MS study probes hidden nerve damage to improve daily life
NCT ID NCT05748015
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how multiple sclerosis affects the autonomic nervous system, which controls automatic body functions like heart rate and sweating. Researchers will use skin biopsies and heart tests to measure nerve damage in 60 people with relapsing-remitting or primary progressive MS. The goal is to better understand symptoms like dizziness and temperature issues, and to see if different MS types have different patterns of nerve involvement.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to better management of symptoms like dizziness and temperature control in multiple sclerosis patients.
- What could go wrong
- This is an early observational study with only 60 participants, so findings may not apply to all MS patients and may not lead to new treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2021
- Expected to finish
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May 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * diagnosis of relapsing-remitting and primary progressive multiple sclerosis. Exclusion Criteria: * other forms of multiple sclerosis, * known other neurological disorders * assumption of potentially neurotoxic substances or drugs.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico II
RECRUITINGNaples, 80131, Italy
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ICS Maugeri - IRCCS of Telese Terme
RECRUITINGTelese Terme, Benevento, 82037, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Under-the-Skin MS drug: can a shot replace an IV drip?
- Can a common antihistamine boost multiple sclerosis treatment?
- Can exercise rebuild muscle and balance in MS?
- Can diet ease the crushing fatigue of multiple sclerosis?
- One-Time CAR-T infusion tested against progressive MS
- Can PET scans reveal hidden brain inflammation in MS?