PREDIABETIC STATE

This study looks at whether eating all your food within a specific 9-hour window each day (time-restricted eating) can improve blood sugar control in people with obesity who have or are at risk for type 2 diabetes. Researchers will compare three different eating windows to see if…

This study tests if applying heat pads to the legs can improve blood sugar control and muscle health in older adults with prediabetes, similar to high-intensity interval training. Researchers will compare heat therapy to exercise in 54 sedentary adults aged 50 and older. The goal…

This study looks at whether treating insomnia with cognitive behavioral therapy (CBT-I) can lower blood sugar levels in people with prediabetes. About 300 adults with both prediabetes and insomnia will either receive CBT-I or a general health education program. The goal is to see…

This study tests whether adding hands-on nutrition demonstrations helps people at risk for prediabetes stay in the Diabetes Prevention Program. About 20 adults who are eligible for the program will take part. The goal is to see if this approach improves participation and health h…

This study tests whether metformin, a common diabetes medicine, can lower the risk of death, heart attacks, and strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,400 participants will be followed over time to see if metformin helps …

This study aims to identify early risk factors for Alzheimer's disease by following 850 adults with normal memory or mild cognitive issues. Researchers will track changes in thinking skills, brain scans, and spinal fluid markers over time, with a special focus on how blood sugar …

This study looks at how aging changes the way our bodies respond to exercise. Researchers will have 26 older adults who previously completed an exercise program do another 6 months of aerobic training. The goal is to measure changes in insulin sensitivity, fitness, and overall he…

This study aims to understand how insulin controls sugar and fat production in the liver, comparing healthy adults to those at risk for type 2 diabetes. Participants will receive a single dose of the drug alpelisib or a placebo during two overnight hospital stays. Researchers wil…

This study looks at whether a one-week course of the drug diazoxide can reduce how much fat the liver makes in people with obesity, insulin resistance, and a type of fatty liver disease called MASLD. About 25 adults will take either the drug or a placebo, and researchers will mea…

This study looks at whether resistance training (like lifting weights) can improve how fat is broken down in obese postmenopausal women who have prediabetes. Researchers will measure fat metabolism before and after 12 weeks of training. The goal is to find a practical way to prev…