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Cure My Disease

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New weekly shot aims to tackle weight and diabetes together

NCT ID NCT07533175

Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 5 times

Summary

This study tests a once-weekly injection called NNC0487-0111 in 630 adults who are overweight or obese and have type 2 diabetes. Participants receive either the active drug or a placebo for about a year. The main goal is to see how much weight they lose, with additional checks on waist size, blood sugar, and blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 630 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female (sex at birth). * Age 18 years or above at the time of signing informed consent. * Diagnosed with type 2 diabetes mellitus more than equal to (≥) 180 days before screening. * Treatment with lifestyle intervention, and/or 0-3 marketed oral antidiabetic drugs (OAD)s (metformin, α-glucosidase inhibitors (AGI), glinides, sodium-glucose cotransporter 2 inhibitor (SGLT2i), thiazolidinediones, or sulfonylureas (SU) as a single agent or in combination) according to local label. Treatment with oral antidiabetic drugs should be stable (same drug(s), dose and dosing frequency) before screening. * Haemoglobin A1c (HbA1c) 7-10% \[53-86 (millimoles per mole) mmol/mol\] (both inclusive) as measured by the central laboratory at screening. Exclusion Criteria: * Renal impairment with estimated Glomerular Filtration Rate (eGFR) less than (\<) 30 milliliter per minute per meter square (mL/min/1.73 m\^2) \[2021 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula\], at screening. * Participant with diabetic retinopathy or maculopathy who received treatment with retinal photocoagulation, vitrectomy or anti-Vascular Endothelial Growth Factor (anti-VEGF) before screening or are expected to require treatment after screening. Diabetic retinopathy or maculopathy must be verified by an eye examination performed within 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination. * Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's questionnaire question 8. * Recurrent severe hypoglycaemic episodes within the last year as judged by the investigator. * Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus Obesity Overweight

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    72 sites in 10 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • A&C Medical Prime S.R.L.

    NOT_YET_RECRUITING

    Craiova, 200692, Romania

  • A.O.U Policlinico Paolo Giaccone - U.O.C Medicina Interna

    NOT_YET_RECRUITING

    Palermo, Sicily, 90127, Italy

  • ARETEUS s.r.o.

    RECRUITING

    Trebišov, 075 01, Slovakia

  • ARETEUS s.r.o.

    NOT_YET_RECRUITING

    Trebišov, 075 01, Slovakia

  • Asan Medical Center_Endocrinology

    RECRUITING

    Seoul, 05505, South Korea

  • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone - PSD Nutrizione Clinica, Obesità e Metabolismo

    RECRUITING

    Palermo, Sicily, 90127, Italy

  • CEDIR - Centro de diagnóstico y rehabilitación Santa Fe

    RECRUITING

    Santa Fe, S3000FSO, Argentina

  • CMI Dr. Pletea Noemi SRL

    RECRUITING

    Bacau, 600154, Romania

  • CPCLIN - Centro de Pesquisas Clínicas

    RECRUITING

    São Paulo, São Paulo, 01228-200, Brazil

  • Centro de Investigacion Clinica Endocrinologica de Jalisco

    RECRUITING

    Guadalajara, Jalisco, 44670, Mexico

  • Centro de Investigación Clinica de Oaxaca (CICLO)

    RECRUITING

    Oaxaca City, Oaxaca, 68020, Mexico

  • Centro de Pesquisa Clínica do Hospital das Clínicas da Faculdade de Medicina da USP

    RECRUITING

    São Paulo, São Paulo, 05403-000, Brazil

  • Centro médico privado Cemaic

    RECRUITING

    Córdoba, X5008, Argentina

  • Chonnam National University Hospital_Endocrinology

    RECRUITING

    Gwangju, 61469, South Korea

  • Cline Research Center

    RECRUITING

    Curitiba, Paraná, 80030-480, Brazil

  • Clinstile S.A. de C.V.

    RECRUITING

    Col Roma Norte, Mexico City, 06700, Mexico

  • Cmi Dr. Cojocaru Cristina

    RECRUITING

    Constanța, 900512, Romania

  • Consultorio de Endocrinología y Pediatría

    RECRUITING

    Puebla City, 72190, Mexico

  • DEImedi, s. r. o.

    RECRUITING

    Šurany, 942 01, Slovakia

  • DIA - KONTROL s.r.o.

    RECRUITING

    Levice, 93401, Slovakia

  • DRC Kft.

    NOT_YET_RECRUITING

    Balatonfüred, 8230, Hungary

  • Diabet Med SRL

    RECRUITING

    Bucharest, 050913, Romania

  • Diablo Clinical Research, Inc.

    RECRUITING

    Walnut Creek, California, 94598, United States

  • Dip. Med. Chir. delle malattie digestive, epatiche ed endo-meta - UOC Endocrinologia e prevenzione e cura del diabete

    RECRUITING

    Bologna, Emilia-Romagna, 40138, Italy

  • Florida Institute for Clinical Research, LLC

    RECRUITING

    Orlando, Florida, 32825, United States

  • Grande Ospedale Metropolitano Niguarda - Dipartimento Medico Polispecialistico - Diabetologia

    RECRUITING

    Milan, Lombardy, 20159, Italy

  • Headlands Research California, LLC

    COMPLETED

    Escondido, California, 92025, United States

  • IRCCS Ospedale San Raffaele Milano

    RECRUITING

    Milan, 20132, Italy

  • Instituto Nacional de Nutricion - Unidad de Inv de Enf Metab

    RECRUITING

    Distrito Federal, México, D.F., 14080, Mexico

  • International Diabetes Center

    RECRUITING

    Minneapolis, Minnesota, 55416, United States

  • Jacksonville Ctr Clin Res

    RECRUITING

    Jacksonville, Florida, 32216, United States

  • Kynet Recoleta

    RECRUITING

    Buenos Aires, C1119ACU, Argentina

  • Kyunghee University Medical Center_Endocrinology

    RECRUITING

    Seoul, 02447, South Korea

  • M3 Wake Research Chattanooga

    RECRUITING

    Chattanooga, Tennessee, 37421, United States

  • MICA- Medicina e Investigación Cardiometabólica

    RECRUITING

    Manuel Alberti, Buenos Aires, B1669, Argentina

  • Narodny Endokrinologicky a diabetologicky ustav

    RECRUITING

    Ľubochňa, 03491, Slovakia

  • National Clin Res Inc.

    RECRUITING

    Richmond, Virginia, 23294, United States

  • Northeast Research Institute

    RECRUITING

    Fleming Island, Florida, 32003, United States

  • OLIVER - MED s.r.o.

    RECRUITING

    Rimavská Sobota, 979 01, Slovakia

  • Opca bolnica Karlovac

    RECRUITING

    Karlovac, 47000, Croatia

  • Opca bolnica Pula

    RECRUITING

    Pula, 52100, Croatia

  • Opca bolnica Varazdin_Endocrinology

    RECRUITING

    Varaždin, 42 000, Croatia

  • Oviedo Medical Research, LLC

    RECRUITING

    Oviedo, Florida, 32765, United States

  • PUCCAMP - Hospital e Maternidade Celso Pierro

    RECRUITING

    Campinas, São Paulo, 13060-803, Brazil

  • PVN Kutató Kft.

    NOT_YET_RECRUITING

    Budapest, 1102, Hungary

  • Peter Farkas MD, s.r.o.

    RECRUITING

    Šahy, 93601, Slovakia

  • PlanIt Research, PLLC

    RECRUITING

    Houston, Texas, 77079, United States

  • Poli Cardinal Med Srl

    RECRUITING

    Reghin, Mureș County, 545300, Romania

  • Poliklinika SLAVONIJA OSIJEK

    RECRUITING

    Osijek, 31000, Croatia

  • Poliklinika Solmed

    RECRUITING

    Zagreb, 10000, Croatia

  • Poliklinika za oftalmologiju optometriju i neurologiju Lux

    RECRUITING

    Solin, 21210, Croatia

  • S.C. Top Diabet Srl

    RECRUITING

    Craiova, Dolj, 200515, Romania

  • SC Clinica Diabnutrimed S.R.L.

    RECRUITING

    Bucharest, 020359, Romania

  • SC Nutrilife SRL

    RECRUITING

    Bucharest, 013764, Romania

  • Semmelweis Egyetem

    COMPLETED

    Budapest, 1083, Hungary

  • Seoul National University Bundang Hospital_Endocrinology

    RECRUITING

    Seoungnam-si, Gyeonggi-do, 13620, South Korea

  • Seoul National University Hospital_Endocrinology

    RECRUITING

    Seoul, 03080, South Korea

  • Severance Hospital, Yonsei University Health System_Endocrinology

    RECRUITING

    Seoul, 03722, South Korea

  • Somogy Vármegyei Kaposi Mór Oktató Kórház

    NOT_YET_RECRUITING

    Kaposvár, 7400, Hungary

  • Southgate Medical Group, LLP

    RECRUITING

    West Seneca, New York, 14224, United States

  • Spartanburg Medical Research

    RECRUITING

    Spartanburg, South Carolina, 29303, United States

  • Specijalna Bolnica za medicinsku rehabilitaciju Krapinske Toplice_Endocrinology

    RECRUITING

    Krapinske Toplice, 49217, Croatia

  • Specijalna bolnica Thalassotherapia

    RECRUITING

    Opatija, 51 410, Croatia

  • Spital Judetean De Urgenta Satu Mare

    RECRUITING

    Satu Mare, 440055, Romania

  • Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ

    NOT_YET_RECRUITING

    Szeged, Csongrád-Csanád, 6725, Hungary

  • Szent Margit Rendelőintézet Nonprofit Kft.

    NOT_YET_RECRUITING

    Budapest, 1032, Hungary

  • The Catholic University of Korea, Yeouido ST. Mary's Hospital_Endocrinology

    RECRUITING

    Seoul, 07345, South Korea

  • Torrance Clinical Research Institute, Inc.

    RECRUITING

    Lomita, California, 90717, United States

  • Trantor 99 Bt

    NOT_YET_RECRUITING

    Budapest, H-1213, Hungary

  • UT Southwestern Med Center

    RECRUITING

    Dallas, Texas, 75390, United States

  • Unidad Medica para la Salud Integral (UMSI)

    RECRUITING

    San Nicolás de los Garza, Nuevo León, 66465, Mexico

  • Univ of Alabama Birmingham

    RECRUITING

    Birmingham, Alabama, 35294, United States

  • Universita Degli Studi Di Roma La Sapienza - Policlinico Umberto I Medicina Sperimentale

    RECRUITING

    Rome, Lazio, 00161, Italy

  • Észak-Pesti Centrumkórház Honvédkórház - Diabetológia Szakrendelés

    NOT_YET_RECRUITING

    Budapest, 1134, Hungary

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Other studies related to the condition(s) this trial covers.