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Kidney tissue study aims to unlock secrets of diabetic kidney disease

NCT ID NCT02986984

Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is collecting kidney tissue, blood, urine, and genetic samples from 400 adults with diabetes who are already scheduled for a kidney biopsy. Researchers will compare people whose kidney function declines quickly versus slowly to find molecular clues. The goal is to better understand diabetic kidney disease and identify potential targets for future treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could reveal new targets for future treatments to slow kidney disease in diabetes.
What could go wrong
This is an observational study, not testing a treatment. It may not directly lead to new therapies, and results depend on careful analysis of complex data.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2016

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults (18 years of age and older) with diabetes who are scheduled to have a clinically-indicated kidney biopsy.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Type 1 and 2 Diabetes by American Diabetes Association (ADA) criteria * Willingness to comply with study requirements, including intention to fully participate in protocol-specified follow-up at a clinical study site * Able to provide informed consent * Adult participants * Planned medically indicated kidney biopsy, prescribed by a practicing nephrologist Exclusion Criteria: * End Stage Renal Disease (ESRD), defined as chronic dialysis or kidney transplant * History of receiving dialysis for more than 30 days prior to biopsy * Institutionalized * Solid organ or bone marrow transplant recipient at time of first kidney biopsy * Less than 3-year life expectancy * History of active alcohol and/or substance abuse that in the investigator's assessment would impair the subject's ability to comply with the protocol * Unable to provide informed consent * Evidence of active cancer requiring treatment, other than non-melanoma skin cancer

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Conditions

The condition(s) this trial relates to.

chronic renal failure syndrome diabetes mellitus diabetic kidney disease Disease Progression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetic glomerulosclerosis Diabetic nephropathies

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    13 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Albert Einstein College of Medicine

    ACTIVE_NOT_RECRUITING

    The Bronx, New York, 10461, United States

  • Columbia University

    ACTIVE_NOT_RECRUITING

    New York, New York, 10032, United States

  • Lehigh Valley Health Network

    RECRUITING

    Allentown, Pennsylvania, 18103, United States

  • Mount Sinai Hospital

    RECRUITING

    New York, New York, 10029, United States

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Ohio State University

    RECRUITING

    Columbus, Ohio, 43210, United States

  • Oregon Health & Science University

    RECRUITING

    Portland, Oregon, 97239, United States

  • Stanford University

    RECRUITING

    Palo Alto, California, United States

  • University of Arkansas for Medical Sciences

    RECRUITING

    Little Rock, Arkansas, 72205, United States

  • University of Michigan

    ACTIVE_NOT_RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of New Mexico

    RECRUITING

    Albuquerque, New Mexico, 87131, United States

  • University of North Carolina

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

  • University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • University of Southern California

    ACTIVE_NOT_RECRUITING

    Los Angeles, California, 90033, United States

  • University of Texas Health Science Center at San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

  • University of Virginia

    RECRUITING

    Charlottesville, Virginia, 22908, United States

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06510, United States

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