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Brazilian diabetes prevention program aims to stop type 2 diabetes before it starts

NCT ID NCT06426277

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a 3-year lifestyle program for 1,305 Brazilian adults at high risk for type 2 diabetes. The program combines in-person and online counseling on diet, exercise, sleep, and stress. Researchers will track who develops diabetes and measure weight, blood sugar, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
structured lifestyle intervention (diet, exercise, sleep, stress management counseling)
What this could lead to
If successful, this program could offer an effective, scalable way to prevent type 2 diabetes in high-risk populations, reducing the burden of the disease.
What could go wrong
This is a large trial but still early in real-world application. Lifestyle changes are hard to maintain, and results may vary by individual or community factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,305 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2024

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Be 18 years or older (no maximum age for being eligible) * Have a body mass index (BMI) between 18,5 and 34,9kg/m² * Have, at least, one electronic device (includes any of the following devices): * Computer * Laptop/notebook * Tablet * Smartphone * Have access to internet (broadband, 3G, 4G, 5G, among others) Without previous nutritional counseling (within the 6 months prior to recruitment/randomization/intervention) Without supervision by a Physical Education Professional (Personal Trainer) in the past 6 months * Living near the research center (at maximum 60 minutes) * Diagnosis of prediabetes defined as two HbA1c measurements between 5.7% and 6.4% collected 7 to 90 days apart. Exclusion Criteria: * Diagnosis of Diabetes Mellitus (including current or recent use, within three months, of glucose-lowering medication) * Underlying disease likely to limit life expectancy and/or increase the risk of interventions influencing the risk of developing T2D * Diagnosis of Renal Disease * Diagnosis of Pulmonary Disease * Gastrointestinal Disease * Secondary prevention for Cardiovascular Disease * Endocrine Diseases * Weight loss exceeding 10% in the last 6 months (except postpartum-related) * Uncontrolled Hypertension * Diagnosis of Polycystic Ovary Syndrome (self-reported) * Patients undergoing treatment for Tuberculosis (except those using isoniazid \[INH\] as prophylaxis) * Presence of diseases that may severely reduce life expectancy or the ability to participate in the study * Pregnant or breastfeeding women * Severe psychiatric disorders that, in the opinion of the clinical team, hinder participation in the program * Acute or chronic excessive alcohol consumption * Congestive Heart Failure (CHF) with a New York Heart Association Functional Class (NYHA) \> 2 * Need for referral to a cardiologist according to the Physical Activity Readiness Questionnaire (PAR-Q) * Current or recent participation (within the last six months) in another clinical trial that impacts the interventions and/or is associated with the study outcomes (in case of doubt, contact the coordinating center) * Likely relocation away from the research collaborating center within the next 3 years * Another household member is a participant or a team member of the PROVEN-DIA study * Unwillingness to accept treatment assignment by randomization and/or refusal to participate in the study (signing the Informed Consent Form) * Continuous use of the following medications: Corticosteroids other than topical, ophthalmic, or inhaled preparations Antineoplastic agents Psychoactive agents Other medications. • Participant from the pilot Randomized Clinical Trial (Brazilian Diabetes Prevention Program: Pilot Study (PROVEN-Dia), NCT05689658)

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital de Clínicas de Goiás - UFG

    RECRUITING

    Goiânia, Goiás, Brazil

  • Universidade Federal de Viçosa

    RECRUITING

    Viçosa, Minas Gerais, Brazil

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