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Teen diabetes study seeks to uncover hidden triggers of kidney damage

NCT ID NCT02818192

Knowledge-focused Sponsor: University of Manitoba Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This research study follows 500 adolescents with type 2 diabetes to understand why some develop kidney problems. Researchers are looking at biological factors like blood sugar and blood pressure, as well as psychological and social factors such as stress, mental health, and poverty. The goal is to find the main causes of kidney damage in these teens and identify ways to prevent it.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could identify key risk factors and pathways for kidney disease in teens with type 2 diabetes, pointing toward better prevention strategies.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly test any new therapy. The findings may not apply to all populations or lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2017

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Prevalent youth 10-18 years of age being treated for T2D at 7 pediatric endocrinology clinics across Canada (Stollery Hospital in Edmonton, Alberta Children's Hospital in Calgary, Children's Hospital of Saskatoon, Children's Hospital of Winnipeg, Children's Hospital of Eastern Ontario in Ottawa, SickKids Hospital in Toronto, and the IWK Health Centre in Halifax)

Ages

10 to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All youth with T2D that do not meet exclusion criteria are eligible for the study. Criteria for Diagnosis of T2D: 1. Diagnosis of diabetes will be made according to the Canadian Diabetes Association criteria. There must be 2 abnormal blood glucose tests on different days OR 1 abnormal blood glucose test + symptoms of diabetes: * Fasting plasma glucose of \> 7.0 mmol/L or * Random glucose \> 11.1mmol/L or * 2 hour glucose \> 11.1 mmol/L after a standard oral glucose tolerance test (75g) or * Hemoglobin A1c value ≥ 6.5% 2. Distinguishing T2D from type 1 diabetes (T1D) will be based on clinical risk factors including: * Presence of overweight/obesity, * Other evidence of insulin resistance (acanthosis nigricans) * Family history of type 2 diabetes (1st degree relative) * Intrauterine exposure to hyperglycemia, * Family heritage from a high-risk ethnic group (Indigenous, Hispanic, South Asian, Asian or African descent) * Absence of diabetes associated auto-antibodies * HNF-1 alpha heterozygote or homozygote Exclusion Criteria: 1. Diabetes secondary to medication use or surgery 2. Antibodies suggestive of type 1 diabetes 3. Current treatment with oral steroids or immunosuppressive agents as they may interfere with cortisol assessment and inflammatory markers 4. Ever cancer 5. Other chronic illness associated with systemic inflammation (ex. Juvenile rheumatoid arthritis, Crohns disease) 6. Patient and or caregiver unable or unwilling to provide voluntary informed assent/consent

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Conditions

The condition(s) this trial relates to.

kidney disorder proteinuria type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nephropathy Proteinuria Stress Type 2 diabetes

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Children's Hospital Research Institute of Manitoba/University of Manitoba

    RECRUITING

    Winnipeg, Manitoba, R3E 3P4, Canada

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