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Two days of arm rest may reveal why muscles weaken faster in type 2 diabetes

NCT ID NCT06750497

Knowledge-focused Sponsor: Wageningen University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study investigates how two days of forearm immobilization (keeping the arm in a cast or sling) changes the way muscles take up glucose and amino acids. Researchers will compare these effects in people with type 2 diabetes and healthy volunteers. The goal is to understand why muscle insulin sensitivity drops so quickly during short periods of inactivity, especially in those with diabetes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
forearm immobilization
What this could lead to
If successful, this could help explain why muscle weakness and insulin resistance develop quickly in people with type 2 diabetes after short periods of inactivity.
What could go wrong
This is a small, early-stage study (26 participants) that only looks at short-term effects. Results may not apply to longer periods of inactivity or to broader populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 26 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria * Males and females with or without diagnosed type 2 diabetes * Use lifestyle changes, metformin, gliclazide, or a combination thereof as oral glucose-lowering treatments for T2D * Aged 18-80 years at the time of signing informed consent * 18.5 ≥ BMI ≤ 35 kg·m2 Exclusion criteria * Type 1 or a genetic form of diabetes * Any diagnosed cardiovascular (heart) disease or high blood pressure (≥160 mmHg systolic and/or ≥100 mmHg diastolic) * Chronic use of any prescribed or over-the-counter pharmaceuticals (excluding oral contraceptives and contraceptive devices) that interact with muscle substrate metabolism (e.g. selective serotonin reuptake inhibitors) * Consumption of a low-carbohydrate diet * Smoking or chewing tobacco * Known anaemia * Regular use of dietary protein and/or amino acid supplements (\>3 times per week) * Currently involved in a structured progressive resistance training program (\>3 times per week) * A personal or family history of thrombosis (clots) * Any previous motor disorders or inborn errors in muscle and/or lipid metabolism * History of kidney disease * History of liver disease * Pregnant or breastfeeding * History of any drug or alcohol abuse in the past two years * Claustrophobia * Unable to give consent

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy Type 2 diabetes

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Wageningen University and Research

    RECRUITING

    Wageningen, Gelderland, 6708WD, Netherlands

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