IMMUNE SYSTEM DISEASES

This study tests if a stem cell transplant can cure people with severe immune system diseases. Participants receive healthy blood stem cells from a donor to rebuild their immune system. The study includes 66 people aged 4 to 69 who have not responded to standard treatments. The g…

This study tests whether an online training and support platform can help adults with type 1 diabetes better manage their blood sugar and well-being. About 322 participants will use the platform for 12 months, either through their usual clinic or on their own. Researchers will tr…

This study tests whether an online training and peer support platform, called Support-t, can help teenagers with type 1 diabetes prepare for the move from pediatric to adult healthcare. About 200 teens aged 14-16 will either receive usual care or also get access to the platform. …

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells (the cells that make insulin) placed inside tiny capsules. The goal is to see if transplanting these cells is safe and can help adults with unstable type 1 diabetes who still have dangerous lo…

This study follows 200 people aged 12 and older with moderate-to-severe eczema who are starting a new prescription of abrocitinib. Researchers will track how much their skin improves over 12 months in real-world settings, not a controlled lab. The goal is to see how well the drug…

This study tests two treatments (emapalumab or fludarabine plus dexamethasone) to reduce inflammation before a stem cell transplant in people with primary immune regulatory disorders. The goal is to help the donated stem cells settle in and start making healthy immune cells. Abou…

This study tests whether a stem cell transplant from a healthy donor can control peripheral T-cell lymphoma in patients whose cancer hasn't responded to standard treatments. Participants receive chemotherapy or antibody therapy before the transplant to prepare their body. The goa…

This study is testing whether a stem cell transplant from a healthy donor can safely treat people with severe immune system problems. Participants (ages 4-75) receive chemotherapy and then donor stem cells, followed by a hospital stay and years of monitoring. The goal is to see i…

This study follows people with Hyper IgE Syndrome (HIES), a rare immune disorder that causes severe eczema, lung infections, and other health problems. Researchers will track up to 600 participants and their relatives over time to learn how genetic changes cause the disease and h…

This study aims to understand how eosinophils (a type of white blood cell) become active in conditions like allergies, asthma, and parasitic worm infections. Researchers will observe up to 800 people aged 1 to 100 with high eosinophil levels. No experimental treatments are offere…