Kids' flu shot study aims to make vaccines better
NCT ID NCT04963166
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how children's immune systems respond to the seasonal flu vaccine. Researchers collected nasal and finger-prick blood samples from 65 kids aged 2-17 before and after they got their flu shot. The goal was to understand both systemic and nasal immunity, which could help design more effective flu vaccines in the future.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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65 people
The number who actually took part.
- Started
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Sep 2021
- Finished
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Dec 2023
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Children receiving their first ever influenza vaccine require two doses of the vaccine one month apart and will not be included in this study. Only participants who have already received a flu vaccine series in the past will be eligible for this study. Evaluation of immunity after the first ever influenza vaccination series is an important question that should be explored separately. We will enroll participants into one of three cohorts by age: 2 6 years old, 7 11 years old, and 12 17 years old. We will aim to enroll similar numbers of participants into each group to ensure a diverse age range in our population.
- Ages
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2 to 17 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* INCLUSION CRITERIA: In order to be eligible to enroll in this study, an individual must meet all of the following criteria: * \>= 2 years of age and \< 18 years of age at the time of enrollment. * Completed a previous influenza series in the past and therefore requires only one seasonal influenza vaccine every year. * Planning to receive the current seasonal inactivated influenza vaccine given by injection. * Parent or guardian willing and able to provide verbal consent. * Willing and able to undergo home blood micro-sampling and nasal sampling. * Willing to have samples stored for future research. * Parent/guardian able to proficiently speak, read, and write English. EXCLUSION CRITERIA: Any individual who meets any of the following criteria will be excluded from participation in this study: * Already received the current season s influenza vaccine. * Planning to receive the current seasonal live attenuated influenza vaccine (LAIV). * Self-reported pregnancy or breastfeeding. * Any condition that, in the opinion of the investigator, would compromise the safety of the study participant or staff, or would prevent proper conduct of the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda, Maryland, 20892, United States