Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Gum health may influence HIV inflammation, study finds

NCT ID NCT04645693

Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 227 people with HIV who are on antiretroviral therapy. Researchers examined their oral health—including cavities, gum disease, and dry mouth—and checked for links to metabolic problems and ongoing inflammation. The goal was to understand if poor oral health contributes to long-term health issues in people living with HIV.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could highlight the importance of dental care in managing long-term health for people with HIV.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, only suggest links between oral health and inflammation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

227 people

The number who actually took part.

Started

Feb 2021

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients living with HIV above the age of 18 will be enrolled in this study.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Has been diagnosed with HIV (as documented by a prior laboratory report of positive HIV-1/2 antibody and/or detectable HIV RNA, available for review by the study team) * Has received antiretroviral therapy for at least 12 months * Able and willing to provide informed consent prior to initiation of study procedures * Willing and able to comply with all study procedures, and likely to be available for the duration of the study Exclusion Criteria: * Has been diagnosed with the following xerostomia-related autoimmune conditions: Sjorgen's and sarcoidosis * Has never received radiation therapy to the head or neck (including radioactive iodine therapy) * Was taking anti-osteoporotic agents (biphosphonates, denosumab) prior to HIV diagnosis. * Women who are pregnant at the time of enrollment.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Caries are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

dental caries HIV infectious disease Noncommunicable Diseases periodontal disorder Xerostomia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Caries HIV Non-communicable disease Periodontal diseases Xerostomia

Contacts and locations

Locations

  • University of Pennsylvania School of Dental Medicine

    Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.