New weekly shot could boost weight loss for those still struggling on current meds

NCT ID NCT07392190

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Sep 09, 2026 · Updated 8 times

Summary

This study tests a new weekly injection called eloralintide in 900 adults with obesity or overweight who are already taking a weekly incretin drug (like Ozempic or Wegovy) but still have excess weight. Participants will receive either eloralintide or a placebo for about 80 weeks to see if it helps them lose more weight and improve health measures like waist size and blood pressure. The goal is to find a safe add-on treatment for people who need extra help managing their weight.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 900 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Are on stable incretin therapy at screening * With persistent obesity or overweight defined as: * ≥30 kg/m2 OR * ≥27 kg/m2 with at least one existing obesity related complication at screening: * hypertension * dyslipidemia * obstructive sleep apnea * cardiovascular disease (for example, ischemic cardiovascular disease, New York Heart Association Functional Class I-III heart failure), or * type 2 diabetes * Have a stable body weight (\<5% body weight change) at screening Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes * Have taken any of the following antihyperglycemic medications within 90 days before screening: * dipeptidyl peptidase-4 (DPP-4) inhibitors * amylin analogs * insulin * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure

Get updates

Get notified about this study

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Overweight

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

187 sites in 14 countries. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

2nd Affiliated Hospital Chongqing Medical Universi
NOT_YET_RECRUITING

Chongqing, 400000, China
AIM Research
RECRUITING

Merewether, 2291, Australia
AMR Clinical
RECRUITING

Doral, Florida, 33172, United States
AMR Clinical
RECRUITING

Lexington, Kentucky, 40509, United States
AZ Groeninge Campus Kennedylaan
RECRUITING

Kortrijk, 8500, Belgium
AZ Sint-Maarten
RECRUITING

Mechelen, 2800, Belgium
Accellacare - Wilmington - 1917 Tradd Court
RECRUITING

Wilmington, North Carolina, 28401, United States
Activian Clinical Research
RECRUITING

Kingwood, Texas, 77339, United States
Advanced Clinical Research, LLC
RECRUITING

Bayamón, 00959, Puerto Rico
Affiliated Hospital of Luzhou Medical College
NOT_YET_RECRUITING

Luzhou, 646000, China
All India Institute of Medical Sciences (AIIMS) - Nagpur
SUSPENDED

Nagpur, 441108, India
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
RECRUITING

Troy, Michigan, 48098, United States
Artemis Institute for Clinical Research
RECRUITING

San Diego, California, 92123, United States
Atmaram Child Care
SUSPENDED

Kanpur, 208011, India
Austin Health - Repatriation Hospital
RECRUITING

Heidelberg West, 3081, Australia
Az Damiaan vzw
RECRUITING

Ostend, 8400, Belgium
BSES MG Hospital
SUSPENDED

Mumbai, 400058, India
Barwon Health
RECRUITING

Geelong, 3220, Australia
Birmingham Clinical Research
RECRUITING

Birmingham, Alabama, 35209, United States
Box Hill Hospital
RECRUITING

Box Hill, 3128, Australia
Brigham and Women's Hospital Diabetes Program
RECRUITING

Boston, Massachusetts, 02115, United States
C.M.D.T.A. Neomed
RECRUITING

Brasov, 500283, Romania
CEDOES
NOT_YET_RECRUITING

Vitória, 29055450, Brazil
CEINV Salud
NOT_YET_RECRUITING

Monterrey, 64020, Mexico
CPCLIN
NOT_YET_RECRUITING

São Paulo, 01228-200, Brazil
CTI Clinical Research Center
RECRUITING

Cincinnati, Ohio, 45212, United States
Cabinet Medical Dr.Geru
RECRUITING

Timișoara, 300288, Romania
Care Access - Lima
RECRUITING

Lima, Ohio, 45805, United States
Care Access - Sacramento
NOT_YET_RECRUITING

Sacramento, California, 95831, United States
Carteret Medical Group
RECRUITING

Morehead City, North Carolina, 28557, United States
Centennial Medical Group
RECRUITING

Columbia, Maryland, 21045, United States
Center for Advanced Research & Education
RECRUITING

Gainesville, Georgia, 30501, United States
Centro Periférico de Especialidades Bola Azul
RECRUITING

Almería, 04009, Spain
Centro de Diabetes Curitiba
NOT_YET_RECRUITING

Curitiba, 80810-040, Brazil
Centro de Investigacion en Artritis y Osteoporosis SC
NOT_YET_RECRUITING

Mexicali, 21200, Mexico
Centrul Medical NutriLife
RECRUITING

Bucharest, 013764, Romania
Chang Gung Medical Foundation-Linkou Branch
RECRUITING

Taoyuan, 333, Taiwan
Chang Gung Memorial Hospital at Kaohsiung
RECRUITING

Kaohsiung Niao Sung Dist, 83301, Taiwan
Chase Medical Research, LLC
RECRUITING

Waterbury, Connecticut, 06708, United States
Chiayi Christian Hospital
RECRUITING

Chiayi City, 600, Taiwan
China Medical University Hospital
RECRUITING

Taichung, 404332, Taiwan
Clalit Health Services - Atlit
NOT_YET_RECRUITING

Atlit, 3032301, Israel
Clalit Health Services - Sakhnin Community Clinic
NOT_YET_RECRUITING

Sakhnin, 3081000, Israel
Clinica Korall
RECRUITING

Satu Mare, 440055, Romania
Clinical Research Atlanta
RECRUITING

Stockbridge, Georgia, 30281, United States
Clinical Research Professionals
RECRUITING

Chesterfield, Missouri, 63005, United States
Clínica García Flores SC
NOT_YET_RECRUITING

Monterrey, 64610, Mexico
Clínica Juaneda
RECRUITING

Palma de Mallorca, 07014, Spain
Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
RECRUITING

Seville, 41003, Spain
Consano Clinical Research, LLC
RECRUITING

Shavano Park, Texas, 78231, United States
Cotton O'Neil Diabetes & Endocrinology
RECRUITING

Topeka, Kansas, 66606, United States
Diabdana
RECRUITING

Oradea, 410147, Romania
Diabetes Medical Center
NOT_YET_RECRUITING

Tel Aviv, 51549, Israel
Diahaza s.r.o.
RECRUITING

Holešov, 769 01, Czechia
Edith Wolfson Medical Center
NOT_YET_RECRUITING

Holon, 5810001, Israel
Emek Medical Center
NOT_YET_RECRUITING

Afula, 1834111, Israel
Emeritus Research
RECRUITING

Botany, 2019, Australia
Emeritus Research
RECRUITING

Camberwell, 3124, Australia
Endeavor Clinical Trials
RECRUITING

San Antonio, Texas, 78240, United States
EndoTrials Center for Clinical Research
NOT_YET_RECRUITING

La Mesa, California, 91942, United States
Eternal Heart Care Center and Research Institute
SUSPENDED

Jaipur, 302020, India
Family First Medical Center
RECRUITING

Idaho Falls, Idaho, 83404, United States
Gama Diamed
RECRUITING

Mangalia, 905500, Romania
Gastrobariátrica Santa Fe
NOT_YET_RECRUITING

Mexico City, 05348, Mexico
Geea Medical Easy Diet
RECRUITING

Bucharest, 010627, Romania
Great Lakes Clinical Trials - Ravenswood
RECRUITING

Chicago, Illinois, 60640, United States
Great Lakes Research Institute
RECRUITING

Southfield, Michigan, 48075, United States
Hadassah Medical Center
NOT_YET_RECRUITING

Jerusalem, 9112001, Israel
Headlands Research - Scottsdale
RECRUITING

Scottsdale, Arizona, 85260, United States
Hillel Yaffe Medical Center
NOT_YET_RECRUITING

Hadera, 3810101, Israel
Hospital 9 De Julho
NOT_YET_RECRUITING

São Paulo, 01409-901, Brazil
Hospital Quiron Infanta Luisa
RECRUITING

Seville, 41010, Spain
Hospital San Rafael - La Coruña
RECRUITING

A Coruña, 15006, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario Marqués de Valdecilla
RECRUITING

Santander, 39008, Spain
Hospital Universitario Quironsalud Madrid
RECRUITING

Pozuelo de Alarcón, 28223, Spain
Huzhou Central Hospital
NOT_YET_RECRUITING

Huzhou, 313000, China
IMA Clinical Research Manhattan
RECRUITING

New York, New York, 10036, United States
IMA Clinical Research Monroe - Armand
RECRUITING

Monroe, Louisiana, 71201, United States
IMA Clinical Research San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Imelda General Hospital
RECRUITING

Bonheiden, 2820, Belgium
Innovate Clinical Research
RECRUITING

Waitara, 2077, Australia
Instituto Gallego de Cirugía Ocular
RECRUITING

Ferrol, 15402, Spain
Integral Pesquisa e Ensino
NOT_YET_RECRUITING

Votuporanga, 15500-269, Brazil
Invecordis S.C.
NOT_YET_RECRUITING

Huixquilucan, 52763, Mexico
Iowa Diabetes and Endocrinology Research Center
RECRUITING

West Des Moines, Iowa, 50266, United States
Irvine Clinical Research
RECRUITING

Irvine, California, 92614, United States
Isis Clinical Research Center
RECRUITING

Guaynabo, 00968, Puerto Rico
JEM Research Institute
RECRUITING

Atlantis, Florida, 33462, United States
Jacksonville Center for Clinical Research
RECRUITING

Jacksonville, Florida, 32216, United States
Jan Yperman Ziekenhuis
RECRUITING

Ieper, 8900, Belgium
Japanese Red Cross Society - Wakayama Medical Center
RECRUITING

Wakayama, 640-8558, Japan
Jiangxi Provincial People's Hospital
NOT_YET_RECRUITING

Nanchang, 330038, China
Jinan Central Hospital
NOT_YET_RECRUITING

Jinan, 250013, China
Juno Research
RECRUITING

Houston, Texas, 77040, United States
Kansai Electric Power Hospital
RECRUITING

Osaka, 553-0003, Japan
Kanto Rosai Hospital
RECRUITING

Kawasaki, 211-8510, Japan
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Kaplan Medical Center
NOT_YET_RECRUITING

Rehovot, 7610001, Israel
Kimitsu Chuo Hospital
RECRUITING

Kisarazu, 292-8535, Japan
Kure Medical Center
RECRUITING

Kure, 737-0023, Japan
Laniado Hospital
NOT_YET_RECRUITING

Netanya, 4244914, Israel
Life Care Hospital and Research Centre
SUSPENDED

Bangalore, 560092, India
Maccabi health care services - Qiryat Motzkin
NOT_YET_RECRUITING

Kiryat Motzkin, 2642435, Israel
Madras Diabetes Research Foundation
SUSPENDED

Chennai, 600086, India
Manda Memorial Hospital
RECRUITING

Sapporo, 060-0062, Japan
Mariodiab Clinic
RECRUITING

Brasov, 500097, Romania
Meclinas
RECRUITING

Mechelen, 2800, Belgium
MedVadis Research Corporation
RECRUITING

Waltham, Massachusetts, 02451, United States
Medication Management
RECRUITING

Greensboro, North Carolina, 27405, United States
Medrasa Clinical Research
RECRUITING

Wylie, Texas, 75098, United States
Meir Medical Center
NOT_YET_RECRUITING

Kfar Saba, 4428164, Israel
Metabolic Research Institute, Inc.
RECRUITING

West Palm Beach, Florida, 33401, United States
Mikannohana Clinic, Diabetes, Endocrinology and Metabolism
RECRUITING

Matsuyama, 7900034, Japan
Milan Kvapil s.r.o., Diabetologicka ambulance
RECRUITING

Prague, 14900, Czechia
Motilal Nehru Medical College Hospital
SUSPENDED

Allahābād, 211002, India
Mysore Medical College
SUSPENDED

Mysore, 570001, India
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Nanjing First Hospital
NOT_YET_RECRUITING

Nanjing, 210006, China
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
New England Research Associates, LLC
RECRUITING

Bridgeport, Connecticut, 06606, United States
New Horizon Research Center
RECRUITING

Miami, Florida, 33165, United States
Ningbo First Hospital
NOT_YET_RECRUITING

Ningbo, 315010, China
Nirmal Hospital Pvt Ltd.
SUSPENDED

Surat, 395002, India
Nizam's Institute of Medical Sciences
SUSPENDED

Hyderabad, 500082, India
Northeast Research Institute (NERI)
RECRUITING

Fleming Island, Florida, 32003, United States
Novak Clinical Research - Tucson - North La Cholla Boulevard
RECRUITING

Tucson, Arizona, 85741, United States
Peninsula Research Associates
RECRUITING

Rolling Hills Estates, California, 90274, United States
Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)
RECRUITING

Pittsburgh, Pennsylvania, 15236, United States
Private Practice - Dr. Arechavaleta Granell Maria del Rosario
NOT_YET_RECRUITING

Guadalajara, 44670, Mexico
Private Practice - Dr.Miguel N. Hissa
NOT_YET_RECRUITING

Fortaleza, 60430-350, Brazil
Quanta Diagnóstico e Terapia
NOT_YET_RECRUITING

Curitiba, 80045170, Brazil
RIO Clinical Trials - Phoenix
RECRUITING

Phoenix, Arizona, 85016, United States
Rabin Medical Center
NOT_YET_RECRUITING

Petah Tikva, 4941492, Israel
Rabin Medical Center - Hasharon Campus
NOT_YET_RECRUITING

Petah Tikva, 4937211, Israel
Rambam Health Care Campus
NOT_YET_RECRUITING

Haifa, 3109601, Israel
ResTrial s.r.o.
RECRUITING

Prague, 18100, Czechia
Revive Research Institute, Inc.
RECRUITING

Southfield, Michigan, 48075, United States
Rinart Diab SRL
RECRUITING

Targoviste, 130168, Romania
Rinku General Medical Center
RECRUITING

Izumisano, 598-8577, Japan
Royal Brisbane and Women's Hospital
RECRUITING

Brisbane, 4029, Australia
Royal North Shore Hospital
RECRUITING

St Leonards, 2065, Australia
SC Dentosim Queen SRL - Centrul Medical Diamed
RECRUITING

Târgu Mureş, 540098, Romania
Scripps Whittier Diabetes Institute
RECRUITING

La Jolla, California, 92037, United States
Sheba Medical Center
NOT_YET_RECRUITING

Ramat Gan, 5262100, Israel
Shimonoseki Medical Center
RECRUITING

Shimonoseki, 750-0061, Japan
Shree Mahalaxmi DIATONE Institute
SUSPENDED

Kolhāpur, 416001, India
Sichuan Provincial People's Hospital
NOT_YET_RECRUITING

Chengdu, 610072, China
Soroka Medical Center
NOT_YET_RECRUITING

Beersheba, 8410101, Israel
Sourasky Medical Center
NOT_YET_RECRUITING

Tel Aviv, 6423906, Israel
Southern Adelaide Diabetes & Endocrine Services
RECRUITING

Oaklands Park, 5046, Australia
Southern California Clinical Research
RECRUITING

Santa Ana, California, 92701, United States
St Johns Center for Clinical Research
RECRUITING

Saint Augustine, Florida, 32086, United States
Supe Heart & Diabetes Hospital and Research Centre
SUSPENDED

Nashik, 422002, India
Synergy Groups Medical LLC - Missouri City
RECRUITING

Missouri City, Texas, 77459, United States
Taipei Medical University Hospital
RECRUITING

Taipei, 110, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Takeda General Hospital - Kyoto
RECRUITING

Kyoto, 601-1495, Japan
Teak Research Consults - Dunwoody
RECRUITING

Dunwoody, Georgia, 30338, United States
Texas Valley Clinical Research
RECRUITING

Weslaco, Texas, 78596, United States
Texas Valley Clinical Research (TVCR) - Mission
RECRUITING

Mission, Texas, 78572, United States
The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
NOT_YET_RECRUITING

Wenzhou, 315100, China
The Affiliated Hospital of Guizhou Medical University
NOT_YET_RECRUITING

Guiyang, 550004, China
The Central Hospital of Wuhan
NOT_YET_RECRUITING

Wuhan, 430014, China
The First Affiliated Hospital of Henan University of Science &Technology
NOT_YET_RECRUITING

Luoyang Shi, 471023, China
The First Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, 130021, China
The Institute of Medical Science, Asahi Life Foundation
RECRUITING

Chūōku, 103-0002, Japan
The Second Affiliated Hospital of Nanjing Medical University
NOT_YET_RECRUITING

Nanjing, 210011, China
The Second Hospital of Jilin University
NOT_YET_RECRUITING

Changchun, 130041, China
The Second People's Hospital of Hefei
NOT_YET_RECRUITING

Hefei, 230011, China
The Second Xiangya Hospital of Central South University
NOT_YET_RECRUITING

Changsha, 410011, China
Trial Management Associates
NOT_YET_RECRUITING

Myrtle Beach, South Carolina, 29572, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
University Clinical Investigators, Inc.
RECRUITING

Tustin, California, 92780, United States
University of North Carolina Medical Center
RECRUITING

Chapel Hill, North Carolina, 27514, United States
Université Libre de Bruxelles - Hôpital Erasme
RECRUITING

Brussels, 1070, Belgium
Vithas Hospital Sevilla
RECRUITING

Seville, 41950, Spain
Weill Cornell Medical College
RECRUITING

New York, New York, 10021, United States
West China Hospital Sichuan University
NOT_YET_RECRUITING

Chengdu, 610041, China
Xianyang Hospital of Yan'an University
NOT_YET_RECRUITING

Xianyang, 712000, China
Yale University School of Medicine
RECRUITING

New Haven, Connecticut, 06519, United States
Zhongda Hospital Southeast University
NOT_YET_RECRUITING

Nanjing, 210009, China
Zhongshan Hospital,Fudan University
NOT_YET_RECRUITING

Shanghai, 200032, China
Zhujiang Hospital
NOT_YET_RECRUITING

Guangzhou, 510280, China
Ziekenhuis Oost-Limburg, Campus St.-Jan
RECRUITING

Genk, 3600, Belgium

More trials for these conditions

Other studies related to the condition(s) this trial covers.