INFECTIONS

This study tests a new vaccine called GNG-DE to see how well it protects against meningococcal disease (a serious infection) compared to an existing vaccine. About 240 people aged 3 to 55 will take part. Researchers will check for side effects and measure immune responses in the …

This study tests whether a special parenting program (Attachment Biobehavioral Catch-Up) can help low-income Latino children have fewer illnesses, better sleep, and healthier weight. About 260 mothers and their 9-month-old babies will take part. Half will get the parenting progra…

This study tests whether Mozobil, a drug already used in stem cell transplants, can safely and effectively raise white blood cell counts in people with WHIMS, a rare genetic condition that causes frequent infections. About 20 adults aged 18 to 75 with WHIMS and a history of sever…

This study tests a wireless, battery-powered bandage called PowerHeal™ for infected wounds. About 150 adults in Ukraine with infected traumatic wounds will either get standard care or standard care plus this bandage. Researchers will check if the bandage helps close the wound fas…

This study tests whether taking antibiotics by mouth for 6 weeks works as well as getting them through an IV for people with infected broken bones that didn't heal properly. About 250 adults will be randomly assigned to one of the two treatments, along with surgery. The goal is t…

This study tests whether a 28-day course of L-Citrulline syrup can reduce death and serious complications in children aged 1 month to 5 years who are hospitalized with fever and identified as high-risk by a rapid biomarker test. About 888 children in Mozambique and Ethiopia will …

This study tests whether adding a new drug (recombinant human plasma gelsolin) to standard care can help people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. About 600 hospitalized adults will receive either the drug o…

This study tests whether checking vancomycin levels after the very first dose and adjusting quickly can help infants with sepsis reach the right drug levels faster. About 40 infants under 90 days old will take part. The goal is to avoid dangerous delays in treating serious infect…

This study collects blood samples from 20,000 adults with infections, heart disease, blood clots, or kidney disease to help develop better diagnostic tests. Researchers will compare new test methods with standard ones to see if they are accurate and reliable. The goal is to creat…

This study tests whether giving a single 2-gram dose of azithromycin to pregnant women before they start induced labor can lower the chance of infection for both mother and baby. Researchers will enroll 400 women in their third trimester who are having labor induced for medical o…

This study tests whether an augmented reality (AR) system can safely help doctors guide needles during MRI scans. About 25 people aged 3 to 21 who need a needle procedure (like a biopsy or injection) will take part. The main goal is to see if the AR system works in at least 80% o…

This study compares a new approach to managing infections in nursing home residents with dementia against usual care. The goal is to see if the new method reduces antibiotic use and avoids stressful procedures like hospital transfers. About 750 residents aged 60 and older with de…

This study aims to develop a personalized immune score to predict severe infections in immunocompromised patients, such as those who have received stem cell or organ transplants. Researchers will measure immune cells and pathogen-specific responses before or one month after trans…

This study looks back at the medical records of 350 adults in France who had surgery for esophageal cancer between 2017 and 2024. The goal is to understand how often infections like pneumonia happen after this surgery, what factors increase the risk, and how these infections affe…

This study aims to improve how doctors care for patients with infections from heart devices like pacemakers. Researchers will set up teams to help find infections faster and start the right treatment sooner. The goal is to make sure patients get the care they need quickly, follow…

This study follows people with Hyper IgE Syndrome (HIES), a rare immune disorder that causes severe eczema, lung infections, and other health problems. Researchers will track up to 600 participants and their relatives over time to learn how genetic changes cause the disease and h…

This study looks at whether people with cystic fibrosis can collect sputum (mucus coughed up from the lungs) at home and mail it in to detect lung infections as accurately as samples taken in a clinic. The goal is to make infection monitoring easier, especially with the rise of t…

This study aims to understand how well shoulder replacements work over the long term by following up to 20,000 people for at least 10 years. Participants include those who have already had or are scheduled for shoulder replacement due to conditions like arthritis, rotator cuff te…

This study looks at a rare but dangerous infection caused by Bacillus cereus bacteria in premature newborns. Researchers will analyze the bacteria's DNA and review medical records from 40 babies to identify which genetic features are linked to higher death risk. The goal is to be…

This study aims to find out how common certain infections are among asylum seekers living in reception centers in Italy. Researchers will test 250 adults who have been in Italy for 2 to 36 months for diseases like tuberculosis, HIV, hepatitis, and parasitic infections. The goal i…

This study aims to reduce maternal sepsis, a leading cause of death in new mothers, by creating and testing a safety checklist for hospitals. Researchers will track infection rates in over 33,000 birthing people before and after the checklist is put in place. The goal is to see i…

This study will collect information from HeartMate 3 heart pumps in 150 adults to see if pump data can predict problems like bleeding, infection, or frailty. Researchers want to understand how pump readings relate to patients' quality of life and health outcomes. The goal is to h…

This early-stage study is testing how much of the antibiotic combination meropenem-pralubactam gets into the lungs of 16 healthy adults in China. Participants will receive four doses of the drug, and researchers will measure its levels in blood and lung fluids. The goal is to und…

This study is looking for new ways to quickly diagnose sepsis, a life-threatening reaction to infection, in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve early …