Virtual worlds for real hands: MS patients test mixed reality therapy

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: -\>18 years of age. * Diagnosis of MS according to McDonald criteria (53) with a time of evolution longer than two years. * Assessment on the Kurtzke Multiple Sclerosis Disability Status Scale (EDSS) with a score between 2. 0 (minimal disability in one section of the FS (at least one with a score of 2).) to 7.0 (unable to walk more than a few steps, even with assistance, basically confined to wheelchair and able to transfer from wheelchair to another place, or can manage to go to the toilet for 12 hours a day) . * Stable medical treatment for at least six months prior to surgery. * Upper extremity muscle tone no greater than 2 points (moderate hypertonia, increased muscle tone during most of the arc of motion, but can passively move the affected part with ease) on the modified Ashworth Scale. * Muscle balance equal to or greater than 3 in the upper extremity. * Score less than or equal to 4 points on the "Pyramidal Function" section of the EDSS functional scale. * Absence of cognitive impairment, with ability to understand instructions and score equal to or greater than 24 on the Minimental Test. A- score equal to or less than 2 points on the "Mental Functions" section of the EDSS. Exclusion Criteria: * Diagnosis of a neurological disease or musculoskeletal disorder other than MS. * Diagnosis of a cardiovascular, respiratory or metabolic disease or other conditions that may interfere with this study. * Having suffered an exacerbation or hospitalization in the last 3 months before starting the assessment protocol, or during the therapeutic intervention process. * Having received a course of steroids, intravenous or oral, 6 months prior to the start of the assessment protocol and within the intervention period of the study duration. * Having received treatment with botulinum toxin in the 6 months prior to the start of the study. * A score higher than 2 points on the modified Ashworth scale. * Cognitive or language impairment that prevents adequate communication or comprehension. * The presence of visual disturbances not corrected by ocular devices; or a history of photosensitive epilepsy.