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Silent spreaders? study probes asymptomatic TB transmission

NCT ID NCT07312266

Knowledge-focused Sponsor: Barcelona Institute for Global Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether people with tuberculosis (TB) who have no symptoms can still pass the infection to others. Researchers will follow about 6,770 participants, including those with HIV, and use advanced genetic testing to track TB spread among close contacts. The goal is to better understand how asymptomatic TB contributes to the epidemic.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could show that asymptomatic TB plays a key role in spreading the disease, potentially reshaping how we control TB outbreaks.
What could go wrong
This is an observational study, not a treatment trial. It may not prove direct transmission, and results might not apply to all populations or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 6,770 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

May 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants attending routine HIV care at the Manhica District Hospital

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Index cases: Inclusion Criteria: 1. 18 years of age or older 2. Documented HIV infection 3. Presenting at a health facility for routine HIV care Exclusion Criteria: 1. History of TB treatment in the last 12 months 2. Pregnant women 3. Refusal to provide consent for study procedures 4. Contra-indication to any sampling procedure required by the study Study 3 will utilize additional inclusion criteria: Inclusion criteria: 1. On ART for less than 6 months 2. No evidence of viral suppression 3. Documented CD4 count \>350 copies/ul 4. TB-suggestive x-ray 5. Verified absence of fever and cough, as ascertained through the symptom trackers Contacts: Inclusion criteria: All close contacts (household and close community contacts) will be offered to participate in the study, regardless of age or HIV status. Exclusion criteria: 1. Plans to migrate in the next 12 months 2. Pregnant women 3. Currently taking anti-tuberculosis treatment or preventive TB treatment 4. Contacts with co-prevalent TB identified at baseline

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Conditions

The condition(s) this trial relates to.

active tuberculosis AIDS HIV infectious disease latent tuberculosis infection tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV HIV (human immunodeficiency virus) Tuberculosis Tuberculosis (TB)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centro de Investigação em Saúde de Manhiça (CISM)

    RECRUITING

    Manhiça, Maputo Province, Mozambique

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