PREDIABETIC STATE

This study is testing if the timing of daily eating affects blood sugar control. Researchers are comparing three different 9-hour eating windows in 120 adults with obesity who have type 2 diabetes or are at risk for it. The goal is to see if starting meals early, mid-day, or late…

This study is testing whether applying heat pads to the legs can improve blood sugar control and muscle health in older adults with prediabetes. Researchers will compare the effects of daily heat therapy to a standard exercise program and to a control group. The goal is to see if…

This study is testing whether an online program that teaches better sleep habits can help prevent type 2 diabetes in people with prediabetes and insomnia. Researchers will compare the sleep therapy program against general sleep education to see which better lowers blood sugar lev…

This large VA study is testing whether metformin, a common diabetes medication, can prevent heart attacks, strokes, and death in veterans who have pre-diabetes and existing heart or blood vessel disease. Over 7,400 participants will receive either metformin or a placebo pill, alo…

This small pilot study is testing whether adding hands-on cooking classes makes a standard diabetes prevention program more appealing and easier for people to stick with. Researchers will work with 20 adults at risk for diabetes at two Los Angeles community health centers. The go…

This study aims to understand how the hormone insulin works differently in healthy people compared to those at risk for type 2 diabetes and fatty liver disease. Researchers will give a single dose of a drug called alpelisib or a placebo to 32 participants during two separate over…

This study aims to identify early risk factors that predict cognitive decline and Alzheimer's disease in adults aged 55 and older. Researchers will follow 850 participants with normal cognition, mild impairment, or early Alzheimer's to track how metabolic health and brain changes…

This study aims to understand how aging changes the way our bodies respond to exercise, especially for older adults with prediabetes or related heart and metabolic risks. It will enroll 26 people who previously completed an exercise study to participate in a new 6-month aerobic e…