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New drug combo aims to protect kidneys in diabetes

NCT ID NCT07271186

Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 5 times

Summary

This Phase 2 trial tests two experimental drugs, ALN-ANG3 and evinacumab, in 270 people with diabetic kidney disease. The drugs block a protein called ANGPTL3 to lower blood fats. Researchers will measure changes in urine protein and kidney function over time to see if the drugs are safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ALN-ANG3 and evinacumab (two experimental drugs that block a protein called ANGPTL3 to lower fats in the blood)
What this could lead to
If successful, this could point toward a new treatment option to slow kidney damage in people with diabetic kidney disease.
What could go wrong
This is a Phase 2 trial with only 270 participants, so results are still early. The drugs may not improve kidney function or could cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 195 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: 1. Medical history of type 2 diabetes and receiving medical therapy or lifestyle interventions for glucose management 2. Hemoglobin A1C (HbA1c) of 6.5 to 10% at screening 3. eGFR 30 to 90 mL/min/1.73 m\^2 using 2021 Chronic Kidney Disease-Epidemiology Collaboration-Estimated Glomerular Filtration Rate using Creatinine and Cystatin C (CKD-EPI eGFRcr-cys) equation at screening 4. Albuminuria: Urine Albumin to Creatinine Ratio (UACR) of 500 to 5000 mg/g at screening Key Exclusion Criteria: 1. Known medical history or clinical evidence indicative of non-diabetic renal disease 2. Renal disease that required treatment with systemic immunosuppressive therapy (prior or current), or a history of end-stage kidney disease requiring treatment with chronic dialysis or kidney transplantation 3. Medically unstable as assessed by the investigator or hospitalization (ie, \>24 hours) within 30 days of the screening visit NOTE: Other Protocol-Defined Inclusion/Exclusion Criteria Apply

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Conditions

The condition(s) this trial relates to.

chronic renal failure syndrome diabetic kidney disease kidney failure type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetic kidney disease (DKD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    58 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AGA Clinical Trials

    RECRUITING

    Hialeah, Florida, 33012, United States

  • AME Clinical Research

    RECRUITING

    Huntington Beach, California, 92647, United States

  • Amicis Research Center

    RECRUITING

    Northridge, California, 91325, United States

  • Amicis Research Center

    RECRUITING

    Santa Clarita, California, 91355, United States

  • Amicis Research Center

    RECRUITING

    Valencia, California, 91355, United States

  • Apogee Clinical Research, LLC

    RECRUITING

    Huntsville, Alabama, 35801, United States

  • Applied Research Center of Arkansas

    RECRUITING

    Little Rock, Arkansas, 72205, United States

  • Arlington Nephrology, PLLC.

    RECRUITING

    Arlington, Texas, 76015, United States

  • Bolanos Clinical Research

    RECRUITING

    Pembroke Pines, Florida, 33026, United States

  • Brookview Hills Research Associates, LLC

    RECRUITING

    Winston-Salem, North Carolina, 27103, United States

  • CDC Research Institute

    RECRUITING

    Port Saint Lucie, Florida, 34952, United States

  • CHEAR Center LLC

    RECRUITING

    The Bronx, New York, 10455, United States

  • Central Coast Nephrology

    RECRUITING

    Salinas, California, 93901, United States

  • Central Florida Kidney Specialists Oakwater

    RECRUITING

    Orlando, Florida, 32806, United States

  • Clinical Advancement Center

    RECRUITING

    San Antonio, Texas, 78212, United States

  • Clinical Research Consultants, LLC

    RECRUITING

    Kansas City, Missouri, 64111, United States

  • Clinical Trial Network, LLC

    RECRUITING

    Houston, Texas, 77074, United States

  • Convenient Medical Center

    RECRUITING

    Hialeah, Florida, 33013, United States

  • D&H Doral Research Center

    RECRUITING

    Doral, Florida, 33122, United States

  • D&H National Research Centers, Inc

    RECRUITING

    Miami, Florida, 33155, United States

  • D&H Pompano Research Center

    RECRUITING

    Margate, Florida, 33063, United States

  • D&H Tamarac Research Center

    RECRUITING

    Tamarac, Florida, 33321, United States

  • DaVita Clinical Research

    RECRUITING

    Las Vegas, Nevada, 89107, United States

  • Eastern Nephrology Associates - Greenville West

    RECRUITING

    Greenville, North Carolina, 27834, United States

  • Eastern Nephrology Associates - New Bern

    RECRUITING

    New Bern, North Carolina, 28562, United States

  • El Paso Kidney Specialists-Davita Clinical Research

    RECRUITING

    El Paso, Texas, 79902, United States

  • Elixia Hollywood

    RECRUITING

    Hollywood, Florida, 33024, United States

  • Elixia MNA

    RECRUITING

    City of Saint Peters, Missouri, 63376, United States

  • Elixia Michigan Kidney Consultants

    RECRUITING

    Pontiac, Michigan, 48341, United States

  • Epic Medical Research LLC

    RECRUITING

    DeSoto, Texas, 75115, United States

  • FOMAT - Vista del Mar Medical Group

    RECRUITING

    Oxnard, California, 93036, United States

  • Gulf Coast Clinical Research

    RECRUITING

    Katy, Texas, 77450, United States

  • IMA Clinical Research

    RECRUITING

    Monroe, Louisiana, 71201, United States

  • Innovia Research Center

    RECRUITING

    Miramar, Florida, 33027, United States

  • Juno Research, LLC

    RECRUITING

    Houston, Texas, 77040, United States

  • LCC Medical Research Institute

    RECRUITING

    Miami, Florida, 33126, United States

  • M3 Wake Research Dallas - Internal Medicine

    RECRUITING

    Dallas, Texas, 75224, United States

  • Metabolic Research Institute

    RECRUITING

    West Palm Beach, Florida, 33401, United States

  • National Institute of Clinical Research, Inc.

    RECRUITING

    Victorville, California, 92392, United States

  • North America Research Institute

    RECRUITING

    San Dimas, California, 91773, United States

  • Northeast Clinical Research Center

    RECRUITING

    Bethlehem, Pennsylvania, 18017, United States

  • Ocean Blue Medical Research Center - Internal Medicine

    RECRUITING

    Miami Springs, Florida, 33166, United States

  • Privia Medical Group of Georgia, LLC

    RECRUITING

    Savannah, Georgia, 31406, United States

  • Progressive Medical Research

    RECRUITING

    Port Orange, Florida, 32127, United States

  • Prolato Research LLC

    RECRUITING

    Houston, Texas, 77054, United States

  • R & H Clinical Research, Inc.

    RECRUITING

    Katy, Texas, 77450, United States

  • Regenerate Primary Medical Research, LLC

    RECRUITING

    Miami, Florida, 33155, United States

  • Research by Design, LLC - Internal Medicine

    RECRUITING

    Chicago, Illinois, 60643, United States

  • Revival Research Institute, LLC

    RECRUITING

    Dallas, Texas, 75231, United States

  • Southeast Renal Research Institute

    RECRUITING

    Chattanooga, Tennessee, 37404, United States

  • Suburban Research Associates

    RECRUITING

    West Chester, Pennsylvania, 19380, United States

  • Sunbeam Clinical Research

    RECRUITING

    McKinney, Texas, 75069, United States

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198, United States

  • University of Texas Health - San Antonio

    RECRUITING

    San Antonio, Texas, 78229, United States

  • Valiance Clinical Research

    RECRUITING

    Tarzana, California, 91356, United States

  • Velocity Clinical Research

    RECRUITING

    Binghamton, New York, 13905, United States

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06510, United States

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