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Scientists probe Sleep's role in MS fatigue and brain fog

NCT ID NCT07426991

Knowledge-focused Sponsor: Heinrich-Heine University, Duesseldorf Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how sleep issues contribute to tiredness and thinking problems in people with multiple sclerosis (MS). About 382 MS patients and a control group without MS will have overnight sleep tests, thinking assessments, and questionnaires. The goal is to better understand these links and use artificial intelligence to analyze sleep data, which could lead to better treatments in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 837 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be consecutively recruited at both study centers: the Department of Neurology at the University Hospital Düsseldorf and Kliniken Maria Hilf, Mönchengladbach. This collaboration combines the sleep medicine expertise of Kliniken Maria Hilf with the MS care expertise of University Hospital Düsseldorf, thereby providing optimal conditions to address the study objectives. Recruitment will additionally be supported by local neurologists in the Mönchengladbach region, who will establish initial contact between potential participants and the study centers. Informed consent will continue to be obtained by the study team.

Ages

18 to 79 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 and ≤ 79 years (all groups) * Adequate (corrected) hearing and vision to complete neuropsychological testing (all groups) * Sufficient proficiency in German to participate in assessments (all groups) * Capacity to provide informed consent and understanding of study procedures (all groups) * Diagnosis of MS according to the 2017 revised McDonald criteria (MS group) * Indication for sleep medicine evaluation due to at least mild fatigue, operationalized as ≥ 43 points on the Fatigue Scale for Motor and Cognitive Functions (FSMC) (MS group) * Indication for sleep medicine evaluation (control group) Exclusion Criteria: * Lack of signed informed consent or inability to provide consent (all groups) * Age \< 18 years or \> 79 years (all groups) * Presence of another neurological disorder in addition to MS, with the exception of migraine (all groups) * Use of medications that influence polysomnographic parameters (e.g., benzodiazepines) (all groups) * Uncorrected hearing or vision impairment and/or insufficient German language proficiency likely to impact neuropsychological test results (all groups)

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Conditions

The condition(s) this trial relates to.

chronic progressive multiple sclerosis Fatigue multiple sclerosis myalgic encephalomeyelitis/chronic fatigue syndrome primary progressive multiple sclerosis relapsing-remitting multiple sclerosis secondary progressive multiple sclerosis sleep-wake disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fatigue syndrome, chronic Multiple sclerosis Primary progressive multiple sclerosis Remitting-relapsing multiple sclerosis Secondary progress multiple sclerosis Sleep disorders

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Maria Hilf Clinics

    RECRUITING

    Mönchengladbach, 41063, Germany

  • University Hospital Düsseldorf

    RECRUITING

    Düsseldorf, 40223, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.