University Of Pennsylvania

This study tests whether personalized marketing messages and discounts can encourage people with prediabetes or type 2 diabetes to switch from refined grains to whole grains when shopping for groceries online. About 216 adults aged 45-70 from the Philadelphia area who already sho…

This early-phase study tests a new treatment for a type of brain cancer (glioblastoma) that has come back after standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack the cancer. The main goal is to check the safet…

This study tests a program designed to help people with high blood pressure and high cholesterol lower their risk of heart disease. About 1,980 adults from Penn Medicine primary care clinics in West/Southwest Philadelphia and Lancaster will take part. The program uses tools and b…

This early-phase study tests a new treatment called TmPSMA-02 for men with metastatic castrate-resistant prostate cancer (mCRPC) that has not responded to standard therapies. The treatment uses the patient's own immune cells, modified to better target and attack cancer cells. The…

This study compares three standard treatments for people with isolated skin vasculitis, a condition where blood vessels in the skin become inflamed. The goal is to see which treatment works best to control symptoms and improve quality of life. About 90 adults will take part and b…

This study tests whether giving monthly cash payments to pregnant women with HIV in Botswana helps them better manage their health. Researchers want to see if the money improves their ability to stick to HIV medication and stay in care after giving birth. About 100 women will tak…

This early-phase study tests a new type of CAR T-cell therapy (huCART19-IL18-eDHFR) in 6 adults with follicular lymphoma that has returned or not responded to at least two prior treatments. The therapy uses a special imaging tag to track the cells in the body via PET/CT scans. Th…

This early study tests whether draining lymph fluid from the chest can lower harmful inflammation in people with septic shock. Ten adults in the surgical ICU will have a tube placed in their thoracic duct to drain lymph for up to 7 days. The goal is to see if this procedure is sa…

This early-phase study is testing a radioactive tracer called [18F]F-TMP to see how it spreads in the body and whether it can help detect bacterial infections using PET/CT scans. About 20 adults with known or suspected bacterial infections will receive the tracer and undergo imag…

This early-phase study tests a radioactive tracer called 11C-M503 to see if it can detect abnormal alpha-synuclein protein clumps in the brain, which are linked to Parkinson's disease and multiple system atrophy. About 70 adults aged 40-85 with Parkinson's, multiple system atroph…

This study is testing a new type of CT scanner that uses advanced photon-counting technology to create clearer images while using less radiation. Researchers want to see if it helps doctors better diagnose problems in the abdomen, chest, bones, and brain. About 250 adults aged 18…

This study tests whether amantadine, a drug used for other brain conditions, can improve recovery after a stroke. Sixty adults who had a mild-to-moderate stroke will receive either amantadine or a placebo for one month. Researchers will track side effects and use questionnaires t…

This study tests whether a ketone supplement drink can reduce alcohol withdrawal symptoms in 30 adults with moderate to severe alcohol use disorder during a 4-day hospital detox. Participants will receive either the ketone drink or a placebo, and researchers will measure how much…

This study tests if a home-based exercise program, guided by a smartphone and activity tracker, can help people who just got a mechanical heart pump (LVAD) become more active and improve their quality of life. About 100 adults with a new HeartMate 3 LVAD will either follow the ex…

This study tests whether adding game-like features and social support or competition can help people with a type of heart failure (HFpEF) become more physically active. About 270 adults will wear activity trackers and be placed in one of three groups to compare different motivati…

This study tests whether combining Transcranial Magnetic Stimulation (TMS) with speech therapy can improve language in people with mild aphasia after a stroke. About 24 adults who had a left-brain stroke at least 6 months ago will receive either real or fake TMS along with 10 day…

This study looks at whether a common injectable birth control, Depo-Provera, can help reduce the painful episodes that women with sickle cell disease often experience. About 65 adult women who have regular sickle cell pain will take part. They will first go through a 3-month peri…

This study tests whether adding pregabalin to the standard withdrawal drug lofexidine helps people with opioid use disorder feel less sick while quitting. About 150 adults who want to start long-acting naltrexone will take either the combination or a placebo for 8 days. The goal …

This study tests a new therapy that uses real-time brain scans (fMRI) to help people with major depression shift their attention away from negative thoughts. 80 adults aged 18-65 with depression will receive either real or fake neurofeedback while doing a task. The goal is to see…

This small pilot study is testing whether semaglutide, a drug used for diabetes and weight loss, is safe and tolerable for people with advanced lung disease. Eight participants with conditions like COPD or pulmonary fibrosis will take the drug for 12 weeks. Researchers will monit…

This study tests whether a numbing injection around knee nerves can quickly reduce pain in adults who come to the emergency room with knee pain not caused by injury. About 34 participants will receive either the nerve block or standard pain treatment. The goal is to see if the bl…

This study tests whether using social virtual reality (VR) during dialysis sessions can reduce loneliness and other symptoms in people with end-stage kidney disease. Sixty participants will use VR glasses for 30-45 minutes, three times a week, for four weeks. Researchers will com…

This study tests whether a 12-week Coping Skills Training program can reduce depression and anxiety in 750 people with COPD, especially those facing health disparities like low income or rural living. Participants attend weekly sessions and complete surveys. The program is compar…

This study looks at whether people with cystic fibrosis can collect sputum (mucus) samples at home and mail them in to detect lung infections as accurately as samples taken in a clinic. With newer treatments reducing mucus production, diagnosing infections has become harder. The …

This study aims to learn more about LCAT deficiency, a rare genetic condition that affects how the body processes fats. Researchers will collect medical records, blood and urine samples, and survey data from up to 40 participants to track how the disease progresses over time. No …

This early-phase study tests a new radioactive tracer called 11C-HY-2-15 to see how it spreads through the body and brain. The goal is to improve detection of abnormal alpha-synuclein protein in people with Multiple System Atrophy (MSA), Parkinson's disease, and progressive supra…

This study follows 100 people with relapsing polychondritis, a rare disease that causes repeated inflammation of cartilage in the ears, nose, and airways. Researchers will collect medical history and survey data to learn how the disease develops. The goal is to better understand …

This study is for adults with diabetes who need a kidney biopsy as part of their regular care. Researchers will collect kidney tissue, blood, urine, and genetic samples from 400 participants to compare those whose kidney function declines quickly versus slowly. The goal is to fin…

This study looks at how severe autoimmune blistering diseases like pemphigus and bullous pemphigoid are and how they affect quality of life. Researchers will enroll 150 adults to test disease severity scales and quality-of-life questionnaires. The goal is to create better tools f…

This study looks at how a part of the brain called the posterior cingulate cortex (PCC) helps us remember and make decisions. Researchers will record brain activity from 130 epilepsy patients who already have brain monitoring as part of their treatment. The goal is to understand …

This study is testing a new imaging drug called 64Cu-DOTA-ECL1i to see if it can show inflammation in the wall of the aorta in people with abdominal aortic aneurysms. About 30 adults with aneurysms and some without will get a PET/CT scan after receiving the drug. The goal is to u…

This study is testing whether a special breathing tube called a supraglottic airway can be used to help premature babies breathe right after birth. The study will include 20 premature infants born between 29 and 33 weeks who need breathing support. The goal is to see if this devi…