HIV

This study tests whether extra COVID-19 vaccine doses can improve protection for people with weakened immune systems, including those with HIV, organ transplants, or blood cancers. About 960 participants will receive different booster schedules to see which works best. The goal i…

This early-stage study tests a new HIV vaccine in 36 healthy adults without HIV. The vaccine uses a two-step approach: first, a nanoparticle that displays HIV-like proteins, followed by an mRNA boost to strengthen the immune response. The goal is to see if this combination is saf…

This study tests whether giving higher doses of a TB drug (rifampicin) plus another antibiotic (levofloxacin) for 14 days, with or without steroids, can help more people survive. It includes 732 adults with HIV who are hospitalized for TB that has spread through the body. The goa…

This study tests a pharmacist-led program to help women with HIV who also face challenges like housing or food insecurity. The program uses telehealth to support switching from daily pills to a long-acting injectable treatment (shots every 2 months). The goal is to see if this ap…

This study tests a program to help 750 people with HIV in Botswana stop smoking. It uses counseling and a medication called varenicline. The goal is to improve health and reduce deaths caused by tobacco use in this group.

This study looks at whether giving HIV medicines to infected babies within the first week of life can reduce the amount of virus hiding in their bodies. The goal is to see if this early treatment helps their immune system fight the virus, possibly allowing them to stop medication…

This study tests four different programs to see which combination best helps young people (ages 11-17) with HIV in Uganda keep the virus under control. The programs include financial literacy training, savings accounts, a cartoon-based adherence and stigma reduction guide, and me…

This study tests whether a medication already approved for other uses can help people with HIV reduce their alcohol use. Researchers will work with 30 participants to see if the approach is practical, safe, and acceptable. The goal is to improve health outcomes by combining the m…

This study looked at three treatments for early HIV infection: zidovudine (AZT) alone, interferon alone, or both together. The goal was to see which best lowered the amount of virus in the blood, protected the immune system, and delayed serious infections. 180 adults with early H…

This early-stage study tests whether a person's own T-cells can be genetically modified to better recognize and attack HIV. Researchers will take blood from 12 HIV-positive participants, modify the T-cells in a lab, and then return them to the body. The main goal is to check safe…

This study looks at a rare, serious disease called KSHV-associated multicentric Castleman's disease (MCD), which is caused by a virus and often leads to death within two years. Researchers are testing several experimental drug combinations to control the disease and learning how …

This study tests whether giving an antimicrobial treatment to children recovering from severe acute malnutrition can reduce their risk of death, re-hospitalization, or failure to regain healthy weight. About 674 children aged 6-59 months who are hospitalized with complicated maln…

This study tests whether a 12-week home-based physical activity program, using a Fitbit and coaching sessions, can help people with HIV who drink heavily increase their daily steps and reduce alcohol consumption. About 222 participants will be randomly assigned to either the full…

This study tests whether a two-drug HIV pill (dolutegravir/lamivudine) works as well as a three-drug pill (bictegravir/emtricitabine/tenofovir alafenamide) for adults who have never taken HIV medication before. About 473 participants will take one of the two daily pills for up to…

This study tests whether a drug called N-803 (IL-15) can boost the immune system to control HIV without daily antiretroviral therapy. 20 adults with well-controlled HIV will receive the drug or placebo, then temporarily stop their regular HIV meds to see if the virus stays suppre…

This study tests whether combining urban gardening with peer nutritional counseling can improve HIV care for 433 adults in the Dominican Republic who have food insecurity. Participants must have detectable HIV viral load or adherence issues. The goal is to see if the program help…

This study looks at whether having a nurse case manager helps people with multi-drug resistant TB (MDR-TB) and HIV complete their long treatment. About 3,600 adults in South Africa are involved. Half of the clinics have a nurse case manager to guide patients, while the other half…

This study tests whether a 12-week combination of four drugs (bedaquiline, clofazimine, pyrazinamide, and delamanid) can treat drug-susceptible tuberculosis faster than the standard 6-month regimen. About 94 adults with active TB in the lungs will be randomly assigned to either t…

This study tests a program that trains pharmacists to help people living with HIV quit smoking. The program gives pharmacists tools and support to offer smoking cessation counseling and medications. Researchers will see if this approach helps more patients stop smoking and improv…

This study tests whether the antibiotic doxycycline can slow the worsening of emphysema in people living with HIV. About 133 current or former smokers aged 30 and older with HIV are taking doxycycline for 72 weeks. Researchers measure lung function, walking distance, and check fo…

This study tests whether offering prize drawings and motivational messages can help young people (ages 15-30) with HIV take their medication more consistently. 560 participants in Uganda will be split into groups with different incentive plans, all aiming for 90% adherence. The g…

This study tests a quick HIV test for newborns at high risk of getting HIV from their mothers. Babies who test positive are offered early treatment with the drug dolutegravir. Researchers will follow these babies for 96 weeks to see how well the treatment works and if it is safe.…

This study tests whether a combination of two drugs, dasatinib and quercetin (D+Q), can safely improve physical abilities in people aged 50 and older with HIV who are frail or prefrail. Participants take D+Q or a placebo in short cycles over 12 weeks, then are monitored for anoth…

This study looks at whether it is safe for people with HIV to receive a liver transplant from a donor who also had HIV. The main goal is to check for serious problems like organ failure, infections, or HIV complications. About 80 participants who already qualify for a liver trans…

This study tests a new gene therapy for people with HIV. Doctors take the patient's own blood stem cells, modify them to resist HIV, and give them back after a mild chemotherapy. The goal is to see if this approach is safe and can help control HIV without needing daily medication…

This study looks at whether a smartphone-based health platform (HMP) can help young sexual and gender minority (SGM) people aged 15-24 improve HIV prevention and care. About 1,500 participants will either get the HMP right away or after a delay. The goal is to see if the HMP incr…

This study tests whether helping HIV-positive teenagers in Uganda save money and start small income-generating projects can improve their adherence to HIV medication. 702 adolescents aged 10-16 are participating. The goal is to see if economic stability can be a key ingredient in…

This study tests a new approach called 'Data-to-Suppression' to help people with HIV who are not yet virally suppressed. It uses regular reports to identify those who need extra support and guides providers in offering targeted help. About 1,500 participants from low-income areas…

This study tests whether text message counseling can help women living with HIV make informed choices about contraception and pregnancy. About 3,310 women in Kenya who receive HIV care will take part. The goal is to see if mobile health tools improve the use of birth control and …

This study tests whether a special vaccine plus three lab-made antibodies can help people with HIV control the virus without taking daily antiretroviral therapy (ART). About 36 adults with well-controlled HIV will receive the vaccine and antibodies or a placebo, then temporarily …

This study tests whether baricitinib, a drug used for arthritis, can safely reduce the hidden HIV reservoirs in people whose HIV is already well-controlled with standard medication. Thirty adults with suppressed HIV will take either baricitinib or a placebo daily for 12 weeks whi…

This study tests whether adding special sugars found in breast milk (called human milk oligosaccharides) to the diet of HIV-exposed but uninfected infants can reduce infections and improve growth. About 140 babies will receive either the supplement or a placebo from 4 to 24 weeks…

This study tests whether a telemedicine program that combines brief counseling with cognitive-behavioral therapy can help people living with HIV reduce unhealthy alcohol use. About 308 participants in Alabama will receive either the combined program or brief counseling alone. The…

This study tests two ways to help teens with HIV stay in care and keep the virus under control. About 570 teens aged 15-19 in South Africa will get either in-person or virtual support as they move to adult care. The goal is to see which method works better for keeping clinic visi…

This study tests a once-weekly, 12-dose treatment for latent tuberculosis (TB) in children and teens with HIV. The goal is to see if it is safe and how it interacts with their HIV medication dolutegravir. About 92 participants aged 3 months to 17 years will be enrolled.

This study tests whether offering small prizes for completing job-search activities helps people with HIV find work faster. 144 unemployed participants will receive standard job services plus either encouragement alone or encouragement with chances to win prizes for 16 weeks. Res…

This study looks at whether people with HIV can get their long-acting injections at home instead of at the hospital. About 120 adults who are already stable on HIV medication will be randomly assigned to receive injections either at home or in the hospital. The goal is to see whi…

This study looks at whether using existing medications in a new way can help people with HIV who also have alcohol use disorder drink less. About 30 participants will receive the medication along with counseling and check-ins from a pharmacist. The goal is to see if this approach…

This study tests whether a smartphone game can help prevent HIV in young people aged 12-17 in Kenya. About 1000 teens and 500 parents will play the game, which teaches about safe sex, condom use, and avoiding risks. The goal is to see if the game helps teens delay sex and use pro…

This study enrolls 650 HIV-negative pregnant and breastfeeding women in South Africa who are at high risk of getting HIV. Researchers are testing a program that combines daily PrEP pills with extra counseling and community delivery for those who struggle to take the pills regular…

This study compares two ways of providing HIV prevention medication (PrEP) to young people in South Africa. One group gets PrEP through standard clinic visits, while the other group receives home delivery and support. The goal is to see which method helps more people start and co…

This study looks at whether a single dose of the HPV vaccine can prevent HPV infection in women living with HIV who have already been vaccinated. About 778 women are taking part, and half get the vaccine right away while the others wait. Researchers will track infections and side…

This study tests a program called Tu'Washindi, designed by and for young women, to help reduce intimate partner violence and increase use of the HIV prevention pill (PrEP). About 1,500 girls and young women aged 15-24 in western Kenya will take part. Half will get the program plu…

This study looks at whether getting the long-acting HIV prevention shot lenacapavir at a community pharmacy helps people stick with their PrEP routine. About 75 HIV-negative adults will receive the shot every 6 months and have either twice-yearly or quarterly pharmacy visits. Res…

This study aims to help more pregnant and postpartum women in Kenya get access to PrEP, a daily pill that prevents HIV. Researchers will work with 17,000 women and health workers in maternal clinics, using training and quality improvement tools to make PrEP services routine. The …

This study tests an online program called PATHS that helps parents talk to their gay or bisexual teenage sons about sexual health. About 350 parent-teen pairs join, with teens ages 14-19. Parents take a 45-60 minute online course, and teens report on condom use, HIV testing, and …

This study follows 100 cisgender women in the southern U.S. who are already prescribed long-acting cabotegravir (Apretude) shots for HIV prevention. Over two years, researchers will track how many women continue getting their shots on schedule and how satisfied they are with the …

This study tests two simple ways to help emergency room patients who are at risk for HIV get PrEP, a daily pill that prevents HIV. About 1,560 adults visiting the ER for sexual health concerns will be offered either a low-burden strategy to start PrEP right away or usual care. Th…

This study tests a new way to help teenage girls and young women in Kenya prevent HIV. It offers PrEP (daily pills or a vaginal ring) at local pharmacies, with extra support from nurse-navigators. About 1,900 participants will be followed for 10 months to see if they start and st…

This study tests whether mailing HIV self-test kits to men who have sex with men on a subscription basis encourages more frequent testing. 240 participants in Hong Kong will be reminded to test via text messages for part of the year, then receive actual test kits in the mail for …

This study works with primary care and reproductive health clinics to make it easier for women who inject drugs to get PrEP, a daily pill that prevents HIV. Researchers are training clinic staff and tracking how many women are screened and prescribed PrEP. The goal is to reduce n…

This study tests two counseling programs to help women who use drugs in Tanzania start and continue taking PrEP, a daily pill that prevents HIV. 200 women will be randomly assigned to receive either basic information, two counseling sessions, or up to 14 sessions that also addres…

This study is observing 127 people with HIV-related Kaposi sarcoma in Malawi and South Africa to see how their cancer responds to standard chemotherapy. Researchers want to find out why some patients do better than others, based on factors like gender and virus levels. The goal i…

This study follows 400 adults with HIV to learn how nonalcoholic fatty liver disease (NAFLD) progresses over time. Researchers use non-invasive scans to measure liver fat and stiffness at the start and after one year. The goal is to fill major knowledge gaps, since people with HI…

This study looks at whether a computer-delivered alcohol intervention plus help from a community health worker can reduce heavy drinking and improve HIV prevention in women. About 12 women who drink heavily and are either living with HIV or at high risk will take part. The goal i…

This study looks at how cannabis (specifically the drug Dronabinol) affects the immune system and genes in people with HIV. Researchers will take blood samples before and after giving Dronabinol to see changes in immune cells and inflammation. The goal is to better understand the…

This study looks at whether sending simple reminders (nudges) to doctors, patients, or both can increase the number of people with HIV who get help to quit smoking. About 500 patients and their doctors will take part. The goal is to see which approach works best to connect patien…

This study looks at whether a chatbot on WhatsApp can help adults in Nigeria who are newly diagnosed with HIV learn more about their condition. About 314 people will take part, with some using the chatbot plus standard care and others receiving only standard care. The main goal i…

This study looks at different ways to deliver HIV treatment and care in Zambia. Researchers want to see how these models affect patient health, satisfaction, and costs. About 8,280 patients and providers at 12 health facilities are taking part. The goal is to help policymakers ma…

This study tests a program called ePORTAL HIV-S to make it easier for people with HIV to get screened for substance use disorders. The program uses online patient portals and clinic-based screening, even when patients don't have a scheduled appointment. Researchers will track how…

This study looks at whether the amount of HIV in the blood of people on long-term antiretroviral therapy stays the same or changes over time. It also checks if the virus develops new genetic mutations while being suppressed. About 70 adults with HIV who have very low virus levels…

This study looks at different ways to deliver HIV treatment in Malawi to see which methods work best for patients and clinics. Researchers are surveying over 15,000 patients and providers at 12 health facilities. The goal is to help policymakers improve HIV care and make it more …

This study looks at how often fatty liver disease occurs in people living with HIV. Researchers will use a special ultrasound scan to measure liver fat in 1,250 adults with HIV who are on stable treatment. The goal is to fill a knowledge gap, since past studies on fatty liver hav…

This study looks at whether HIV disrupts the body's internal clock (circadian rhythm), which could lead to health problems like diabetes and heart disease. Researchers will measure gene activity at different times of day in 80 people with and without HIV. The goal is to understan…

This study looks at 40 people with HIV to see if a common drug called tenofovir causes more immune activation and helps the virus hide in the body. Researchers will compare those on tenofovir-containing treatments to those on other regimens. The goal is to understand how differen…

This study looks at how well a long-acting HIV treatment (given as shots every two months) works for people living far from big cities. About 55 patients and their clinic staff will answer surveys and interviews over 15 months. The goal is to understand what helps or hinders gett…

This study is testing a new tool called PATH that helps doctors check for age-related health problems in people with HIV who are 50 or older. The goal is to see if the tool is practical and acceptable for use in HIV clinics. About 60 participants from two clinics will take part, …

This study looks at how different models of HIV care (like community pick-up points or fast-track refills) affect patients and healthcare workers in South Africa. Researchers will survey over 15,000 people and observe clinic operations to understand what works best. The goal is t…

This study looks at a program to help caregivers tell children (ages 7-18) living with HIV about their diagnosis. The goal is to see if this approach improves the children's health and medication habits. About 747 children and their caregivers in Ghana are taking part.

This study asks about 1,100 HIV patients in South Africa what services they prefer during their first six months on antiretroviral therapy. Many patients drop out of care early, so researchers want to learn how to make treatment easier to stick with. The results will help design …

This study tests a program called Potlako+ that combines community education, help for healthcare workers, and patient guides to speed up cancer detection and treatment. About 874 adults in Botswana with possible cancer symptoms will take part. Half of the communities get the pro…

This study looks at how cannabis use changes the levels of HIV medications in the blood and brain, and whether it affects mood and thinking. It involves 120 people in an observation phase and 40 people in a phase where they receive cannabis or a placebo. The goal is to understand…

This study follows 830 women in Alabama to learn why some get HIV or sexually transmitted infections (STIs) and how to better use prevention tools like PrEP. Participants must be HIV-negative, have had a recent STI, and own a smartphone. The goal is to gather information, not to …

This study enrolls 50 people with HIV who previously received either a combination of two anti-HIV antibodies (bNAbs) or a placebo in an earlier study. Participants will temporarily stop their HIV medications so researchers can measure how quickly the virus returns and how high i…

This study looks at why people with HIV are more likely to develop fatty liver disease. Researchers think changes in gut bacteria might be a cause. They will test if taking probiotics and fiber can improve liver health in 63 participants.

This early-stage study tests whether spironolactone, a drug already approved for high blood pressure, can reduce the hidden HIV reservoir in people on effective antiretroviral therapy. Twelve adults (both HIV-negative and HIV-positive) will take the drug for a short time, and res…

This study aimed to see if changing the look and feel of HIV clinics in Uganda could reduce stigma and make patients feel more welcome. Researchers planned to update clinic systems and physical spaces to improve privacy and friendliness. However, the study was withdrawn before an…

This study will check how well the HPV vaccine works in women living with HIV and find better ways to screen for cervical cancer. About 650 women will use a self-testing kit at home, and those with positive results will get further exams. The goal is to improve health outcomes fo…

This study looks at how to get a proven depression care program (HITIDES) into VA clinics that treat veterans with HIV. The program is known to work well and save money, but no VA clinic currently offers it. Researchers will compare two approaches to help clinics adopt the progra…

This study looks at what services and support help people with HIV stay in treatment during their first six months on antiretroviral therapy (ART). About 771 adults in Zambia will share their preferences and needs through surveys. The goal is to design better care models that red…

This study tests whether adding stigma-reduction counseling to standard depression treatment helps adults living with HIV in Malawi. Researchers will enroll 200 people and measure if the approach is acceptable, feasible, and improves depression symptoms and HIV care engagement. T…

This study aimed to test a new system that adds tiny, edible silica particles to HIV pills. People living with HIV could use a smartphone app to scan the pills and automatically record when they take their medication. The goal was to see if the system is easy to use and accuratel…

This study will enroll 174 adults in New York City to see how well the mpox vaccine works in people with HIV compared to those without HIV. Researchers will test two ways of giving the vaccine: a low-dose shot in the forearm and a standard-dose shot in the upper arm. The goal is …