Brazilian diabetes prevention program aims to stop type 2 diabetes before it starts
NCT ID NCT06426277
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a 3-year lifestyle program for 1,305 Brazilian adults at high risk for type 2 diabetes. The program combines in-person and online counseling on diet, exercise, sleep, and stress. Researchers will track who develops diabetes and measure weight, blood sugar, and quality of life.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- structured lifestyle intervention (diet, exercise, sleep, stress management counseling)
- What this could lead to
- If successful, this program could offer an effective, scalable way to prevent type 2 diabetes in high-risk populations, reducing the burden of the disease.
- What could go wrong
- This is a large trial but still early in real-world application. Lifestyle changes are hard to maintain, and results may vary by individual or community factors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 1,305 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2024
- Expected to finish
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Dec 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Be 18 years or older (no maximum age for being eligible) * Have a body mass index (BMI) between 18,5 and 34,9kg/m² * Have, at least, one electronic device (includes any of the following devices): * Computer * Laptop/notebook * Tablet * Smartphone * Have access to internet (broadband, 3G, 4G, 5G, among others) Without previous nutritional counseling (within the 6 months prior to recruitment/randomization/intervention) Without supervision by a Physical Education Professional (Personal Trainer) in the past 6 months * Living near the research center (at maximum 60 minutes) * Diagnosis of prediabetes defined as two HbA1c measurements between 5.7% and 6.4% collected 7 to 90 days apart. Exclusion Criteria: * Diagnosis of Diabetes Mellitus (including current or recent use, within three months, of glucose-lowering medication) * Underlying disease likely to limit life expectancy and/or increase the risk of interventions influencing the risk of developing T2D * Diagnosis of Renal Disease * Diagnosis of Pulmonary Disease * Gastrointestinal Disease * Secondary prevention for Cardiovascular Disease * Endocrine Diseases * Weight loss exceeding 10% in the last 6 months (except postpartum-related) * Uncontrolled Hypertension * Diagnosis of Polycystic Ovary Syndrome (self-reported) * Patients undergoing treatment for Tuberculosis (except those using isoniazid \[INH\] as prophylaxis) * Presence of diseases that may severely reduce life expectancy or the ability to participate in the study * Pregnant or breastfeeding women * Severe psychiatric disorders that, in the opinion of the clinical team, hinder participation in the program * Acute or chronic excessive alcohol consumption * Congestive Heart Failure (CHF) with a New York Heart Association Functional Class (NYHA) \> 2 * Need for referral to a cardiologist according to the Physical Activity Readiness Questionnaire (PAR-Q) * Current or recent participation (within the last six months) in another clinical trial that impacts the interventions and/or is associated with the study outcomes (in case of doubt, contact the coordinating center) * Likely relocation away from the research collaborating center within the next 3 years * Another household member is a participant or a team member of the PROVEN-DIA study * Unwillingness to accept treatment assignment by randomization and/or refusal to participate in the study (signing the Informed Consent Form) * Continuous use of the following medications: Corticosteroids other than topical, ophthalmic, or inhaled preparations Antineoplastic agents Psychoactive agents Other medications. • Participant from the pilot Randomized Clinical Trial (Brazilian Diabetes Prevention Program: Pilot Study (PROVEN-Dia), NCT05689658)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Hospital de Clínicas de Goiás - UFG
RECRUITINGGoiânia, Goiás, Brazil
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Universidade Federal de Viçosa
RECRUITINGViçosa, Minas Gerais, Brazil
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