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Could a common diabetes drug help obese nigerians lose weight?

NCT ID NCT07297290

Disease control Sponsor: University Of Nigeria Teaching Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether metformin, a drug already used for diabetes, can help obese but non-diabetic Black Nigerians lose weight and lower their heart disease risk. Researchers will give 220 participants either metformin or a placebo for several months, tracking changes in weight, waist size, and insulin resistance. The goal is to find an affordable, accessible weight-loss option for a population with limited access to expensive treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Metformin
What this could lead to
If it works, this could provide an affordable, accessible weight-loss option for obese individuals in Nigeria and similar populations.
What could go wrong
This is a single-site trial in a specific population, so results may not apply broadly. Metformin's weight-loss effects are modest, and side effects like gastrointestinal issues are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 220 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 59 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Obesity (defined as body mass index ≥ 30kg/m2), * Fasting plasma glucose (\<7.0mmol/L) * No medical treatment for weight control in the previous 12 months * No participation in a current clinical trial Exclusion Criteria: * • Obesity (defined as body mass index ≥ 30kg/m2), * Fasting plasma glucose (\<7.0mmol/L) * No medical treatment for weight control in the previous 12 months * No participation in a current clinical trial

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Conditions

The condition(s) this trial relates to.

Insulin Resistance Obesity obesity disorder Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Insulin resistance Obesity (body mass index &GT;30 KG/M2) Obesity and cardiovascular risk

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Pathology Facility

    RECRUITING

    Enugu, Enugu State, Nigeria

  • University of Nigeria Teaching Hospital

    RECRUITING

    Enugu, Enugu State, Nigeria

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