HIV

This early-stage study tests two new mRNA vaccines designed to help people with HIV produce antibodies against the virus. About 42 adults with well-controlled HIV will receive the vaccines and then temporarily pause their regular HIV medication under close monitoring. The main go…

This study tests whether alendronate, a drug used for bone health, can reduce the amount of hidden HIV in people who are already on standard HIV treatment. About 30 participants will be randomly assigned to receive either alendronate or a placebo, and neither they nor their docto…

This study tests whether a pharmacist-led electronic consultation can help people with HIV use their medications more safely and improve lung health. About 480 participants who smoke or take certain lung or stomach medications will receive tailored recommendations from pharmacist…

This study tests a new care model for veterans with opioid use disorder that combines infectious disease screening and treatment with their regular medication-assisted therapy in a single clinic visit. The goal is to make it easier for veterans to get tested and treated for infec…

This study tests whether trained peer navigators can help people living with HIV who also use substances stay connected to medical care and achieve viral suppression. Researchers will enroll 250 participants in Los Angeles County and track their HIV viral load, clinic attendance,…

This early-stage study tests an injection called JL18008 in HIV patients whose immune systems haven't fully recovered despite standard treatment. The goal is to see if it's safe and can improve immune function. About 52 adults aged 18-65 with well-controlled HIV but low CD4 count…

This study tests whether training pharmacy technicians can help more people with HIV get long-acting injectable medication at community clinics. About 465 participants will be observed or interviewed to see if this approach increases the number of people starting the shots. The g…

This study tests whether baricitinib, an anti-inflammatory drug, can keep HIV under control after participants stop their usual antiretroviral therapy (ART). Twenty people with well-controlled HIV will take baricitinib alongside ART for 26 weeks, then continue baricitinib alone f…

This study will test if a smartphone app can help people with HIV in Laos quit smoking better than printed materials. About 1200 smokers from 8 HIV clinics will take part. The app sends personalized texts, photos, and videos to support quitting. The goal is to see how many people…

This pilot study will test whether a program called Yuva Sath, led by trained peer counselors, can help young people (ages 18-29) who inject drugs in India stay engaged in addiction treatment and use HIV prevention services. Sixty participants will receive one-on-one sessions and…

This study looks at whether people with HIV who have stopped taking their medication for at least 12 weeks can safely restart the same day they return to care. About 200 adults will take the once-daily pill B/F/TAF. Researchers will check if the virus stays under control and if p…

This study tests a smartphone app called JomCare that provides timely support to men who have sex with men (MSM) to reduce chemsex—using drugs before or during sex—which raises HIV risk. About 482 HIV-negative or unknown-status men who have done chemsex in the past year will use …

This study will enroll 1,500 pregnant women with HIV in Uganda to find the best way to screen for tuberculosis (TB) and decide when to start TB prevention medicine. Researchers will compare symptom-based screening with a blood test and test starting prevention during pregnancy ve…

This study looks at whether intensive counseling, with or without a medication called cytisine, can help people with HIV quit smoking and cut down on heavy drinking. The trial will enroll 300 adults in Nairobi, Kenya, who smoke and drink heavily. The goal is to find better ways t…

This study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatments. The drug works by waking up tired immune cells. About 50 adults will receive the drug alongside the…

This study tests a program called Coach Mpilo, where men living with HIV are trained as peer coaches to help other men stay in HIV care and take their medication. The study will include 800 men in South Africa who have missed a clinic visit. The goal is to see if this peer suppor…

This pilot study tests a program for 40 adults recently released from jail who have a stimulant use disorder and are at risk for or living with HIV. The program combines a mobile app that rewards drug-free urine tests with a patient navigator who helps connect to HIV prevention o…

This study tests whether giving young people living with HIV a guaranteed income of $500 per month for 18 months helps them stay in care and achieve viral suppression. About 304 participants aged 18-35 who have faced financial hardship will be randomly assigned to receive either …

This study tests a special microscope that takes detailed pictures of cervical tissue right where the patient is, without waiting for a lab. About 400 women in Mozambique and Brazil who need a cervical biopsy or LEEP procedure will join. The goal is to see if this new method can …

This study aims to see if a personalized decision support tool can help people in emergency rooms and urgent care clinics start and continue taking PrEP, a daily pill that prevents HIV. The tool will address each person's medical and social needs to build confidence in using PrEP…

This study tests whether training young people to deliver HIV prevention medication (PrEP) to their peers increases its use. About 1,400 sexually active youth aged 15-24 in Brazil who are not currently taking PrEP will be randomly assigned to either peer-led community-based PrEP …

This study will test a smartphone app designed to help Black teenagers and young adults in Alabama stick with PrEP, a daily pill that prevents HIV. Researchers want to see if the app is easy and helpful to use, and whether it improves communication with a trusted adult supporter.…

This study tests a program that combines a mobile app with community delivery of PrEP (a medicine that prevents HIV) to help young people ages 13-24 stick with their prevention routine. Participants will receive PrEP at a convenient community location and use an app to support ad…

This study tests two smartphone tools to help HIV-negative men who have sex with men stick to their daily PrEP medication and reduce methamphetamine use. About 100 participants will use the apps or be placed on a waiting list, and researchers will check if the approach is practic…

This study tests ways to help more Black women get PrEP, a daily pill that prevents HIV. Researchers will work with 250 women at Planned Parenthood clinics in Illinois who have had a sexually transmitted infection. The goal is to make it easier for them to get a PrEP prescription…

This study tests a counseling program called Healthy Families-PrEP that helps women in rural Uganda use HIV prevention medicine (PrEP) while trying to get pregnant, during pregnancy, and after giving birth. About 660 women who are HIV-negative but at risk will take part. The goal…

This study tests a mobile app called PA-LINKS designed to help women who have recently been in jail or prison access HIV prevention (PrEP) and medication for opioid use disorder (MOUD). About 74 women will use the app and work with a navigator to connect to these services. The go…

This study will test a new digital teleconsultation program called E-PrevenT to help transgender sex workers and their clients get access to HIV and STI prevention services. The program aims to reach people who are often left out of traditional prevention efforts due to social an…

This study looks at whether offering HIV and STI testing as a standard, opt-out part of primary care visits—along with navigation to PrEP (a daily pill that prevents HIV)—increases how often these services are used. About 700 adults aged 18 to 45 at health centers in Mississippi …

This study aims to help 400 male commercial minibus drivers in Nigeria access HIV self-testing and long-acting injectable medications for both HIV treatment and prevention. The program uses peer educators from the driver community to promote these tools, making it easier for driv…

This study will offer young people aged 15-35 in Cape Town a choice of HIV prevention methods, including a new twice-yearly injection called lenacapavir, a two-monthly injection (cabotegravir), or daily pills. The goal is to see which option people stick with best and how to deli…

This study will test if a text-message program can help 18-22 year-olds in Uganda prevent HIV. Participants will receive interactive texts with quizzes, badges, and advice, and researchers will see if it increases HIV testing and condom use over 12 months. The goal is to find a l…

This study tests a mobile health program called PrEP Choice to help young people ages 13-24 start and stick with HIV prevention medication (PrEP). It also looks at whether taking a pill called doxycycline after sex (DoxyPEP) can prevent other sexually transmitted infections. Abou…

This study looks at whether offering HIV prevention medication (PrEP) during routine family planning visits works well for patients and doctors. About 83 patients and their physicians will take part. Patients will get counseling and can start PrEP if they want, then fill out surv…

This study tests a program called YACHT to help clinics in Florida better serve young men who have sex with men (YSMM). The goal is to increase HIV testing and improve referrals for PrEP, a medication that prevents HIV. About 210 clinics will take part, and researchers will check…

This study tests a virtual platform called LEARN 2 in 164 men aged 18+ living with HIV. The goal is to see if weekly online sessions and daily health tracking can improve quality of life and reduce risk factors for heart disease and metabolic problems. Participants are randomly a…

This study looks at whether adding a remote nurse via video call and text messages can help more people start and continue taking HIV prevention pills (PrEP and PEP) at pharmacies in Kenya. About 1,580 pharmacy clients will take part. The goal is to see if telehealth support make…

This study tests a program called CUPID that helps couples make decisions together about HIV prevention. About 1,400 women in Uganda will join with their male partners to choose and stick with prevention methods like PrEP pills, rings, or shots. The goal is to see if partner supp…

This study tests whether a smartphone app that plays personalized music can help people with HIV manage chronic pain. Sixty adults with HIV and ongoing pain will either use the app daily for 3 months or receive standard pain education. The goal is to see if the app is practical a…

This study tests whether metformin, a common diabetes drug, can help treat depression in people living with HIV. Depression is common in this group and can make it harder to stick with HIV treatment. The trial has three parts, starting with dose testing, then a placebo comparison…

This study tests if a brief, phone-delivered insomnia treatment (BBTI) can improve sleep and thinking in older adults with HIV compared to a mindfulness approach. 214 participants aged 50+ with insomnia will complete 4 weeks of therapy and be followed for a year. The goal is to s…

This study tests a program called HEATED-SAIA to increase HIV testing in emergency departments in Kenya. It focuses on reaching groups that often miss testing, such as men, adolescents, and key populations. The program uses a step-by-step approach to improve how HIV testing is of…

This study tests whether an automatic alert in electronic medical records helps doctors order screening tests for HIV, hepatitis B, and hepatitis C together. About 50 primary care providers will take part, and their patient visits will be randomly assigned to either see the alert…

This study will test a package of interventions designed to support nurturing care for children from birth to age 2 in Botswana, Kenya, and Zimbabwe. About 1,260 pregnant women, both with and without HIV, will be enrolled and their children followed for two years. The goal is to …

This study looks at whether offering teens private, confidential time with their doctor can increase HIV testing in pediatric clinics. Researchers will work with 4 clinics to see if this approach is practical and acceptable to staff and patients. The goal is to learn how to make …

This study tests whether a video-based app called "Undetectable & You" can help people with HIV in South Africa stay on treatment and keep the virus suppressed. The app explains that people with HIV who have an undetectable viral load cannot pass the virus to others (U=U). About …

This study will test two new services at a large Chicago health clinic: routine substance use screening for all patients, and a program that asks people to refer friends or partners who might need HIV or addiction support. The goal is to see if these methods help more people lear…

This study tests whether a short digital messaging program can help people who use drugs in Kazakhstan feel more ready to consider PrEP, a daily pill that prevents HIV. About 40 participants will receive educational messages via Telegram or WhatsApp over 2-3 weeks. The goal is to…

This study looks at whether reducing stigma in healthcare settings can help more providers offer, and more patients receive, important services for anal health, including STI testing, HIV prevention pills, and cancer screening. The research will take place in eight clinics in the…

This study aims to see if a special training program can help doctors in Vietnam treat people with HIV and men who have sex with men more fairly. About 155 medical providers will take part. Researchers will measure changes in how doctors offer tests and care to see if stigma decr…

This study tests an online program called eMPrISe for HIV-negative Latino men who have sex with men and use non-injection drugs. The program includes 12 weekly sessions to build coping skills and reduce meth use risk while improving steps toward taking PrEP, an HIV prevention pil…

This study works with 80 women with HIV in South Africa who have had an abnormal Pap smear. Researchers will interview patients and providers to understand why some women miss follow-up appointments. Based on what they learn, they will create a support program and test if it help…

This study aims to improve HIV outpatient care by routinely asking patients about their mental health, symptoms, and quality of life through a questionnaire called POSITIVE OUTCOMES. About 17,000 adults with HIV at five clinics in the UK and US will take part. Researchers will wo…

This study aims to reduce racial bias among pharmacy interns who may prescribe HIV prevention medication (PrEP). Researchers will adapt a bias-reduction program and test if it is acceptable and feasible for pharmacy interns. The goal is to improve care for people of color at risk…