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Brain zaps may curb smoking cravings in HIV patients

NCT ID NCT05295953

Symptom relief Sponsor: Gopalkumar Rakesh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether a non-invasive brain stimulation technique called TMS could reduce smoking cravings and attention to cigarette cues in people living with HIV/AIDS. Four participants received either real or sham TMS sessions. The goal was to see if TMS could help them focus less on smoking triggers and feel less urge to smoke.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcranial magnetic stimulation (TMS)
What this could lead to
If it works, this could point toward a new way to help people with HIV/AIDS quit smoking by reducing cravings.
What could go wrong
This was a very small early study with only 4 participants, so results may not apply to others. It only measured short-term effects on cravings and attention, not actual quitting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

4 people

The number who actually took part.

Started

Apr 2022

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Potential participants will be * Patients enrolled in the Bluegrass Clinic * 18-60 years of age * Male or female gender * Able to read, understand and communicate in English * Willing to adhere to the general rules of the Bluegrass Clinic/SMARTClinic/Beyond Birth Clinic * Willing and able to abstain from drug use other than Suboxone * Exhaled breath on day of study carbon monoxide (CO) \< 5 ppm * Stabilized on maintenance buprenorphine if having comorbid opioid use disorder. Exclusion Criteria: * Positive pregnancy test for females, traumatic brain injury, history of seizure disorder, history of or current diagnosis of schizophrenia, intracranial metal shrapnel. * Previous adverse effect with TMS. * Sub-threshold consistency while performing behavioral tasks. * Failure to show baseline attentional bias to smoking versus neutral cues.

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Conditions

The condition(s) this trial relates to.

AIDS HIV infectious disease Tobacco Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV Tobacco smoking

Contacts and locations

Locations

  • 245 Fountain Court

    Lexington, Kentucky, 40513, United States

  • University of Kentucky

    Lexington, Kentucky, 40513, United States

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