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Could a pill save insulin cells? new trial for kids and young adults with type 1 diabetes

NCT ID NCT07222332

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 8 times

Summary

This study tests whether baricitinib, a pill, can help preserve the body's ability to make insulin in people newly diagnosed with type 1 diabetes. About 300 children and young adults (ages 1 to under 36) will take either baricitinib or a placebo for 60 weeks. The goal is to see if the drug slows the loss of beta cells, which produce insulin, potentially reducing the need for insulin shots over time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 year to 35 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a new diagnosis of type 1 diabetes within 100 days prior to starting study intervention * Have at least one diabetes-related autoantibody found at screening * Show signs of remaining beta-cell function * stimulated (peak or 90 min) C-peptide ≥0.2 nmol/L (0.6 ng/mL) at screening * Weigh at least 8 kilograms (kg) (18 pounds) at screening Exclusion Criteria: * Have any other type of diabetes including gestational * Have uncontrolled high blood pressure * Have had a heart attack, heart disease, stroke, or heart failure * Have a history or high risk of venous thromboembolism, lymphoproliferative disease or malignancy * Have a current or recent clinically serious medical condition or infection

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

type 1 diabetes mellitus type 1 diabetes mellitus 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus, type 1

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    137 sites in 20 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • 2Ca Braga

    RECRUITING

    Braga, 4710-243, Portugal

  • Abeno Medical Clinic

    NOT_YET_RECRUITING

    Osaka, 545-0052, Japan

  • Aberdeen Royal Infirmary

    RECRUITING

    Aberdeen, AB25 2ZN, United Kingdom

  • Addenbrooke's Hospital

    RECRUITING

    Cambridge, CB2 2QQ, United Kingdom

  • Akershus Universitetssykehus

    RECRUITING

    Lørenskog, 1478, Norway

  • Alberta Children's Hospital

    NOT_YET_RECRUITING

    Calgary, T3B 6A8, Canada

  • Alberta Diabetes Institute

    NOT_YET_RECRUITING

    Edmonton, T6G 2E1, Canada

  • Antwerp University Hospital

    NOT_YET_RECRUITING

    Edegem, 2650, Belgium

  • Asklepios Klinik Sankt Augustin

    RECRUITING

    Sankt Augustin, 53757, Germany

  • Assistance Publique - Hopitaux de Paris (AP-HP) - Hopital Robert Debre - Centre Hospitalo Universitaire (C -T

    NOT_YET_RECRUITING

    Paris, 75019, France

  • Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone

    NOT_YET_RECRUITING

    Marseille, 13385, France

  • Austin Health - Repatriation Hospital

    RECRUITING

    Heidelberg West, 3081, Australia

  • Azienda Ospedale - Università Padova

    NOT_YET_RECRUITING

    Padova, 35128, Italy

  • Azienda Ospedale - Università Padova

    NOT_YET_RECRUITING

    Padova, 35128, Italy

  • Azienda Ospedaliera Universitaria Careggi

    RECRUITING

    Florence, 50134, Italy

  • Azienda Ospedaliera Universitaria Di Messina G. Martino

    RECRUITING

    Messina, 98125, Italy

  • Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento

    RECRUITING

    Verona, 37126, Italy

  • Azienda Ospedaliera Universitaria Meyer IRCCS

    RECRUITING

    Florence, 50139, Italy

  • Azienda Ospedaliero Universitaria Maggiore della Carità

    RECRUITING

    Novara, 28100, Italy

  • BC Diabetes Office

    RECRUITING

    Vancouver, V5Y 3W2, Canada

  • Barbara Davis Center for Childhood Diabetes

    RECRUITING

    Aurora, Colorado, 80045, United States

  • Birmingham Children's Hospital

    RECRUITING

    Birmingham, B4 6NH, United Kingdom

  • CEDOES

    RECRUITING

    Vitória, 29055450, Brazil

  • CHU Rangueil

    NOT_YET_RECRUITING

    Toulouse, 31059, France

  • CHU UCL Namur/Site Sainte Elisabeth

    NOT_YET_RECRUITING

    Namur, 5000, Belgium

  • CHUL et Centre mère-enfant Soleil

    NOT_YET_RECRUITING

    Québec, G1V 4G2, Canada

  • CIUSSS- saguenay-Lac-Saint-Jean

    RECRUITING

    Chicoutimi, G7H 5H6, Canada

  • CPCLIN

    RECRUITING

    São Paulo, 01228-200, Brazil

  • Cendi - Endocrinologia e Diabetes

    RECRUITING

    Goiânia, 74230-035, Brazil

  • Centre Hospitalier Sud Francilien

    NOT_YET_RECRUITING

    Corbeil-Essonnes, 91106, France

  • Centre Hospitalier Universitaire de Grenoble

    NOT_YET_RECRUITING

    Grenoble, 38700, France

  • Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman

    RECRUITING

    Liège, 4000, Belgium

  • Centre for Children's Health Research

    NOT_YET_RECRUITING

    Brisbane, 4101, Australia

  • Centricity Research Ottawa LMC Endocrinology

    RECRUITING

    Ottawa, K2J 0V2, Canada

  • Centro De Diabetes Metabolismo E Endocrinologia

    RECRUITING

    Fortaleza, 60175-047, Brazil

  • Centro Materno Infantil do Norte

    RECRUITING

    Porto, 4050, Portugal

  • Centro de Diabetes Curitiba

    RECRUITING

    Curitiba, 80810-040, Brazil

  • Centro de Pesquisa Clínica de Marília - CPCLIM

    RECRUITING

    Marília, 17504-072, Brazil

  • Children's Hospital of Philadelphia (CHOP)

    NOT_YET_RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Churchill Hospital

    RECRUITING

    Oxford, OX3 7LE, United Kingdom

  • Cliniques universitaires Saint-Luc

    NOT_YET_RECRUITING

    Brussels, 1200, Belgium

  • Clínica Hepatogastro JK

    RECRUITING

    São Paulo, 04077-020, Brazil

  • Diabeter - Rotterdam

    RECRUITING

    Rotterdam, 3011 TA, Netherlands

  • Diabetologikum Ludwigshafen/Die Praxis am Ludwigsplatz

    RECRUITING

    Ludwigshafen am Rhein, 67059, Germany

  • Driscoll Children's Hospital

    RECRUITING

    Corpus Christi, Texas, 78411, United States

  • Fakultni nemocnice Ostrava

    RECRUITING

    Ostrava, 70852, Czechia

  • Hadassah Medical Center

    RECRUITING

    Jerusalem, 9112001, Israel

  • Hannoversche Kinderheilanstalt

    NOT_YET_RECRUITING

    Hanover, 30173, Germany

  • Helse Fonna - Haugesund Sjukehus

    RECRUITING

    Haugesund, 5528, Norway

  • Hopital Claude Huriez - CHU de Lille

    NOT_YET_RECRUITING

    Lille, 59037, France

  • Hospices Civils de Lyon - Hopital Louis Pradel

    RECRUITING

    Bron, 69677, France

  • Hospital Clínic de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Sant Joan de Déu

    RECRUITING

    Esplugues de Llobregat, 08950, Spain

  • Hospital Universitari i Politecnic La Fe

    RECRUITING

    Valencia, 46026, Spain

  • Hospital Universitario Marqués de Valdecilla

    RECRUITING

    Santander, 39008, Spain

  • Hospital Universitario Ramón y Cajal

    RECRUITING

    Madrid, 28034, Spain

  • Hospital Universitario Virgen Del Rocio

    RECRUITING

    Seville, 41013, Spain

  • Hospital Universitario Virgen Del Rocio

    RECRUITING

    Seville, 41013, Spain

  • Hospital Universitário Maria Aparecida Pedrossian

    RECRUITING

    Campo Grande, 79080-190, Brazil

  • Hospital das Clinicas FMUSP

    RECRUITING

    São Paulo, 05403-000, Brazil

  • Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP) - HCFM -T

    RECRUITING

    Ribeirão Preto, 14051-140, Brazil

  • Hospital de la Santa Creu i Sant Pau

    RECRUITING

    Barcelona, 08041, Spain

  • Hôpital Universitaire Necker Enfants Malades

    NOT_YET_RECRUITING

    Paris, 75015, France

  • IBTED - Tecnologia e Educação em Diabetes

    RECRUITING

    São Paulo, 04038-032, Brazil

  • Institute of Diabetes, Technology and Research - Clalit Health

    RECRUITING

    Herzliya, 4600201, Israel

  • Institute of Endocrinology and Metabolism named after Komissarenko

    RECRUITING

    Kiev, 04114, Ukraine

  • Instituto da Crianca com Diabetes

    RECRUITING

    Porto Alegre, 91350-250, Brazil

  • Instituto de Pesquisa Clinica

    RECRUITING

    São Paulo, 01223-001, Brazil

  • Ipswich Hospital

    RECRUITING

    Ipswich, 4305, Australia

  • Iuhw Ichikawa General Hospital

    NOT_YET_RECRUITING

    Ichikawa, 272-0824, Japan

  • Klinikum Karlsburg

    NOT_YET_RECRUITING

    Karlsburg, 17495, Germany

  • Kyiv City Endocrinological Center

    RECRUITING

    Kyiv, 01024, Ukraine

  • Linn Medical Center

    RECRUITING

    Haifa, 3515209, Israel

  • MTZ Clinical Research Powered by Pratia

    RECRUITING

    Warsaw, 02-172, Poland

  • Meir Medical Center

    RECRUITING

    Kfar Saba, 4428164, Israel

  • Milan Kvapil s.r.o., Diabetologicka ambulance

    RECRUITING

    Prague, 14900, Czechia

  • Nemocnice Jihlava

    RECRUITING

    Jihlava, 58633, Czechia

  • OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces

    RECRUITING

    Barakaldo, 48903, Spain

  • Oslo Universitetssykehus Aker

    RECRUITING

    Oslo, 0316, Norway

  • Oslo Universitetssykehus Ullevål

    RECRUITING

    Oslo, 0450, Norway

  • Ospedale Pediatrico Salesi

    NOT_YET_RECRUITING

    Ancona, 60123, Italy

  • Ospedale San Raffaele

    NOT_YET_RECRUITING

    Milan, 20132, Italy

  • Oulun yliopistollinen sairaala

    RECRUITING

    Oulu, 90220, Finland

  • Perth Children's Hospital

    RECRUITING

    Perth, 6009, Australia

  • Pitie Salpetriere University Hospital

    NOT_YET_RECRUITING

    Paris, 75013, France

  • ProbarE i Lund AB

    RECRUITING

    Lund, 222 22, Sweden

  • ProbarE i Stockholm AB

    RECRUITING

    Stockholm, 11437, Sweden

  • Quanta Diagnóstico e Terapia

    RECRUITING

    Curitiba, 80045170, Brazil

  • Queen Elizabeth Hospital Birmingham

    RECRUITING

    Birmingham, B15 2TH, United Kingdom

  • RED-Institut GmbH

    RECRUITING

    Oldenburg, 23758, Germany

  • Rabin Medical Center

    RECRUITING

    Petah Tikva, 4941492, Israel

  • Rambam Health Care Campus

    RECRUITING

    Haifa, 3109601, Israel

  • Royal Children's Hospital

    NOT_YET_RECRUITING

    Melbourne, 3052, Australia

  • Saitama Medical University Hospital

    NOT_YET_RECRUITING

    Iruma, 350-0495, Japan

  • Schneider Children's Medical Center

    RECRUITING

    Petah Tikva, 4920235, Israel

  • Schwerpunktpraxis für Diabetes Hormone & Stoffwechsel

    RECRUITING

    Hof, 95030, Germany

  • Sendai City Hospital - Asutonagamachi

    NOT_YET_RECRUITING

    Sendai, 982-8502, Japan

  • Sheba Medical Center

    RECRUITING

    Ramat Gan, 5262100, Israel

  • Shiga General Hospital

    NOT_YET_RECRUITING

    Moriyama, 524-8524, Japan

  • Shizuoka Children's Hospital

    NOT_YET_RECRUITING

    Shizuoka, 420-8660, Japan

  • Soroka Medical Center

    RECRUITING

    Beersheba, 8410101, Israel

  • Sourasky Medical Center

    RECRUITING

    Tel Aviv, 6423906, Israel

  • Southampton General Hospital

    RECRUITING

    Southampton, SO16 6YD, United Kingdom

  • Southern Adelaide Diabetes & Endocrine Services

    RECRUITING

    Oaklands Park, 5046, Australia

  • Southmead Hospital

    RECRUITING

    Bristol, BS10 5NB, United Kingdom

  • St. Joseph's Health Care

    NOT_YET_RECRUITING

    London, N6A 4V2, Canada

  • St. Olavs Hospital

    RECRUITING

    Trondheim, 7030, Norway

  • Stavanger Universitetssykehus

    RECRUITING

    Stavanger, 4011, Norway

  • Sydney Children's Hospital

    RECRUITING

    Randwick, 2031, Australia

  • TUM Klinikum

    RECRUITING

    München, 80939, Germany

  • Tallahassee Memorial HealthCare

    RECRUITING

    Tallahassee, Florida, 32308, United States

  • Tampereen yliopistollinen sairaala

    RECRUITING

    Tampere, 33520, Finland

  • The Children's Hospital at Westmead

    RECRUITING

    Westmead, 2145, Australia

  • The Royal Melbourne Hospital

    RECRUITING

    Parkville, 3050, Australia

  • Turku University Hospital

    RECRUITING

    Turku, 20520, Finland

  • ULSAM - Hospital de Santa Luzia

    RECRUITING

    Viana do Castelo, 4900-858, Portugal

  • UMED Clinical Trials

    RECRUITING

    Lodz, 92-213, Poland

  • UZ Brussel

    RECRUITING

    Brussels, 1090, Belgium

  • UZ Gent

    RECRUITING

    Ghent, 9000, Belgium

  • UZ Leuven

    RECRUITING

    Leuven, 3000, Belgium

  • Uddevalla Sjukhus

    RECRUITING

    Uddevalla, 451 53, Sweden

  • Unidade Local De Saude De Gaia/Espinho E.P.E.

    NOT_YET_RECRUITING

    Vila Nova de Gaia, 4434-502, Portugal

  • Universidade Federal do Rio de Janeiro

    RECRUITING

    Rio de Janeiro, 21941-590, Brazil

  • Universitaetsklinikum Ulm

    RECRUITING

    Ulm, 89075, Germany

  • Universitetssjukhuset Örebro

    RECRUITING

    Örebro, 701 85, Sweden

  • University Hospital of Wales

    RECRUITING

    Cardiff, CF14 4XW, United Kingdom

  • University of Naples Federico II

    RECRUITING

    Naples, 80131, Italy

  • University of Virginia

    RECRUITING

    Charlottesville, Virginia, 22903, United States

  • Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne

    NOT_YET_RECRUITING

    Yvoir, 5530, Belgium

  • Université Libre de Bruxelles - Hôpital Erasme

    NOT_YET_RECRUITING

    Brussels, 1070, Belgium

  • Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu

    RECRUITING

    Wroclaw, 50-368, Poland

  • Uniwersyteckie Centrum Kliniczne

    RECRUITING

    Gdansk, 80-952, Poland

  • Vinnytsia Regional Clinical Endocrinology Dispensary

    RECRUITING

    Vinnytsia, 21010, Ukraine

  • Women's and Children's Hospital

    RECRUITING

    Adelaide, 5006, Australia

  • Yitzhak Shamir Medical Center

    RECRUITING

    Beer Yaacov, 70300, Israel

  • Zakarpattia Endoclinic

    RECRUITING

    Uzhhorod, 88000, Ukraine

  • Östersunds Sjukhus

    NOT_YET_RECRUITING

    Östersund, 831 31, Sweden

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