STRESS

This study looks at whether an 8-week stress reduction program can reduce inflammation in the arteries of adults who feel stressed. Researchers will use special scans to measure changes in artery inflammation. The goal is to see if managing stress can help control atherosclerosis…

This study tests whether special air cleaners and ventilators can improve indoor air quality and help control asthma in children and adults living in low-income homes. Over one year, 80 households will receive either active or placebo devices. Researchers will measure lung functi…

This study tests whether taking magnesium and vitamin B6 alongside usual treatment can reduce symptoms of depression, anxiety, and stress in people who recently started experiencing bipolar I disorder. About 40 adults aged 18 to 50 with a first episode in the last 10 years will r…

This study aims to see if college students can effectively deliver cognitive-behavioral therapy (CBT) to high school students in rural Pennsylvania who are dealing with depression, anxiety, or stress. About 40 teens aged 13-18 will take part. The goal is to provide a low-cost, ac…

This study is testing a mobile health program to reduce stress for parents of justice-involved youth (ages 12-17) who have substance use issues. The goal is to help parents feel more mindful and confident, so their teens are more likely to engage in treatment. About 60 caregivers…

This study looks at whether a 6-week music class (including drumming and rhythm exercises) can improve mental and physical health in older adults living in residential care. About 60 participants will attend weekly one-hour sessions and complete surveys before and after. The goal…

This study tests whether using a virtual reality headset (REALICA) can lower pain and anxiety in people having common urology procedures like prostate biopsy, cystoscopy, or circumcision. About 56 adults will use the VR device during their procedure and report their anxiety and p…

This study looks at whether adding nuts to the diet can improve mental health in young adults. Researchers will measure changes in depression, anxiety, stress, memory, and thinking skills in 135 university students aged 18 to 25. Participants will eat nuts or follow their usual d…

This study tests a culturally adapted internet-based therapy for Farsi/Dari-speaking migrants and refugees aged 15-29 who have mild to moderate anxiety or depression. Participants will receive the therapy over 6-10 weeks, and researchers will measure changes in symptoms compared …

This study explores whether virtual reality nature scenes and special sound patterns (binaural beats) can reduce stress in healthy adults. About 52 participants will attend a single 30-minute session, with some using VR or listening to sounds, while others serve as a control grou…

This study tests whether a mindset management program called Organic Conceptions can reduce stress in women dealing with infertility. About 66 new patients at a fertility clinic will be split into two groups: one takes the program, the other does not. All participants fill out st…

This study tests a two-week smartphone app program designed to help people who have trouble feeling pleasure (anhedonia), along with symptoms of depression, anxiety, and stress. Participants will do three short daily exercises, such as savoring positive moments or practicing grat…

This study tests whether taking L-tyrosine, a natural amino acid, can help lower stress in adults undergoing outpatient hernia surgery. About 150 participants will receive the supplement or a placebo before their operation. The goal is to see if it reduces anxiety without affecti…

This study tests whether isometric neck exercises and posture advice can reduce cervicogenic headaches (headaches from neck problems) in 44 teens aged 13-19 who use smartphones 4+ hours daily. Researchers will measure changes in headache impact, neck disability, stress hormones, …

This study is testing whether a wearable device called WAVwatch 2.0, which plays sound frequencies, can help reduce stress and improve mental well-being. Researchers will enroll 100 adults in the US who can read English and do not have severe anxiety or skin sensitivities. Partic…

This study looks at whether a specific breathing practice called SKY breath meditation can help college students manage stress and anxiety. About 53 students will be split into two groups: one learns SKY breathing, the other does general yoga without special breathing. Over 8 wee…

This study looks at whether doing yoga during pregnancy can lower stress, improve sleep, and enhance sexual quality of life. About 70 pregnant women in their third trimester will take part, with half doing yoga and the other half continuing usual care. Researchers will measure ch…

This study tests whether a community health worker (called a promotora) can help Latinx and Native American adults who feel stressed get better access to mental health care. About 80 adults with moderate to high stress will either work with a promotora or receive usual resources.…

This study tests whether a daily mindfulness practice using Tao calligraphy and song can help adults feel less stressed, more connected to others, and more at peace. About 50 participants will be randomly assigned to either start the practice right away or join a waitlist. They w…

This study tests whether a mobile app called JoyPop can help 110 youth aged 12-17 who are on a waitlist for mental health services. Participants will either use the app or continue with usual care while they wait. The goal is to see if the app improves emotion regulation and redu…

This study looks at whether cannabidiol (CBD) can reduce stress and withdrawal symptoms in people who smoke cigarettes. About 90 smokers will take CBD and then be exposed to stress. Researchers will measure mood, pain, heart rate, and stress hormones to see if CBD helps. Some par…

This study looks at whether music therapy can improve mental health and social connections in university students who are feeling depressed, anxious, or stressed. Twenty students will be randomly assigned to either a music therapy group (writing songs) or a control group (listeni…

This study looks at whether swaddling (wrapping snugly) or nesting (creating a cozy boundary) can lower pain and stress in newborns who need breathing help. About 100 babies born after 35 weeks will be observed. Researchers will check heart rate, oxygen levels, and use a special …

This study tests whether taking a daily prebiotic fiber powder for 12 weeks can lower stress levels in healthy adults who feel mild to severe stress. Researchers will also check effects on mood, inflammation, and gut bacteria. About 156 people will take either the fiber blend or …

This study tests whether personalized music playlists can lower stress, anxiety, and depression in adults. 2000 participants will be randomly assigned to either listen to custom playlists or receive no music intervention. The goal is to see if music can be a simple, non-drug tool…

This study is testing whether a daily supplement called AGZ can help adults aged 25-59 who have trouble sleeping feel more relaxed in the evening, sleep better, and wake up feeling refreshed. Three hundred participants will take the supplement or a placebo for 30 days and answer …

This study looks at whether a 6-week online mindfulness-based stress reduction (MBSR) program can lower stress, anxiety, depression, and other side effects in women with breast cancer who are starting chemotherapy. About 200 participants will be randomly assigned to either the MB…

This study tests a program called ACT Together for parents of children with disabilities. The program includes six online lessons and weekly phone coaching sessions with a therapist. It teaches skills to handle stress and difficult emotions. Researchers want to see if the program…

This study tests whether a 4-week digital program that sends activity prompts can increase physical activity and reduce depression, anxiety, and stress in adults with moderate depressive symptoms. About 50 participants will be randomly assigned to receive the program or just have…

This study tests whether inhaling lavender essential oil for four weeks can improve mental health in women waiting for IVF treatment. 120 participants will be split into three groups: one using real lavender oil, one using a placebo scent, and one receiving no treatment. The goal…

This study tests a mobile app called Blueprint that teaches coping skills to people who survived a serious illness in the ICU. Many survivors face depression, anxiety, and PTSD, but mental health care is hard to access. The app aims to reduce these symptoms and improve quality of…

This study is testing whether taking a daily postbiotic supplement called Humiome® Post LB for three months can help lower stress levels in adults aged 50 to 75. About 200 people in France will take either the supplement or a placebo pill, and neither they nor the researchers wil…

This study tests a new 8-week online program called MB-Spirit designed to improve well-being in stressed adults. Participants will attend weekly classes, fill out questionnaires, and get two MRI brain scans. The goal is to see if the program reduces stress and changes brain activ…

This study looks at whether listening to live or recorded music can help lower stress, pain, and anxiety in people about to have brain surgery. About 132 patients will take part. Researchers will check things like heart rate, blood pressure, and mood before and after the music se…

This study tests a 6-week online psychological coaching program for NSU undergraduate students. The goal is to help reduce anxiety, depression, and stress while improving quality of life and coping skills. About 160 students will participate, and the program is free.

This study looks at whether combining neurofeedback (a brain training technique) with mindfulness can lower anxiety and stress in nursing students. About 36 students will try this approach for 4 weeks. The goal is to see if it helps them feel better and do better in school.

This study tests a workplace program that combines mind-body techniques, self-care strategies, and special nutrition to help healthcare workers handle stress better. About 252 employees from a German hospital will take part. If it works, the program could be offered to all hospit…

This study tests a mobile app program called PRISM to help teens and young adults (ages 12-25) who have finished cancer treatment learn skills to manage stress and build resilience. Participants will use the app for six sessions and complete surveys about their well-being. The go…

This study tests whether a nutritional supplement called 'Think Tank' can help middle-aged women (40-60 years old) think better after experiencing stress. Forty healthy female daily caffeine drinkers will take either the supplement or a placebo and then complete thinking and memo…

This study tests whether natural supplements (lavender oil, PEA, and OEA) can improve sleep and reduce stress in adults with moderate sleep problems and stress. About 240 generally healthy adults will take a daily capsule for 8 weeks, comparing three active supplements to a place…

This study looks at whether Reiki, a non-invasive therapy where a practitioner lightly places hands near the body, can help adults with cancer who feel very tired from immunotherapy. Twelve participants will either receive six weekly Reiki sessions or wait, then switch. Researche…

This study tests whether the JoyPop app can help Indigenous youth aged 18-25 in Northwestern Ontario manage emotions, depression, and anxiety while they wait for mental health services. About 110 participants will use the app or continue with usual care. The goal is to see if the…

This study tests whether a tonic called Feel Free® Classic can help healthy adults feel less stressed. About 165 people aged 21-55 with mild to moderate stress will take the tonic or a placebo for 29 days. Researchers will measure stress levels and how the body processes the toni…

This study tests whether adding a special supplement to a mindfulness program helps college students aged 18-25 feel less stressed, anxious, or depressed. About 120 students with high stress will join one of three groups: mindfulness only, mindfulness plus supplement, or a health…

This study tests whether a daily nasal spray of oxytocin, a natural hormone, can lower stress and improve quality of life in female family caregivers of people with dementia. About 32 women aged 50 and older who provide unpaid care will receive either a low dose, a higher dose, o…

This study tests a new online, self-guided course based on dialectical behavior therapy (DBT) for adults with mild-to-moderate depression or anxiety. Up to 40 participants in Ontario will use the 8-week program and complete surveys to see if it is easy to use and helpful. The goa…

This study tests whether a smartphone app called JoyPop can help young adults (ages 18-25) better manage their emotions, anxiety, and depression while they wait for mental health services. About 110 participants from Northwestern Ontario will either use the app or continue with u…

This study compares two breathing techniques (cyclic sighing and box breathing) with hypnosis and listening to an audiobook about stress. Researchers want to see if these practices can lower anxiety right away and after four weeks of daily use. About 80 adults will participate, a…

This study tests whether a one-week smartphone training program can help unpaid caregivers of people with Alzheimer's disease manage stress and emotions better. About 270 caregivers will learn either distancing or reinterpretation techniques, or receive no training. Researchers w…

This study tests whether using virtual reality (VR) goggles or a sedative drug called dexmedetomidine is better at reducing anxiety and stress in women having a planned cesarean section. About 52 mothers will be randomly assigned to one of the two methods. The goal is to find a s…

This study tests whether a 10-session parenting program called Attachment and Biobehavioral Catch-up (ABC) can reduce stress-related biomarkers in children aged 2 to 3 who have experienced early life challenges. About 150 caregiver-child pairs will be randomly assigned to receive…

This study looks at whether giving parents of children with chronic conditions a mental health questionnaire during clinic visits can help spot stress, anxiety, or depression. About 100 parents will fill out the survey, get their results and a list of support services, and be che…

This study looks at whether using video recordings from an 'Operating Room Black Box' during team debriefings after surgery helps healthcare workers feel more psychologically safe and work better together. About 135 operating room staff from three hospitals will take part. The go…

This study looks at how sleep problems and stress can trigger migraine attacks in adults. About 80 people with episodic migraine will wear a WHOOP band to track sleep and body signals, and answer daily questions via a smartphone app. The goal is to find personal patterns and give…

This study looks at how nomophobia—the fear of being without your smartphone—relates to stress, food addiction, and body image in 150 university students aged 18-30. Researchers will use surveys and body measurements to find connections. The goal is to understand these relationsh…

This study explores whether playing music, with or without a parent's voice, can lower stress and improve brain development in very preterm infants (born 24-30 weeks). About 243 babies from two hospitals will be randomly assigned to music, music plus parent voice, or standard car…

This study tests a program called FRAME that helps heart failure patients talk about mental health with their doctors and family. About 7,300 adults with heart failure or at risk for it will take part. The goal is to see if the program makes it easier for patients to get mental h…

This study looks at how short-term stress affects the brain's energy use and connections. Sixty-eight healthy adults will have two brain scans (PET/MRI) one week apart while doing a stress test. Researchers will measure glucose metabolism, brain connectivity, and stress hormone l…

This study looks at how stress and childhood trauma might increase the risk of preterm birth, especially in Black and Hispanic women. Researchers will study mitochondria, the energy centers of cells, to understand how stress gets "under the skin" and affects pregnancy. The goal i…

This study looks at how a brief full-body cold-water bath, compared to a warm bath, influences decision-making, mood, and physical responses. Researchers will measure things like risk-taking, food choices, heart rate, and stress hormones in 40 healthy adults. The goal is to under…

This study is testing whether a smartphone app can help firefighters improve their sleep, thinking, and overall health. About 50 firefighters will use the app and report on their sleep habits. The goal is to see if the program is easy to use and helpful for this group.

This study looks at how body composition (fat vs. muscle) affects blood vessel health in women who have a normal BMI. Researchers will measure how blood vessels respond to a high-fat meal and a stress task. The goal is to understand why some normal-weight women may still have hig…

This study looks at how negative feelings like stress, pain, or hunger change the way healthy adults make decisions. About 900 people aged 18 to 55 will experience different emotional triggers, such as watching a stressful video or fasting, then perform computer tasks and sometim…

This study tests a training program called ASCEND, developed by the World Health Organization, for supervisors in small and medium-sized Dutch companies. The goal is to see if the training helps supervisors better support their employees' mental health, reduce stress and burnout,…

This study looks at how searching the internet for health information affects stress and emotional well-being in women undergoing infertility treatment. Researchers will survey 201 women about their online search habits, stress levels, and emotional health. The goal is to underst…

This study explores how poor sleep during pregnancy may increase the risk of stress and mental health problems after giving birth. Researchers will follow 114 pregnant women, measuring sleep quality, stress hormones, and mood. They will also test an online program designed to imp…

This study looks at how adding chia seeds (a fiber source) to your diet changes the bacteria in your gut. Healthy adults in California, Arizona, and Pennsylvania will take fiber for two months and provide stool and blood samples. The goal is to understand how diet and stress affe…

This study looks at how cannabidiol (CBD), a non-intoxicating cannabis compound, affects the brain and body's response to stress. Researchers will recruit 160 young adults aged 18-25 who experienced early life adversity. Participants will undergo brain scans, hormone tests, and s…

This study looks at how healthy behaviors like diet, exercise, stress, and sleep relate to heart health in both adults and children. Researchers will collect data from questionnaires and simple health checks like blood pressure and blood sugar. The goal is to better understand th…

This study looks at why depression and heart disease often happen together in women going through menopause. Researchers will measure stress-related chemicals and heart rate in 30 women aged 44-55. The goal is to find clues that could lead to better prevention and treatment.

This study looks at how stressful experiences in childhood may impact heart and blood vessel health later in life. Researchers will measure heart function, blood vessel response, and lung function in 120 people aged 9 to 30. No treatments or medications are given—the goal is simp…

This study looks at how stress changes the way opioid pain medications work in people with long-term back pain. Researchers want to understand if high stress levels make these drugs more likely to be misused. The study involves 120 adults and uses questionnaires and lab tests to …

This study tests whether a 14-day mobile diary is a practical way to measure daily stress and thinking performance in breast cancer survivors. Researchers will enroll 30 racially diverse women aged 40 and older who are at least five years past diagnosis. Participants complete sho…

This study tests whether an 8-week online stress reduction program called RiSE can improve well-being, reduce inflammation, and change DNA markers in African American women aged 50-75 who have risk factors for heart or metabolic disease. Participants are randomly assigned to eith…

This study looks at whether an 8-week stress reduction program can lower inflammation in the arteries of adults with stable heart disease. Participants must feel stressed and have a history of heart problems. Researchers will use special PET/MRI scans to measure changes in inflam…

This study looks at how stress, pain, and the immune system interact in people living with HIV who also have cannabis use disorder and depression. Researchers will measure stress hormones, pain levels, and heart rate during a pain stress task. The goal is to better understand the…