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HIV study digs into hidden inflammation that drives Aging-Like diseases

NCT ID NCT07367867

Knowledge-focused Sponsor: Universidad de Magallanes Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 320 people with HIV in Chile to understand why they often develop health problems like heart disease and diabetes, even when their HIV is controlled with medication. Researchers collected blood samples and used advanced techniques to measure inflammation and immune system activity. The goal was to find patterns that could help predict and manage these long-term risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

320 people

The number who actually took part.

Started

Mar 2023

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Study population will be obtained from different centers from Santiago and Punta Arenas, including Fundación Arriarán, Hospital Clínico de Magallanes, Hospital del Salvador. These cohorts include men and women, from adolescence to adulthood and senior patients living with HIV under suppressive ART and presenting or not metabolic syndrome. A group of HIV negative individuals with and without metabolic syndrome will also be invited to participate to be used as controls when required.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: The following inclusion criteria will be considered in the adult cohort: * Adults over 18 years * Signed informed consent * HIV diagnosis confirmed by the Public Health Institute * Patients under clinical control in any of the participating centers * Availability to attend the taking of samples and medical controls The following inclusion criteria will be considered in the pediatric cohort: * Infants and children younger 18 years * Patients under control in any of the participating center * Signed informed consent by parents or legal guardians of the minor. In children 8 years and older, also informed assent * In infants under 4 months of life, HIV diagnosis by a first positive RT-PCR for HIV performed at the Public Health Institute. In infants and children over 4 months, HIV diagnosis is confirmed by the Public Health Institute. * Children exposed to HIV during pregnancy, labor or breastfeeding of mothers with confirmed HIV, with a negative diagnosis. * Availability to attend the taking of samples and medical controls, and without medical contraindications for taking the samples (severe anemia according to age). The following exclusion criteria will be considered in both cohorts: \- The only exclusion criterion will be the patient's refusal to participate in the case of adults and in the case of minors, the non-signature of the informed consent by the legal guardians and the minor's non-assent.

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome HIV infectious disease metabolic syndrome X

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Flow cytometry HIV Metabolic syndrome Microbiome Molecular biology Sequence analysis Single cell sequencing technology

Contacts and locations

Locations

  • Centro Asistencial Docente y de Investigación, Universidad de Magallanes

    Punta Arenas, Punta Arenas, 6200000, Chile

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