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Scientists seek answers for rare immune disorder

NCT ID NCT00006150

First seen Nov 01, 2025 · Last updated Jun 19, 2026 · Updated 44 times

Summary

This study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes severe skin and lung infections. Researchers will follow 300 patients and 300 family members over time to understand the genetic causes and health problems linked to the condition. No new treatments are being tested; the goal is to gather information to improve future care.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

combined immunodeficiency due to DOCK8 deficiency hyper-IgE recurrent infection syndrome 1, autosomal dominant immune system disorder inborn error of immunity Infections infectious disease Job Syndrome pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.