University Of Pennsylvania

This early-phase study tests a new type of CAR T-cell therapy (huCART19-IL18-eDHFR) in 6 adults with follicular lymphoma that has returned or not responded to at least 2 prior treatments. The therapy is designed to target cancer cells and includes a special tag that allows doctor…

This study tests whether starting non-invasive ventilation (a breathing machine) earlier than usual can help people with ALS. About 48 adults recently diagnosed with ALS will either start breathing support early or receive standard care. The goal is to see if early use improves q…

Some women feel severe pain during a C-section even with spinal or epidural anesthesia, which can lead to post-traumatic stress disorder (PTSD) after childbirth. This pilot study will test whether giving general anesthesia (being fully asleep) right away, compared to using pain-r…

This study aims to find the best time gap between taking two medications (mifepristone and misoprostol) to manage early pregnancy loss. About 1,000 participants will choose their own time interval, and researchers will track how well the treatment works, side effects, and patient…

This study looks at how lack of sleep and alcohol affect thinking and movement, similar to what astronauts might face in space. Fifty-six healthy adults aged 25-60 will stay in a lab for about 110 hours, go without sleep for 27 hours, and drink alcohol to a set level on another d…

This study will test a new, faster MRI scan designed to give clearer images of blood vessel walls. Researchers will compare the new scan to standard scans in 15 adults with blood vessel disease. The goal is to see if the faster scan works just as well, which could make future ima…

This study aims to understand how a non-invasive brain stimulation technique called TMS affects brain activity related to anxiety. Researchers will use brain scans to see how the stimulation changes brain responses in 140 healthy adults. The goal is to gather information that cou…

This study tests an imaging drug called 64Cu-DOTA-ECL1i to see if it can show inflammation in the aorta of people with abdominal aortic aneurysm. About 30 adults with the condition and healthy controls will get a PET/CT scan. The goal is to understand how inflammation relates to …

This study tests whether giving extra cash to low-income community college students helps them finish their degree or certificate and find better jobs. About 750 students in Omaha will be randomly chosen to receive the payments or not. Researchers will track their education, work…

This study looks at whether evolocumab, a drug that lowers bad cholesterol, changes the cells in the wall of an abdominal aortic aneurysm. About 44 people scheduled for aneurysm repair will get either the drug or a placebo before surgery. Researchers will then compare the tissue …

This study aims to improve how we measure NAD+, a molecule important for energy and aging, in healthy adults. Researchers will give participants a common supplement called nicotinamide riboside and use MRI scans along with blood and urine tests to see how NAD+ levels change. The …