University Of Pennsylvania

This early-phase study tests whether giving two immune-boosting drugs (LVGN7409 and a PD-1 inhibitor) before surgery can safely help the body fight HPV-negative head and neck cancer. About 27 adults with resectable tumors will receive the combination, then undergo surgery. The ma…

This study tests a device called OsciPulse that uses leg compression to reduce blood clot risk in people hospitalized after a stroke. About 40 adults with leg weakness will either get the OsciPulse or standard compression therapy. Researchers will measure changes in a blood marke…

This study tests a brain implant that sends electrical pulses to reduce loss of control eating in people with severe obesity. Six adults who have not been helped by other treatments will try it. The main goal is to check safety and see if it cuts down on binge episodes.

This study looks at whether a special type of PET scan (FDG-PET) can more accurately detect bone infections (osteomyelitis) in people with diabetic foot disease. Researchers will compare the scan results with MRI and follow patient outcomes to see how well it works. The goal is t…

This study tests a small, portable MRI machine for scanning the brains of 100 adults with hydrocephalus or other neurological conditions. Participants get both the portable scan and a standard CT or MRI on the same day. The goal is to see if the portable device can reliably detec…

This study tests a program of balance and strength exercises, bladder training, and home safety checks in 375 women aged 70 and older who have urinary incontinence. The goal is to see if this approach reduces falls and improves bladder control compared to just giving them informa…

This study tests an accelerated brain stimulation method for people with depression that hasn't improved with standard treatments. Instead of the usual 6-week schedule, participants receive 10 sessions of magnetic stimulation each day for 5 days. The goal is to quickly reduce dep…

This study is testing a new type of prosthetic socket that can be adjusted as a child grows, avoiding the need for frequent replacements. About 28 children aged 3 to 18 with limb loss will first help develop the design in the lab, then try it at home for two months. The goal is t…

This study tests whether a ketone supplement called Kenetik can reduce withdrawal symptoms in people undergoing alcohol detox. Fifty adults with alcohol use disorder will receive either the supplement or a placebo drink during their 5-day inpatient treatment. The goal is to see i…

This study follows 755 children who were in the pediatric intensive care unit (PICU) for the first time. Researchers want to learn about the physical, mental, and thinking problems that can happen after a serious illness. By tracking kids and their families over time, the goal is…

This early-phase study tests whether a new type of PET scan can measure inflammation in the brains of people with Parkinson's disease. Researchers will compare scans from 11 participants (both with Parkinson's and healthy volunteers) to see if the imaging drug 18F-NOS can help di…

This study looks at two different ways to encourage doctors to refer patients with high cholesterol to a centralized pharmacy service for statin management. About 1,950 patients who are not on the right statin dose will be included. The goal is to see which method works better at…

This study looks at how noise from airplanes affects people's sleep. About 400 volunteers living near airports will wear a small device that tracks heart rate and movement for 5 nights, while a recorder captures indoor sounds. They will also fill out morning surveys about their s…

This study looks at a program that helps people caring for a loved one with dementia. Researchers will interview 350 caregivers to see if the program reduces stress and improves their experience. The goal is to understand how well the support program works.

This study collects lymph fluid from the chest of 24 people (some with MS, some healthy) to compare immune cells in the blood versus deep lymph system. In MS participants, researchers also look at how the FDA-approved drug ofatumumab changes these cells. The goal is to better und…

This study uses a special PET scan to measure tau protein buildup in the brains of 106 older adults, some with normal aging and some with mild cognitive impairment (MCI). The goal is to understand how tau relates to memory and brain structure changes, which could help tell apart …

This study tests whether a special PET scan (FLT PET/CT) can show changes in tumor activity in people with metastatic breast cancer that has spread beyond the liver and bones. About 20 participants will receive the drug ribociclib followed by ribociclib plus paclitaxel, and have …

This pilot study tests whether adding stigma-reduction counseling to standard depression treatment helps adults living with HIV in Malawi. Researchers will enroll 200 people with HIV and depressive symptoms at two district hospitals. The goal is to see if the program is acceptabl…

This study examines stored lymph node samples from 100 people in Botswana who had lymphoma between 2012 and 2017. Researchers want to see how often Epstein-Barr virus (EBV) is found in these samples, and whether HIV infection makes a difference. The goal is to better understand t…

This study looks at whether a special payment model helps doctors coordinate care better for people with breast, colon, or lung cancer getting chemotherapy. Researchers will compare costs, quality of care, and use of hospital services between two groups. The goal is to see if thi…

This study tests a new PET/CT scan that uses a tracer called 18F-FluorThanatrace to measure PARP-1 activity in breast cancer tumors. About 50 adults with known or suspected breast cancer will get one or two scans. The goal is to see how well the scan detects cancer activity and c…

This study places a rapid testing device in primary care clinics to help doctors quickly identify whether a cold-like illness is caused by a virus or bacteria. About 8,000 adults with symptoms like cough or runny nose will get a nasal swab, with results in 15 minutes. The goal is…

This study looks at whether custom-made videos can help people who had a stroke 1 to 10 years ago better understand their condition and feel more satisfied with their care. About 100 participants will use a video app and answer surveys after 7 and 90 days. The goal is to see if t…

This study tests a new type of PET scanner that can take pictures of most of the body at once, instead of just a small section. Researchers want to see how well this scanner works in healthy adults and people with memory problems. The goal is to gather information to improve futu…

This study aimed to see if using wearable devices and text messaging with game-like features could encourage older adults in the hospital to walk more. It was designed for patients with heart-related conditions. However, the study was withdrawn before any participants were enroll…