HIV

This study checked how well the Prevnar 13 (PCV13) vaccine works to prevent pneumonia and related infections in adults with HIV. Researchers looked at health records of over 350,000 people with HIV to compare those who got the vaccine with those who did not. The goal was to see i…

This early-stage trial tested a new HIV vaccine candidate in 57 healthy adults without HIV. The vaccine uses a protein designed to train the immune system to recognize HIV. The main goals were to check safety and see if the vaccine triggers a specific immune response. Results wil…

This study looked at how safe and tolerable the HIV drug dolutegravir is for newborns whose mothers have HIV. Researchers gave the medicine to 48 infants during their first month of life and monitored them for 16 weeks. The goal was to find a safe dose that works well alongside s…

This study tested different ways to deliver HIV treatment to people in South Africa who had a detectable viral load or were not engaged in care. The goal was to see which approach helped the most people achieve viral suppression at 18 months. The study enrolled 874 adults and com…

This study looked at whether adults aged 50 and older with HIV could safely switch from a three-drug pill to a two-drug pill (DTG/3TC) while keeping the virus under control. About 200 participants who already had undetectable virus levels made the switch. The main goal was to see…

This study tested two short programs for HIV-positive mothers and their children in China. One program focused on building resilience and coping skills, while the other helped with sticking to HIV medication. The goal was to see if these programs could improve their quality of li…

This study looked at how safe and effective the drug bedaquiline is for children and teens with a hard-to-treat form of tuberculosis (TB) that is resistant to the antibiotic rifampin. Fifty-four participants, some also living with HIV, received bedaquiline along with their person…

This study looked back at medical records of 800 adults with HIV to compare two drug combinations: a two-drug regimen (DTG/3TC) and a three-drug regimen (BIC/F/TAF). The goal was to see how well each kept the virus under control over 48 weeks. The study took place in multiple cli…

This study tested whether a weekly injection of PRO 140 could keep HIV under control in people whose virus was already suppressed by standard daily pills. 562 adults with a specific type of HIV (CCR5-tropic) switched from their usual combination therapy to PRO 140 alone for 48 we…

This study tested whether using genetic tests and blood drug levels to adjust HIV medication doses could improve safety and effectiveness. 190 adults starting HIV treatment in Argentina were randomly assigned to either standard dosing or personalized dosing. The goal was to see i…

This study tested a program called Family Connections for HIV-positive youth ages 15-21 and their caregivers in Zambia. The goal was to help teens achieve an undetectable viral load and reduce self-stigma through family support and education. Over 1,300 participants took part in …

This study tested a simple tool that helps doctors choose the best smoking cessation medications for their patients with HIV. 371 smokers living with HIV took part. The goal was to see if the tool helped more people quit smoking for at least 7 days.

This study tested a program called Abriendo Puertas (Opening Doors) for transgender women living with HIV in Santo Domingo. The program included individual counseling, peer support, and community activities to help women take their HIV medication regularly and keep the virus unde…

This study tested a program that combines group savings and loans with education on parenting, farming, and mental health support for people with HIV in Kenya. The goal was to help them stick to their HIV medication, lower stress, and achieve undetectable virus levels. Over 800 p…

This study tested a new medicine called LP-98, given as multiple injections under the skin, in 40 people with HIV who had never taken HIV drugs before. The main goal was to check if the injections are safe and how the body processes them. Researchers also looked at how well the d…

This study looked at whether people with HIV who have a low amount of virus in their body can safely switch from a three-drug treatment to a two-drug treatment. The goal was to see if the simpler treatment could still keep the virus under control while reducing side effects and c…

This small study tested whether adding the drug efavirenz to standard HIV treatment could safely reduce the amount of hidden virus in the body. Seven adults with HIV on stable therapy took extra efavirenz for a period. Researchers measured safety through blood tests and mood surv…

This study tested a program called iSTRIVE to help people with HIV who also use opioids or stimulants stay engaged in their HIV care. The program taught emotion regulation and communication skills, and included video check-ins for taking medication. The goal was to see if the pro…

This study tested a program where people living with HIV who use stimulants like methamphetamine could earn rewards for staying drug-free and taking their HIV medications. The program took place in a primary care clinic and used simple urine tests to check progress. The goal was …

This study tested a new medicine called Lipovirtide, combined with standard HIV drugs, in 64 adults with HIV who had never been treated before. The goal was to see if the combination could lower the amount of virus in the blood to very low levels. The study is complete, but resul…

This large study tested whether the statin drug pitavastatin could lower the risk of heart attacks, strokes, and other serious heart problems in people with HIV. Over 7,700 adults with HIV who were already on standard HIV treatment took either pitavastatin or a placebo pill. The …

This study tested a program where community health workers provided counseling, doctor visits, and phone calls to help people with both HIV and high blood pressure control their blood pressure. 100 participants in northern Tanzania took part over 6 months. The goal was to see if …

This study tested whether training healthcare providers to manage stress and reduce stigma could help people with HIV stay in care. Over 28,000 patients and staff at four health centers in Mozambique took part. The goal was to see if a low-cost program could improve patient reten…

This small study tested a group discussion program for men who have sex with men in South Africa who struggle to take their HIV medication (either daily prevention pills or treatment pills). The goal was to see if talking about common mental health problems could help them stick …

This study looked at whether dolutegravir, a newer HIV medicine, is safe and works well in pregnant women with untreated HIV. Sixty women in late pregnancy took either dolutegravir or standard HIV drugs. Researchers measured drug levels in the mothers and checked for side effects…

This study tested two quick screening tools for tuberculosis (TB) in 1,400 adults with symptoms like cough or fever. The tools—a chest X-ray analysis software and a blood test for inflammation—aim to rule out TB without needing lab tests. Results will help decide if these methods…

This study adapted and tested a community-based HIV prevention program for people who inject drugs along the U.S.-Mexico border. Researchers worked with 840 participants to understand how violence and stigma affect HIV risk and to tailor prevention efforts. The program included H…

This study tested a single pill called Delstrigo as a 28-day treatment to prevent HIV after a possible exposure. 399 adults who went to the emergency room for a potential HIV contact took the pill daily. The main goal was to see how many people finished the full 28-day course, an…

This study tested a new way to talk about HIV testing in Uganda. The messages focused on how testing can help keep relationships strong and families healthy, especially with the availability of PrEP (a medicine that prevents HIV). Over 7,600 people from two hospitals took part. T…

This study tested whether offering HIV prevention medicine (PrEP) right away at a syringe services program helps people stay HIV-negative. 90 adults who were already enrolled in the program and tested negative for HIV took part. Researchers measured drug levels in the blood to ch…

This study tested a new program called STARS for transgender women who have experienced intimate partner violence. The goal was to see if it could lower their risk of getting HIV by encouraging safer sex, PrEP use, and regular testing. Thirty-seven women took part, and the progra…

This study followed 240 young men who have sex with men for two years to help them stay on HIV PrEP and prevent sexually transmitted infections. Participants used a smartphone app to track risks and received counseling to avoid stopping PrEP early. The goal was to improve HIV and…

This study tested a digital health program for male couples to help them create personalized HIV and STI prevention plans and agreements. 778 couples joined, and researchers tracked changes in infection rates, communication, and commitment over 16 months. The goal was to see if a…

This study tested whether a program designed for Latino men who have sex with men could help them start taking PrEP, a daily pill that prevents HIV. 105 participants joined the study. The program was tailored to their culture and needs. The goal was to see if the program was easy…

This study tested a group program called PALMS (Preventing AIDS Through Live Movement and Sound) for African-American and Latino teen boys in juvenile justice or drug treatment centers. The goal was to see if it could reduce risky sexual behaviors and encourage HIV testing. The p…

This study tested different ways to offer HIV prevention pills (PrEP) at pharmacies in Kenya. Over 5,800 people took part across 60 pharmacies. The goal was to see if getting PrEP directly at the pharmacy, instead of being sent to a clinic, helps more people start and keep taking…

This study tested whether sending supportive messages via WhatsApp could encourage men who have sex with men in Mumbai and Thane, India, to get tested for HIV and connect with preventive services like counseling or PrEP. Over 1,000 participants joined the 18-month study. The goal…

This study tested a new oral medication, MK-8527, taken once a month to see if it is safe and tolerable for preventing HIV. The trial involved 352 HIV-negative adults at low risk of infection. Researchers monitored side effects and how the drug moves through the body, comparing i…

This study tested a smartphone app called SavvyHER designed to help Black women in the southern U.S. access HIV prevention tools and sexual health information. Fifty-six Black women aged 18-44 who were HIV-negative and sexually active took part. The goal was to see if the app was…

This study tested whether a tailored package of HIV prevention and treatment tools, delivered through community health programs, could lower new HIV infections in East Africa. Over 80,000 adults aged 15 and older took part. The approach focused on reaching people most at risk and…

This study tested a program called Couples Health CoOp Plus for young couples (ages 18-30) in Cape Town who use alcohol or drugs. The goal was to help them start and stick with HIV prevention (PrEP) or treatment (ART) while reducing stigma and risky behaviors. About 962 people to…

This study tested whether a mobile app called WeTest-WeLink could help more high-risk men in China test for HIV and connect to care. About 1800 HIV-negative men who have sex with men used the app or received standard information. The goal was to see if the app increased HIV self-…

This study looked at how to best give daily HIV prevention pills (PrEP) to pregnant women in Sub-Saharan Africa. Researchers tested different doses of the medication in 54 pregnant volunteers to find the dose that works best and is safest for both mother and baby. The goal is to …

This study tested two culturally adapted HIV prevention programs for African-born women living in the Boston and New York City areas. One program was one-on-one, the other was a group program. The goal was to see which approach works better at increasing condom use and PrEP use. …

This study tested a combination HIV prevention approach for 120 men in Kisumu, Kenya, who had recently exchanged sex for money or goods. Participants took daily PrEP pills and received real-time feedback from a urine drug test, HIV self-testing kits, and text reminders. The goal …

This study developed and tested a program to help Latino men who have sex with men get HIV prevention medication (PrEP), HIV testing, and mental health support. Researchers worked with 90 participants in the Miami area to see if the program improved their engagement with these se…

This study tested whether a program designed specifically for women who use drugs could help them reduce their risk of getting HIV and other sexually transmitted diseases. Over 500 women from the St. Louis area took part. They were split into three groups: one got basic HIV preve…

This study tested a package of services to help adolescent girls and young women in Zambia get regular HIV testing and stay connected to care. The program included wellness clinics and community youth clubs to educate and support girls and their families. Over 2,000 girls aged 10…

This study tested a 16-session online therapy program for transgender and gender-diverse people in Romania who have depression or anxiety. The therapy was designed to help with LGBTQ-related stress and improve mental health. 25 people took part, and researchers measured changes i…

This study tested whether a 12-week cognitive behavioral therapy (CBT) group program is practical and well-liked by older adults (50+) living with HIV. The program aimed to help participants better handle stress related to aging and HIV, and encourage healthy behaviors like physi…

This study looked at whether a 16-week program of aerobic and resistance exercise could improve heart and muscle health in 33 HIV-infected veterans aged 50 and older. Participants did treadmill tests and strength training to see if exercise could reduce chronic inflammation and p…

This small study tested whether a type of brain stimulation called TMS could reduce smoking cravings and attention to smoking cues in people living with HIV/AIDS. Four participants received either real or fake TMS sessions. The goal was to see if TMS could help them focus less on…

This study looked at how well the Pfizer COVID-19 vaccine triggered an immune response in 196 adults with weakened immune systems (like kidney transplant patients or those with cancer) compared to healthy adults. Researchers measured antibody levels in the blood and nose to see i…

This study looked at whether a program called Getting To Outcomes (GTO) helps community organizations deliver sexual health education to teens more effectively. Researchers worked with 909 youth aged 10-14 at Boys and Girls Clubs. The goal was to see if GTO improves staff skills …

This study looked for undiagnosed HIV in 300 hospital patients who had certain health conditions or behaviors that increase HIV risk. Researchers used a quick finger-prick test and a questionnaire to identify new cases. The goal was to find people who didn't know they had HIV so …

This study tested a tablet-based screening tool for substance use, depression, and anxiety in over 10,000 HIV-positive adults during routine clinic visits. The goal was to see if computerized screening could help more patients get the mental health and substance use treatment the…

This study tested a training program for labor and delivery providers in Tanzania to reduce HIV stigma during childbirth. The program used simulations and hands-on learning. Researchers compared how respectful care was before and after the training, based on reports from women wh…

This study looked at 200 adults with HIV in Liberia to compare two ways of checking for hidden tuberculosis (TB) infection: a skin test and a blood test. The goal was to see which test works better in this group. Participants had both tests and results were compared. This researc…

This study tested a 5-month group program called Sweekar to help transgender and gender-diverse people in Nepal overcome stigma and increase HIV testing and medication adherence. 31 participants joined group activities to address social stigma and learn about HIV prevention and c…

This study tested whether eHealth tools—like video calls, online monitoring, and messaging—can help families manage long-term childhood illnesses such as cancer, heart disease, and preterm birth. Researchers worked with 720 families in Sweden and Denmark to see if these digital a…

This study looked at HIV that stays hidden in the body even when the virus is under control. Researchers measured this 'latent reservoir' in 90 Ugandan adults with HIV. The goal was to learn more about the reservoir and compare it to what is seen in Western countries, which may h…

This study looked at whether it is safe for people with HIV to receive an organ transplant from a deceased donor who also had HIV. Researchers followed 13 HIV-positive transplant recipients to track their survival, organ rejection, and HIV progression. The goal was to gather info…

This study looked at whether offering HIV self-testing with online supervision helps young men who have sex with men (MSM) in Ho Chi Minh City get tested more often. One hundred participants aged 16-29 were enrolled. The goal was to see if this approach increases testing rates an…

This study tested whether having emergency room nurses experience an actual HIV test themselves could improve their knowledge about HIV testing and reduce stigma toward people living with HIV. About 74 nurses from a hospital in Taipei, Taiwan, were split into two groups: one grou…

This study looked at how cannabis affects thinking, balance, and walking in 25 older women, some with HIV and some without. Researchers gave participants either cannabis or a placebo and tested their walking speed, balance, and attention. The goal was to understand why cannabis u…

This study tested a simplified way of delivering HIV care to pregnant and postpartum women and their babies at a hospital in Kenya. The goal was to see if this approach could make clinic visits faster and more convenient while still keeping mothers healthy and preventing HIV tran…

This study looked at how five common HIV drugs enter breastmilk. Twenty healthy women at the end of breastfeeding took a single dose of one of the drugs. Researchers measured drug levels in blood and milk to see if concentrations could be harmful to infants or lead to drug resist…

This study tested whether offering small cash rewards ($25-$40) encourages more HIV testing among African American, Latina, and low-income women who face barriers to testing. Over 300 women from community organizations (like homeless shelters and domestic violence agencies) were …

This study asked 36 women aged 18-45 about their thoughts on using vaginal products to prevent HIV and other sexually transmitted infections. Participants filled out questionnaires about their sexual behavior and how often they would use such products. The goal was to gather opin…

This study collected tissue samples from tonsils, lymph nodes, intestines, and lungs of people with HIV and healthy volunteers. The goal was to measure the amount of virus and immune cells in these tissues. It helps researchers understand how HIV behaves in the body, but did not …

This study tested a program to help 219 incarcerated individuals with HIV, hepatitis C, or substance use disorder transition from prison to community healthcare. Participants worked with a nurse case manager before and after release to plan and coordinate their care. The goal was…

This study tested a new way to help women living with HIV get screened for HPV, a virus that can cause cervical cancer. The program used simple scripts and videos to address fears and stigma. Researchers measured how many women got screened and followed up after a positive result…

This study followed 215 people newly diagnosed with HIV in Hong Kong to see how often they developed non-AIDS conditions like high blood pressure, diabetes, bone thinning, and kidney problems. Participants were checked before starting HIV treatment and again after 48 and 96 weeks…

This study followed 1,377 people living with HIV in Liberia over three years to understand how the disease affects them. Researchers collected blood and urine samples, performed physical exams, and asked about health and behaviors. The goal was to gather information to improve HI…

This study followed 384 people with HIV who were already taking the medication TAF. Researchers wanted to see if measuring drug levels in dried blood spots could predict whether the virus stays suppressed. Participants had up to 3 visits over 48 weeks. The goal was to better unde…

This study involved 13 transgender women to see how Truvada® (a daily pill to prevent HIV) interacts with feminizing hormones like estrogen. Participants took Truvada® alone and then with added hormones, and researchers measured drug levels in blood and tissues. The goal was to f…

This study looked at 172 people with and without HIV to understand why those with HIV have a higher risk of diabetes. Researchers examined fat tissue and immune cells to see if chronic immune activation in fat contributes to insulin resistance. The goal was to gather knowledge, n…

This study enrolled over 1,100 people living with HIV whose current dolutegravir-based treatment was failing (viral load over 1,000 copies/mL). Researchers collected blood samples and sequenced the virus's entire genome to identify which drug-resistance mutations were present. Th…

This study followed about 1,900 pregnant women (some with HIV, some without) and their children for two years to see how HIV and the drug dolutegravir affect weight gain and body fat. Researchers measured things like weight, metabolism, and blood markers in both mothers and babie…

This study tested whether using augmented reality (AR) on a smartphone helps men who have sex with men (MSM) perform HIV self-tests more easily and confidently compared to using paper instructions. About 349 participants in Hong Kong were randomly assigned to use either an AR app…

This study looked at 227 HIV patients on antiretroviral therapy to see if poor oral health (like cavities and gum disease) is linked to metabolic problems and ongoing inflammation. Researchers measured dental health, bone density, and quality of life. The goal was to understand h…

This study tested whether a three-session couple-based program could improve quality of life and relationship satisfaction for male HIV serodiscordant couples (one partner HIV-positive, the other HIV-negative) in China. 88 couples participated, with half receiving the program and…

This study tested a peer education program where people already stable on methadone were trained to talk to friends in their social network who inject drugs, some of whom have HIV. The goal was to see if this approach could help more people enroll in drug treatment. The study enr…

This study tested whether an online mindfulness program is practical and well-liked by young gay, bisexual, and queer men at risk for HIV. The program aimed to help them cope with stress related to their identity and promote healthier behaviors. Researchers enrolled 68 participan…

This study created and tested a digital program for pregnant unmarried teenagers with HIV in Kenya. The goal was to help them deal with stigma and feel more confident telling a family member about their HIV and pregnancy. 169 teens and their caregivers took part. The results will…

This study tested a new rapid HIV test for infants and young children in Zambia to see if it helps more babies start treatment sooner. Researchers enrolled over 1,600 HIV-exposed children up to 17 months old. The goal was to measure how many infected infants began antiretroviral …

This study aimed to find better ways to manage high blood pressure in people living with HIV in South Africa. Researchers worked with over 4,300 patients and healthcare workers at nine clinics to understand barriers and test a new care approach. The goal was to improve blood pres…

This study tested whether an online mindfulness program is practical and well-liked by young gay, bisexual, and queer men at risk for HIV. Nineteen participants tried the program and gave feedback on how easy it was to use and how satisfied they were. The goal was to see if this …

This early-stage study tested a single injection of LP-98 in 36 healthy adults to see if it is safe and how the body processes it. The goal was not to treat or prevent HIV, but to gather initial safety data. Participants were closely monitored for side effects and changes in vita…

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with cancer or other chronic illnesses talk about their end-of-life care preferences. Participants filled out questionnaires and reviewed the document with a healthcare provider. Th…

This completed study tested 660 Ukrainian refugees in Slovakia for HIV, syphilis, hepatitis B, and hepatitis C using finger-prick rapid tests. The goal was to find out how common these infections are in this community and to connect those who tested positive with confirmatory tes…

This study tested whether a Buddhist mindfulness program could reduce the stigma felt by people living with HIV in Myanmar and Thailand. Nineteen HIV-positive participants took part, and researchers measured changes in stigma and quality of life. The goal was to understand how cu…

This study tested a program to help women living with HIV in Ghana use HPV self-sampling kits for cervical cancer screening. 108 women participated, and the researchers checked if they completed the self-sample and a Pap test after 6 weeks. The goal was to see if simple toolkits …

This study followed 450 transgender people (300 HIV-negative and 150 living with HIV) in Thailand, Vietnam, and the Philippines for two years. Researchers used surveys and lab tests to track new HIV cases, mental health, and social issues like stigma and discrimination. The goal …

This study looked at 171 people with HIV to see if insomnia makes pain worse and increases inflammation. Researchers measured pain sensitivity, sleep patterns, and blood markers. The goal is to confirm that treating insomnia could help reduce pain and inflammation in people livin…

This study tested whether a wrist alcohol biosensor and a smartphone app could help young adults (ages 18-29) with HIV track their drinking. 66 participants wore the sensor for 30 days and reported their alcohol use through an app. Some received extra engagement tools like person…

This study followed 56 people with HIV who were starting treatment for the first time. Researchers measured changes in body fat, heart function, and blood vessel health before and after starting HIV medications. The goal was to understand how HIV therapy might affect long-term he…

This study created and tested a short play (ethnodrama) to change how communities view young women who take PrEP, a daily pill that prevents HIV. Researchers worked with 63 people, including young women, their partners, friends, healthcare workers, and community leaders. Particip…

This study looked at 320 people with HIV in Chile, some with metabolic syndrome, to understand how ongoing inflammation affects their health. Researchers used advanced tools like single-cell sequencing and flow cytometry to analyze immune and inflammatory patterns. The goal was t…