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New weekly shot could transform diabetes care

NCT ID NCT07415954

Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 11, 2026 · Updated 6 times

Summary

This study tests a new once-weekly injection called NNC0662-0419 in 270 adults with type 2 diabetes. It compares the drug against a placebo and an approved medication, semaglutide, to see how well it controls blood sugar and promotes weight loss. The trial is currently recruiting participants aged 18-75 with HbA1c levels between 7.0% and 10.0%.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NNC0662-0419 (a new weekly injection for diabetes)
What this could lead to
If it works, this could offer a new once-weekly option to help control blood sugar and support weight loss in people with type 2 diabetes.
What could go wrong
This is an early phase 2 dose-finding study, so it is not yet proven effective or safe. The new drug may not work better than existing treatments like semaglutide, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 270 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria * Male or female (sex at birth). * Age 18-75 years (both inclusive) at the time of signing the informed consent. * Glycated haemoglobin (HbA1c) of 7.0-10.0 percent (%) (53-86 millimoles per mole \[mmol/mol\]) (both inclusive) as assessed by central laboratory at screening. * Willingness to obtain a high weight loss (greater than \[\>\] 25% of weight at baseline). Exclusion criteria * Treatment with any medication for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening. However, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed. * Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination. * Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's Questionnaire.

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

diabetes mellitus type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus type 2

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    58 sites in 9 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • "Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik

    RECRUITING

    Bialystok, Podlaskie Voivodeship, 15-351, Poland

  • ABS La Roca CAP Vicenç_Endocrino

    RECRUITING

    La Roca Del Vallés, Barcelona, 08430, Spain

  • Akaicho Clinic_Internal medicine

    ACTIVE_NOT_RECRUITING

    Chiba-shi, Chiba, 260-0804, Japan

  • Ark Clinical Research

    RECRUITING

    Long Beach, California, 90815, United States

  • Bioclinical Research Alliance

    RECRUITING

    Miami, Florida, 33155, United States

  • Brigham & Women's Hospital

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02115-5804, United States

  • CNS Healthcare

    RECRUITING

    Memphis, Tennessee, 38119, United States

  • Cardiolima Centro Diagnostico Cardio-Pulmonar De Ponte De Lima Lda

    RECRUITING

    Ponte de Lima, 4990-029, Portugal

  • Casa De Saúde De Santa Filomena S.A._Unidade de Ensaios Clínicos

    RECRUITING

    Coimbra, 3000-150, Portugal

  • Cedar-Crosse Research Center

    RECRUITING

    Chicago, Illinois, 60607, United States

  • Centro de Salud A Estrada

    NOT_YET_RECRUITING

    A Estrada, 36680, Spain

  • Centro de Saúde Concepción Arenal

    RECRUITING

    Santiago de Compostela, 15701, Spain

  • Clínica Bofill

    RECRUITING

    Girona, 17002, Spain

  • Consano Clinical Research, LLC

    RECRUITING

    Shavano Park, Texas, 78231, United States

  • DIADA, s.r.o.

    RECRUITING

    Bardejov, 08501, Slovakia

  • Debreceni Egyetem

    NOT_YET_RECRUITING

    Debrecen, Hajdú-Bihar, 4032, Hungary

  • Debreceni Egyetem

    NOT_YET_RECRUITING

    Debrecen, 4031, Hungary

  • Diablo Clinical Research, Inc.

    RECRUITING

    Walnut Creek, California, 94598, United States

  • Diacrin s. r. o.

    RECRUITING

    Bratislava, 83101, Slovakia

  • Elite Clinical Trials

    RECRUITING

    Blackfoot, Idaho, 83221, United States

  • Encore Medical Research LLC

    RECRUITING

    Hollywood, Florida, 33024, United States

  • Encore Medical Research of Weston

    RECRUITING

    Weston, Florida, 33331, United States

  • Equip D´Atencio Primaria Barcelona Sardenya

    RECRUITING

    Barcelona, 08025, Spain

  • First Valley Medical Group

    RECRUITING

    Lancaster, California, 93534, United States

  • Formed 2 Sp. z o.o.

    RECRUITING

    Oświęcim, 32-600, Poland

  • Frontier Clinical Research - Kingwood

    NOT_YET_RECRUITING

    Kingwood, West Virginia, 26537, United States

  • Headlands Research

    RECRUITING

    Springfield, Missouri, 65807, United States

  • Hospital Trofa Saude Senhor do Bonfim S.A_Unidade de Ensaios Clínicos

    RECRUITING

    Vila do Conde, 4480-565, Portugal

  • Hospital Vithas Sevilla

    RECRUITING

    Castilleja de la Cuesta, 41950, Spain

  • Hospital da Luz Arrábida, S.A_Serviço de Endocrinologia

    RECRUITING

    Vila Nova de Gaia, 4400-346, Portugal

  • JCCT- Juno NW Houston

    RECRUITING

    Houston, Texas, 77040, United States

  • Kangbuk Samsung Hospital_Endocrinology

    RECRUITING

    Seoul, 03181, South Korea

  • Korea University Ansan Hospital_Endocrinology

    RECRUITING

    Ansan-si, Gyeonggi-do, 15355, South Korea

  • Maharaj Nakorn Chiang Mai

    RECRUITING

    Chiang Mai, 50200, Thailand

  • Maharat Nakhon Ratchasima Hospital

    RECRUITING

    Nakhon Ratchasima, 30000, Thailand

  • Metabol KLINIK s.r.o.

    RECRUITING

    Bratislava, 811 08, Slovakia

  • Naka Kinen Clinic_Internal medicine

    ACTIVE_NOT_RECRUITING

    Ibaraki, 311-0113, Japan

  • Nowon Eulji Medical Center, Eulji University_Endocrinology

    RECRUITING

    Seoul, 01830, South Korea

  • Opca bolnica Karlovac

    RECRUITING

    Karlovac, 47000, Croatia

  • Opca bolnica Varazdin_Endocrinology

    RECRUITING

    Varaždin, 42 000, Croatia

  • PANSTWOWY INSTYTUT MEDYCZNY MSWiA

    RECRUITING

    Warsaw, 02-507, Poland

  • Pacific Clinical Studies

    RECRUITING

    Los Alamitos, California, 90720, United States

  • PharmQuest

    RECRUITING

    Greensboro, North Carolina, 27408, United States

  • Piedmont Healthcare Statesville

    RECRUITING

    Statesville, North Carolina, 28625, United States

  • Poliklinika SLAVONIJA OSIJEK

    RECRUITING

    Osijek, 31000, Croatia

  • Poliklinika Solmed

    RECRUITING

    Zagreb, 10000, Croatia

  • Providence Center for Clinical Research

    RECRUITING

    Dayton, Ohio, 45439, United States

  • Pusan National University Yangsan Hospital_Family Medicine

    RECRUITING

    Yangsan, Gyeongsangnam-do, 50612, South Korea

  • Ramathibodi Hospital

    RECRUITING

    Bangkok, 10400, Thailand

  • SIN AZUCAR s.r.o.

    RECRUITING

    Malacky, 901 01, Slovakia

  • Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Szyszko

    RECRUITING

    Zabrze, 41-800, Poland

  • Siriraj Hospital

    RECRUITING

    Bangkok, 10700, Thailand

  • Soka Sugiura Internal Medicine Clinic

    ACTIVE_NOT_RECRUITING

    Soka-shi, Saitama, 340-0015, Japan

  • South Broward Research LLC

    RECRUITING

    Miramar, Florida, 33027, United States

  • Srinagarind Hospital

    RECRUITING

    Khon Kaen, 40002, Thailand

  • Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ

    NOT_YET_RECRUITING

    Szeged, Csongrád-Csanád, 6725, Hungary

  • Terpa Sp. z o.o. Sp. k.

    NOT_YET_RECRUITING

    Lublin, 20-333, Poland

  • ToCROM Clinic_Internal Medicine

    ACTIVE_NOT_RECRUITING

    Tokyo, 160-0008, Japan

  • Tokyo-Eki Center-building Clinic_Internal Medicine

    ACTIVE_NOT_RECRUITING

    Tokyo, 103-0027, Japan

  • Torrance Clinical Research Institute, Inc.

    RECRUITING

    Lomita, California, 90717, United States

  • University of Texas Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75390-9302, United States

  • West Orange Endocrinology

    NOT_YET_RECRUITING

    Ocoee, Florida, 34761, United States

  • Wetlin Research Associates, Inc.

    RECRUITING

    San Diego, California, 92120, United States

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Other studies related to the condition(s) this trial covers.