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Tiny brain signals may guide better seizure surgery

NCT ID NCT06105645

Knowledge-focused Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at whether measuring a specific type of brain wave called 'fast-ripples' can help surgeons do a better job treating drug-resistant epilepsy. About 440 patients will have brain monitoring with special electrodes before surgery. Half will have fast-ripple information used to plan their surgery, and half will not. The goal is to see if the fast-ripple group has fewer seizures one year after the operation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
DIXI Medical Microdeep® Micro-Macro Depth electrodes
What this could lead to
If successful, this could show that using fast-ripple information helps surgeons better identify and remove the seizure-causing brain tissue, leading to more patients being seizure-free after surgery.
What could go wrong
This is an early exploratory study, not a randomized trial. The benefit of fast-ripples is not yet proven, and the results may not apply to all epilepsy patients. There are also standard surgical risks like infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 440 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Apr 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient suffering from drug-resistant focal epilepsy (DRFE), as defined by the International League Against Epilepsy, undergoing SEEG, the indication of which was selected during a multidisciplinary epilepsy meeting * Patient who has given written informed consent to allow the study data collection procedures * Patient covered by the French healthcare system. Exclusion Criteria: * Patients under juridical protection (authorship, curators or safeguarding of justice). * Patient deprived of liberty by a judicial or administrative decision * Patient with a cardiac defibrillator * Thermocoagulation planned on one of the potential hybrid electrodes . * Patient in exclusion period of another study. * No other non-inclusion criteria since the study will only be proposed to patients who already meet the criteria for a SEEG

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Conditions

The condition(s) this trial relates to.

epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Epilepsy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    11 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • APHP Hôpital Bicêtre

    RECRUITING

    Le Kremlin-Bicêtre, 94270, France

  • CHRU de Nancy

    RECRUITING

    Nancy, France

  • CHU Amiens Picardie

    RECRUITING

    Amiens, France

  • CHU de Lille

    RECRUITING

    Lille, France

  • CHU de Rennes

    RECRUITING

    Rennes, France

  • Fondation Adolphe de Rothschild

    NOT_YET_RECRUITING

    Paris, 75019, France

  • Hospices Civils de Lyon

    RECRUITING

    Lyon, France

  • Hôpitaux universitaires de Strasbourg

    RECRUITING

    Strasbourg, France

  • University Hospital of Toulouse

    RECRUITING

    Toulouse, 31059, France

  • University hospital of Bordeaux

    RECRUITING

    Bordeaux, 33076, France

  • University hospital of Grenoble Alpes

    RECRUITING

    La Tronche, 38700, France

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