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New combo therapy aims to tame kidney disease without Long-Term drugs

NCT ID NCT03949855

First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 32 times

Summary

This study tests whether adding belimumab to rituximab works better than rituximab alone for people with membranous nephropathy, a kidney disease that causes protein leakage. About 58 adults will receive either the combo or rituximab alone, and researchers will check if their kidney function improves or stabilizes over two years. The goal is to find a treatment that controls the disease with fewer side effects, but it is not a cure since the immune system may still cause problems.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Columbia University Medical Center: Division of Nephrology

    RECRUITING

    New York, New York, 10032, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Johns Hopkins

    RECRUITING

    Baltimore, Maryland, 21287, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Mayo Clinic Jacksonville: Department of Nephrology and Hypertension

    RECRUITING

    Jacksonville, Florida, 32224, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Ohio State University Wexner Medical Center: Division of Nephrology

    RECRUITING

    Columbus, Ohio, 43210, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Providence Medical Research Center, Providence Health Care: Nephrology

    RECRUITING

    Spokane, Washington, 99204, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Stanford University School of Medicine: Division of Nephrology

    RECRUITING

    Stanford, California, 94305, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Email: •••••@•••••

    Contact

  • The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center:Division of Nephrology and Hypertension

    RECRUITING

    Torrance, California, 90502, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Alabama at Birmingham School of Medicine: Division of Nephrology

    RECRUITING

    Birmingham, Alabama, 35294, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Arkansas

    RECRUITING

    Little Rock, Arkansas, 72205, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of California San Francisco

    RECRUITING

    San Francisco, California, 94146, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Colorado

    RECRUITING

    Aurora, Colorado, 80045, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Miami Miller School of Medicine, Div of Nephrology

    RECRUITING

    Miami, Florida, 33136, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48104, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of Minnesota Health Clinical Research Unit

    RECRUITING

    Minneapolis, Minnesota, 55455, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Nebraska

    RECRUITING

    Omaha, Nebraska, 68198, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University of North Carolina School of Medicine: Division of Nephrology and Hypertension, Kidney Center

    RECRUITING

    Chapel Hill, North Carolina, 27599-, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Pennsylvania: Department of Medicine: Renal-Electrolyte and Hypertension Division

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Washington University in St. Louis

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.