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New drug combo aims to shed pounds and control diabetes

NCT ID NCT07215559

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Sep 09, 2026 · Updated 8 times

Summary

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will receive the drugs or a placebo for 48 weeks. The main goal is to see how much weight they lose and how their blood sugar changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
macupatide and eloralintide (drugs)
What this could lead to
If successful, this could lead to a new treatment option for weight loss in people with obesity and type 2 diabetes, potentially improving blood sugar control.
What could go wrong
This is an early phase 2 trial with only 200 participants, so results may not apply to everyone. The drugs may cause side effects or fail to show significant weight loss compared to placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have type 2 diabetes * Have an HbA1c ≥7.5% to ≤10.5% at screening * Have been treated with any of the following, alone or in combination, for at least 3 months prior to screening * Diet and exercise * Stable dose of metformin * Sodium-glucose cotransporter-2 (SGLT2) inhibitor * Have had a stable body weight (\<5% body weight gain and/or loss) for the 3 months prior to screening * Have a BMI of 27 or greater at screening Exclusion Criteria: * Have any form of diabetes other than type 2 diabetes * Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening * Have any of the following cardiovascular conditions within 3 months prior to screening: * acute myocardial infarction * cerebrovascular accident (stroke) * unstable angina, or * hospitalization due to congestive heart failure * Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years, exceptions include * basal or squamous cell skin cancer * in situ carcinomas of the cervix, or * in situ prostate cancer * Have been prescribed any of the following receptor agonists (RA) or their combination for any indication within the last 6 months: * amylin RA * dual amylin and calcitonin RA * glucagon-like peptide-1 receptor (GLP-1) RA * glucose-dependent insulinotropic peptide (GIP)/GLP-1 RA * GLP-1/glucagon (GCG) RAs, or * GIP/GLP-1/GCG RAs * Have used excluded antihyperglycemic medications within 3 months prior to screening (including, but not limited to, sulfonylureas, dipeptidyl peptidase-4 inhibitors, alpha-glucosidase inhibitors, thiazolidinediones, and meglitinides * Have used insulin for diabetic control within the prior year (short term use in certain situations allowed

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus type 2 Obesity Overweight

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    41 sites in 4 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AGILE Clinical Research Trials, LLC

    RECRUITING

    Sandy Springs, Georgia, 30328, United States

  • AIM Research

    COMPLETED

    Merewether, 2291, Australia

  • Aavon Clinical Trials

    RECRUITING

    Richmond, Texas, 77407, United States

  • Biopharma Informatic, LLC

    RECRUITING

    Houston, Texas, 77043, United States

  • CDH Research Institute Pty Ltd

    RECRUITING

    Maroochydore, 4558, Australia

  • CEDIC

    RECRUITING

    CABA, C1060ABN, Argentina

  • CENUDIAB

    RECRUITING

    Buenos Aires, C1440AAD, Argentina

  • Centro de Investigaciones Metabólicas (CINME)

    RECRUITING

    Buenos Aires, C1056ABI, Argentina

  • Clinical Research Partners, LLC

    RECRUITING

    Richmond, Virginia, 23226, United States

  • Clínica Universitaria Reina Fabiola

    RECRUITING

    Córdoba, X50004FHP, Argentina

  • Consano Clinical Research, LLC

    RECRUITING

    Shavano Park, Texas, 78231, United States

  • Core Research Group

    RECRUITING

    Brisbane, 4064, Australia

  • Cornerstone Dermatology

    RECRUITING

    Coorparoo, 4151, Australia

  • Eastern Virginia Medical School (EVMS) Medical Group

    RECRUITING

    Norfolk, Virginia, 23510, United States

  • Emeritus Research

    RECRUITING

    Botany, 2019, Australia

  • Emeritus Research

    RECRUITING

    Camberwell, 3124, Australia

  • Go Centro Medico San Nicolás

    RECRUITING

    San Nicolás, 2900, Argentina

  • Instituto de Investigaciones Clínicas Córdoba

    RECRUITING

    Córdoba, 5000, Argentina

  • Kalo Clinical Research

    RECRUITING

    West Valley City, Utah, 84120, United States

  • Mercy Family Clinic

    RECRUITING

    Dallas, Texas, 75208, United States

  • Mgcendo Llc

    RECRUITING

    San Juan, 00921, Puerto Rico

  • Momentum Darlinghurst

    RECRUITING

    Darlinghurst, Sydney, 2010, Australia

  • Momentum Sunshine

    RECRUITING

    Melbourne, 3021, Australia

  • Northwest Clinical Research Center

    RECRUITING

    Bellevue, Washington, 98007, United States

  • Pima Heart

    RECRUITING

    Tucson, Arizona, 85741, United States

  • Pivotal Research Solutions

    RECRUITING

    Stonecrest, Georgia, 30038, United States

  • PlanIt Research, PLLC

    RECRUITING

    Houston, Texas, 77079, United States

  • Precision Clinical Research

    RECRUITING

    Sunrise, Florida, 33351, United States

  • Premier Research

    RECRUITING

    Trenton, New Jersey, 08611, United States

  • PriMED Clinical Research

    RECRUITING

    Dayton, Ohio, 45429, United States

  • Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC

    RECRUITING

    Gilbert, Arizona, 85296, United States

  • Rainier Clinical Research Center

    RECRUITING

    Renton, Washington, 98057, United States

  • Research Physicians Network, LLC

    RECRUITING

    Houston, Texas, 77089, United States

  • Rophe Adult and Pediatric Medicine/SKYCRNG

    RECRUITING

    Union City, Georgia, 30291, United States

  • SKY Clinical Research Network Group-Brown

    RECRUITING

    Atlanta, Georgia, 30331, United States

  • San Juan Bautista School of Medicine - Clinical Research Unit

    RECRUITING

    Caguas, 00726, Puerto Rico

  • Synexus Clinical Research US, Inc.

    RECRUITING

    Phoenix, Arizona, 85020, United States

  • Teak Research Consults

    RECRUITING

    Lawrenceville, Georgia, 30043, United States

  • Texas Valley Clinical Research

    RECRUITING

    Weslaco, Texas, 78596, United States

  • Universal Research Group

    RECRUITING

    Tacoma, Washington, 98405, United States

  • Vector Clinical Trials

    RECRUITING

    Las Vegas, Nevada, 89128, United States

  • Velocity Clinical Research, Dallas

    RECRUITING

    Dallas, Texas, 75230, United States

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