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Massive pain trial aims to find new relief options

NCT ID NCT05986292

Symptom relief Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 18, 2026 · Updated 3 times

Summary

This Phase 2 trial is testing four experimental drugs (taken orally or by IV) against placebo in 10,000 people with chronic pain from knee osteoarthritis, diabetic nerve damage, or low-back pain. The goal is to see if any of these drugs can safely reduce pain. The study uses a flexible 'master protocol' so new drugs can be added over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
LY3016859, LY3556050, LY3526318, LY3857210 (experimental drugs)
What this could lead to
If any of these drugs work, it could point toward new treatment options for chronic pain conditions like knee arthritis, diabetic nerve pain, or back pain.
What could go wrong
This is an early Phase 2 trial testing multiple drugs at once, so many may fail to show benefit. The study is large but still exploratory, and side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 10,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2020

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * have a visual analog scale (VAS) pain value ≥40 and \<95 at screening and prerandomization screening. * have a history of daily pain for at least 12 weeks based on participant report or medical history * have a value of ≤30 on the pain catastrophizing scale * are willing to maintain a consistent regimen of any ongoing nonpharmacologic pain-relieving therapies (for example, physical therapy) and/or nutritional supplements and will not start any new nonpharmacologic pain-relieving therapies and/or nutritional supplements during study participation * are willing to discontinue all medications taken for chronic pain conditions, except rescue medication for the duration of the study Exclusion Criteria: * have second- or third-degree atrioventricular (AV) heart block or AV dissociation or history of ventricular tachycardia * have had a procedure within the past 6 months intended to produce permanent sensory loss in the target area of interest (for example, ablation techniques) * have surgery planned during the study for any reason, related or not to the disease state under evaluation. * have, in the judgment of the investigator, an acute, serious, or unstable medical condition or a history or presence of any other medical illness that would preclude study participation. * have had cancer within 2 years of baseline, except for cutaneous basal cell or squamous cell carcinoma resolved by excision. * have fibromyalgia * have any clinically important abnormality at screening, as determined by investigator, in physical or neurological examination, vital signs, electrocardiogram (ECG), or clinical laboratory test results that could be detrimental to the participant or could compromise the study. * have a positive human immunodeficiency virus (HIV) test result at screening * have a history of alcohol, illicit drug, analgesic or narcotic use disorder within 2 years prior to screening.

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Conditions

The condition(s) this trial relates to.

diabetic neuropathy osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic low-back pain Diabetic neuropathic pain Osteoarthritis, knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    42 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Accel Research Sites - DeLand Clinical Research Unit

    RECRUITING

    DeLand, Florida, 32720, United States

  • ActivMed Practices and Research

    COMPLETED

    Methuen, Massachusetts, 01844, United States

  • Alliance for Multispecialty Research, LLC

    COMPLETED

    Tempe, Arizona, 85281, United States

  • Altoona Center For Clinical Research

    RECRUITING

    Duncansville, Pennsylvania, 16635, United States

  • Arizona Research Center

    RECRUITING

    Phoenix, Arizona, 85053, United States

  • Artemis Institute for Clinical Research

    RECRUITING

    Riverside, California, 92503, United States

  • Artemis Institute for Clinical Research

    RECRUITING

    San Diego, California, 92123, United States

  • Aventiv Research Inc

    COMPLETED

    Columbus, Ohio, 43213, United States

  • Boston Clinical Trials

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02131, United States

  • Bradenton Research Center, Inc.

    RECRUITING

    Bradenton, Florida, 34205, United States

  • CMR of Greater New Haven

    RECRUITING

    Hamden, Connecticut, 06517, United States

  • Cedar Health Research

    COMPLETED

    Dallas, Texas, 75251, United States

  • Central Research Associates

    RECRUITING

    Birmingham, Alabama, 35205, United States

  • Charter Research - Lady Lake

    RECRUITING

    The Villages, Florida, 32162, United States

  • Clinical Research Center of Reading,LLC

    COMPLETED

    Wyomissing, Pennsylvania, 19610, United States

  • Clinical Research of South Florida

    NOT_YET_RECRUITING

    Coral Gables, Florida, 33134, United States

  • Clinvest Research LLC

    RECRUITING

    Springfield, Missouri, 65807, United States

  • Coastal Carolina Research Center

    COMPLETED

    North Charleston, South Carolina, 29405, United States

  • Conquest Research

    RECRUITING

    Winter Park, Florida, 32789, United States

  • Cotton O'Neil Clinical Research Center - Central Office

    COMPLETED

    Topeka, Kansas, 66606, United States

  • DelRicht Research

    RECRUITING

    New Orleans, Louisiana, 70115, United States

  • DelRicht Research

    RECRUITING

    Tulsa, Oklahoma, 74133, United States

  • Desert Oasis Healthcare Medical Group

    RECRUITING

    Palm Springs, California, 92262, United States

  • Flourish Research - Miami, LLC

    RECRUITING

    Miami, Florida, 33135, United States

  • FutureSearch Trials of Neurology

    RECRUITING

    Austin, Texas, 78731, United States

  • Great Lakes Research Group, Inc.

    RECRUITING

    Bay City, Michigan, 48706, United States

  • Irvine Clinical Research

    COMPLETED

    Irvine, California, 92614, United States

  • K2 MEDICAL Research THE VILLAGES

    RECRUITING

    Lady Lake, Florida, 32159, United States

  • K2 Medical Research ORLANDO

    RECRUITING

    Maitland, Florida, 32751, United States

  • Latin Clinical Trial Center

    COMPLETED

    San Juan, 00909, Puerto Rico

  • Lillestol Research

    RECRUITING

    Fargo, North Dakota, 58104, United States

  • Lucida Clinical Trials

    RECRUITING

    New Bedford, Massachusetts, 02740, United States

  • META Medical Research Institute

    RECRUITING

    Dayton, Ohio, 45432, United States

  • Martin E. Hale M.D., P.A.

    COMPLETED

    Plantation, Florida, 33317, United States

  • MedVadis Research Corporation

    RECRUITING

    Waltham, Massachusetts, 02451, United States

  • Merritt Island Medical Research, LLC

    RECRUITING

    Merritt Island, Florida, 32952, United States

  • New Horizon Research Center

    RECRUITING

    Miami, Florida, 33165, United States

  • North Georgia Clinical Research

    RECRUITING

    Woodstock, Georgia, 30189, United States

  • Northwest Clinical Research Center

    RECRUITING

    Bellevue, Washington, 98007, United States

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

  • PharmQuest

    COMPLETED

    Greensboro, North Carolina, 27408, United States

  • Ponce Medical School Foundation Inc.

    RECRUITING

    Ponce, 00716, Puerto Rico

  • Precision Clinical Research

    RECRUITING

    Sunrise, Florida, 33351, United States

  • Rainier Clinical Research Center

    RECRUITING

    Renton, Washington, 98057, United States

  • Re:Cognition Health - Fort Worth

    RECRUITING

    Fort Worth, Texas, 76104, United States

  • Renstar Medical Research

    RECRUITING

    Ocala, Florida, 34470, United States

  • Rochester Clinical Research, LLC

    RECRUITING

    Rochester, New York, 14609, United States

  • Rocky Mountain Clinical Research

    NOT_YET_RECRUITING

    Idaho Falls, Idaho, 83404, United States

  • SYNEXUS

    COMPLETED

    Murray, Utah, 84123, United States

  • Simon Williamson Clinic

    COMPLETED

    Birmingham, Alabama, 35211, United States

  • StudyMetrix Research

    RECRUITING

    City of Saint Peters, Missouri, 63303, United States

  • Suncoast Clinical Research, Inc.

    RECRUITING

    New Port Richey, Florida, 34652, United States

  • Synexus

    COMPLETED

    Dallas, Texas, 75234, United States

  • Synexus - Cincinnati

    COMPLETED

    Cincinnati, Ohio, 45236, United States

  • Synexus Clinical Research

    COMPLETED

    Chicago, Illinois, 60602, United States

  • Synexus Clinical Research - Glendale

    COMPLETED

    Glendale, Arizona, 85306, United States

  • Synexus Clinical Research - St. Petersburg

    COMPLETED

    Pinellas Park, Florida, 33781, United States

  • Synexus Clinical Research US, Inc.

    RECRUITING

    Phoenix, Arizona, 85020, United States

  • Synexus Clinical Research US, Inc.

    NOT_YET_RECRUITING

    Orlando, Florida, 32806, United States

  • Synexus Clinical Research US, Inc.

    COMPLETED

    The Villages, Florida, 32162, United States

  • Synexus Clinical Research US, Inc.

    COMPLETED

    Omaha, Nebraska, 68144, United States

  • Synexus Clinical Research US, Inc.

    COMPLETED

    San Antonio, Texas, 78229, United States

  • University of Miami Don Suffer Clinical Research Building

    NOT_YET_RECRUITING

    Miami, Florida, 33136, United States

  • VIN-Julie Schwartzbard

    COMPLETED

    Aventura, Florida, 33180, United States

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