Afternoon workouts may beat morning exercise for blood sugar control

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pre-diabetes: * Fasting plasma glucose: 6.1 to 6.9 mmol/L or * 2-hour plasma glucose post 75g OGTT: 7.8 to 11.0 mmol/L and * HbA1c: 6.0 to 6.4% * or Insulin resistant: glucose clearance rate ≤ 360 ml/kg/min as determined using the Oral Glucose Insulin Sensitivity Index at Time 120 min. * BMI \> 25 kg/m2 * To be willing and able to adhere to the specifications of the protocol; * To have signed an informed consent document indicating that they understood the purpose of and procedures required for the study and were willing to participate in the study. Exclusion Criteria: * overt cardiovascular disease as assessed by medical history, physical exam, and abnormal ECG * Treatment with any drug known to affect lipid or carbohydrate metabolism, except statins (to be stopped 3 weeks prior to study A), metformin or anti-hypertensive drugs (to be stopped 7 days prior to the studies); * presence of liver or renal disease other than uncomplicated NASH or mild isolated proteinuria; uncontrolled thyroid disorder; * Uncontrolled severe hypertension, systolic pressure ≥ 180 mm Hg or diastolic pressure ≥ 110 mm Hg; * History of ischemic heart disease, tachyarrhythmia, QT interval prolongation, risk factors for torsade de pointes (eg hypokalemia), or taking any medication known to prolong the QT interval; * History of serious gastrointestinal disorders (malabsorption, peptic ulcer, gastroesophageal reflux requiring surgery, etc.); * Presence of a pacemaker; * Having undergone a PET study or CT scan in the past year; * Any contraindication to stopping statins for 3 months and stopping an anti-hypertensive medication and metformin for 7 days; * smoking (\>1 cigarette/day) and/or consumption of \>2 alcoholic beverages per day; * No blood donation two month prior the study; * prior history or current fasting plasma cholesterol level \> 7 mmol/l or fasting TG \> 6 mmol/l.