient Health Questionnaire-9 (PHQ-9). * Individuals with active suicidal ideation, indicated by a score greater than 0 on question 9 of the PHQ-9. * Individuals with a diagnosis of a psychotic disorder or bipolar disorder. * Physical disabilities that severely limit the individual's ability to attend therapy sessions or engage with the cognitive tasks (whether in-person or online) may lead to exclusion if suitable adaptations cannot be made.