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New obesity drug tirzepatide aims to shed pounds and prevent diabetes

NCT ID NCT07247084

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 10, 2026 · Updated 4 times

Summary

This study tests whether the drug tirzepatide, given once weekly, helps adults with obesity (but without diabetes) lose weight and avoid developing type 2 diabetes. About 3,000 participants will receive either tirzepatide or standard care for up to 5 years. The goal is to see if tirzepatide works better than usual treatments in a real-world setting.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tirzepatide
What this could lead to
If successful, tirzepatide could become a widely used treatment for weight loss and reducing the risk of type 2 diabetes in people with obesity.
What could go wrong
This is a large real-world study, but results may vary across individuals. Tirzepatide can cause side effects like nausea or vomiting, and long-term safety is still being monitored.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 3,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Jul 2032

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a body mass index ≥30 and ≤34.9 kilogram per square meter (kg/m2) * Have an increased waist to height ratio (defined by \>0.5) * Have at least one weight related comorbid condition * Have had at least one attempt to lose weight with lifestyle intervention (diet and physical activity) Exclusion Criteria: * Have type 1 diabetes, type 2 diabetes, or any other types of diabetes * Have had a change in body weight of greater than 5 kilograms (11 pounds) within 90 days prior to screening

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight type 2 diabetes mellitus prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    30 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • P83012 Tower Family Healthcare

    NOT_YET_RECRUITING

    Bury, BL9 0NJ, United Kingdom

  • P83025 St Gabriels Medical Centre

    NOT_YET_RECRUITING

    Manchester, M25 0HT, United Kingdom

  • P84012 Northenden Group Practice

    NOT_YET_RECRUITING

    Manchester, M22 4DH, United Kingdom

  • P84017 Ladybarn Group Practice

    NOT_YET_RECRUITING

    Manchester, M20 4SS, United Kingdom

  • P84034 Barlow Medical Centre

    NOT_YET_RECRUITING

    Manchester, United Kingdom

  • P84035 Bodey Medical Centre

    RECRUITING

    Manchester, M14 6WP, United Kingdom

  • P84068 Chorlton Family Practice

    NOT_YET_RECRUITING

    Manchester, M21 9NJ, United Kingdom

  • P84630 The Arch Medical Practice

    RECRUITING

    Manchester, M15 5TJ, United Kingdom

  • P84678 Didsbury Medical Centre

    NOT_YET_RECRUITING

    Manchester, M20 2ER, United Kingdom

  • P85010 Woodlands Medical Practice

    RECRUITING

    Oldham, OL9 0LH, United Kingdom

  • P85011 CH Medical Practice

    RECRUITING

    Oldham, OL9 8NH, United Kingdom

  • P86004 Peterloo Medical Centre

    RECRUITING

    Manchester, M24 4DZ, United Kingdom

  • P86022 Stonefield Street Surgery

    RECRUITING

    Rochdale, OL16 4JF, United Kingdom

  • P87016 The Sides Medical Centre

    RECRUITING

    Swinton, M27 0EW, United Kingdom

  • P87019 Silverdale Medical Practice

    RECRUITING

    Manchester, M27 8 HP, United Kingdom

  • P87025 The Lakes Medical Practice

    RECRUITING

    Swinton, M27 4AF, United Kingdom

  • P87027 Langworthy Medical Practice

    RECRUITING

    Salford, M6 5WW, United Kingdom

  • P88007 Cheadle Hulme Medical Group (was Cheadle Hulme Health Centre) (Bridge House)

    NOT_YET_RECRUITING

    Cheshire, SK8 5LL, United Kingdom

  • P88632 Stockport Medical Group

    NOT_YET_RECRUITING

    Stockport, SK3 9NX, United Kingdom

  • P89002 The Brooke Surgery

    RECRUITING

    Hyde SK14, SK14 1AT, United Kingdom

  • P89008 Ashton Medical Group

    RECRUITING

    Ashton-under-Lyne, OL6 6EW, United Kingdom

  • P91006 Urmston Group Practice

    NOT_YET_RECRUITING

    Manchester, M41 8AA, United Kingdom

  • P91013 Boundary House Medical Centre

    NOT_YET_RECRUITING

    Sale, United Kingdom

  • P91014 Washway Road Medical Centre

    NOT_YET_RECRUITING

    Cheshire, M33 7SS, United Kingdom

  • P91021 Firsway Health Centre

    NOT_YET_RECRUITING

    Sale, M33 4BR, United Kingdom

  • P91604 St John's Medical Centre

    NOT_YET_RECRUITING

    Altrincham, WA14 1PF, United Kingdom

  • P92620 SSP Ince Surgery (Lower Ince)

    NOT_YET_RECRUITING

    Manchester, WN3 4NW, United Kingdom

  • Y02319 SSP Bolton General Practice

    NOT_YET_RECRUITING

    Bolton, BL1 4TH, United Kingdom

  • Y02322 SSP Leigh Family Practice

    NOT_YET_RECRUITING

    Wigen, WN7 2PE, United Kingdom

  • Y02790 SSP Bolton Medical Centre

    NOT_YET_RECRUITING

    Great Lever, BL3 6PY, United Kingdom

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Other studies related to the condition(s) this trial covers.