A new multi-test approach may spot hidden blood vessel damage before symptoms appear

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

INCLUSION CRITERIA * Age 18 years or older. * Written informed consent to participate in the registry. * Undergoing cardiovascular risk or hypertension assessment in a primary-prevention setting. * At least one of the following cardiovascular risk conditions: * Confirmed hypertension requiring specialist cardiovascular assessment. * A SCORE2 estimated 10-year cardiovascular risk of 2% or higher in participants aged 40 to 69 years, when SCORE2 is applicable. * A SCORE2-OP estimated 10-year cardiovascular risk of 2% or higher in participants aged 70 to 89 years, when SCORE2-OP is applicable. * Type 2 diabetes with at least moderate cardiovascular risk according to SCORE2-Diabetes in participants within its validated age range, or according to guideline-defined clinical risk criteria when SCORE2-Diabetes is not applicable. * Chronic kidney disease confirmed for at least 3 months, defined by an estimated glomerular filtration rate below 60 mL/min/1.73 m², a urinary albumin-to-creatinine ratio of 30 mg/g or higher, or another persistent marker of kidney damage. * Hypertension-mediated target-organ damage or subclinical atherosclerotic vascular disease documented by clinical, laboratory, imaging, or functional assessment. * Confirmed or probable familial hypercholesterolemia. * For participants aged 18 to 39 years or older than 89 years, a documented major cardiovascular risk condition, such as hypertension, type 2 diabetes, chronic kidney disease, familial hypercholesterolemia, or target-organ damage. EXCLUSION CRITERIA * Inability or unwillingness to provide written informed consent. * Established clinical cardiovascular disease requiring secondary-prevention management, including previous myocardial infarction, acute coronary syndrome, stroke, transient ischemic attack, coronary or peripheral revascularization, symptomatic peripheral artery disease, or other established symptomatic cardiovascular disease. * Acute or clinically unstable illness that prevents completion of the baseline registry assessment. * A medical, technical, cognitive, or logistical condition that prevents completion of the minimum required registry procedures.