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Daily pill aims to tackle weight and diabetes together

NCT ID NCT07654374

Disease control Sponsor: Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 5 times

Summary

This phase 3 study tests aleniglipron, an oral medication taken once daily, for helping adults with obesity or overweight and type 2 diabetes manage their weight over the long term. Participants receive either aleniglipron or a placebo for 76 weeks. The main goal is to see how much body weight changes from the start of the study.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
aleniglipron
What this could lead to
If successful, aleniglipron could offer a convenient daily pill for significant weight loss and better blood sugar control in people with obesity and type 2 diabetes.
What could go wrong
This is a long-term study, and results may not match earlier phases. Side effects or lack of sustained benefit could limit its use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 1,100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 79 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Signed Informed Consent * Have a BMI ≥27.0 kg/m2 at Screening * Have a diagnosis of T2DM according to the WHO classification or other locally applicable standards, with HbA1c ≥6.5% (≥53 mmol/mol) to ≤10% (86 mmol/mol) at Screening Exclusion Criteria: * Have type 1 diabetes, history of ketoacidosis or hyperosmolar state/coma, or any other types of diabetes except T2DM. * Have had 1 or more episode of severe hypoglycemia and/or 1 or more episode of hypoglycemia unawareness within 180 days prior to Screening. * Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema * Self-reported change in body weight \>5 kg (11 pounds) within 3 months before Screening. * Have prior or planned surgical or non-surgical treatment for obesity.

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Get notified about this study

Sign up to get updates when this study changes or when new studies for Chronic weight management are added.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic weight management Obesity Overweight TYPE2 diabetes mellitus

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    74 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Birmingham, Alabama, 35242, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Chandler, Arizona, 85225, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Phoenix, Arizona, 85028, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Sun City West, Arizona, 85375, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Tucson, Arizona, 85741, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Little Rock, Arkansas, 72211, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Escondido, California, 92025, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Fountain Valley, California, 92708, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    La Jolla, California, 92123, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Lake Forest, California, 92630, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Rolling Hills Estates, California, 90274, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    San Diego, California, 92108, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Tustin, California, 92780, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Waterbury, Connecticut, 06708, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Clearwater, Florida, 33756, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Fort Myers, Florida, 33912, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Jacksonville, Florida, 32216, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Leesburg, Florida, 34748, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Miami, Florida, 33136, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Ocala, Florida, 34470, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Ocoee, Florida, 34761, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Pembroke Pines, Florida, 33027, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Atlanta, Georgia, 30329, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Columbus, Georgia, 31904, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Lawrenceville, Georgia, 30046, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Union City, Georgia, 30291, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Woodstock, Georgia, 30189, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Meridian, Idaho, 83646, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Des Moines, Iowa, 50314, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Iowa City, Iowa, 52242, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Wichita, Kansas, 67218, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Silver Spring, Maryland, 20901, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Methuen, Massachusetts, 01844, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Mankato, Minnesota, 56001, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Minneapolis, Minnesota, 55423, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Gulfport, Mississippi, 39503, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Ridgeland, Mississippi, 39157, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Chesterfield, Missouri, 63005, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    City of Saint Peters, Missouri, 63303, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Hazelwood, Missouri, 63042, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Springfield, Missouri, 65807, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    St Louis, Missouri, 63141, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Missoula, Montana, 59804, United States

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Omaha, Nebraska, 68105, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Las Vegas, Nevada, 89128, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Albany, New York, 12206, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Albany, New York, 12208, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Brooklyn, New York, 11220, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    The Bronx, New York, 10455, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Charlotte, North Carolina, 28210, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Durham, North Carolina, 27710, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Fayetteville, North Carolina, 28304, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Morehead City, North Carolina, 23730, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Winston-Salem, North Carolina, 27104, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Columbus, Ohio, 43213, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Moore, Oklahoma, 73160, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Tulsa, Oklahoma, 74133, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Yukon, Oklahoma, 73099, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Portland, Oregon, 97202, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Philadelphia, Pennsylvania, 19152, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Greer, South Carolina, 29651, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Austin, Texas, 78704, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Farmers Branch, Texas, 75234, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Houston, Texas, 77040, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Houston, Texas, 77054, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    San Antonio, Texas, 78229, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    San Antonio, Texas, 78230, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Wylie, Texas, 75098, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Salt Lake City, Utah, 84107, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    NOT_YET_RECRUITING

    Burke, Virginia, 22015, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Manassas, Virginia, 20110, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Suffolk, Virginia, 23435, United States

    Contact Email: •••••@•••••

  • ACCOMPLISH-2 Research Site

    RECRUITING

    Renton, Washington, 98057, United States

    Contact Email: •••••@•••••

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