CHRONIC LOW-BACK PAIN

This study tests a new device called PerQdisc, which is surgically placed in the spine after removing a damaged disc. It aims to reduce pain and improve function in people with degenerative disc disease. The trial will enroll 72 adults aged 22-70 who have not gotten relief from a…

This study tests whether adding supervised group art therapy to exercise can help older adults (60+) with chronic low back pain. Researchers will check if the program is practical and liked by participants, and look for early signs that it reduces pain and improves well-being. Th…

This study tests an experimental drug called CELZ-201-DDT, given as a shot into the back muscles, for people with long-term lower back pain due to worn-out spinal discs. The goal is to see if it is safe and can reduce pain and improve movement. About 45 adults aged 18 to 80 who h…

This study compares usual physiotherapy with a personalized approach called STOPS for people with chronic low back pain. About 154 patients will take part to see if STOPS reduces pain and disability more effectively. The goal is to find a better way to manage back pain and improv…

This study explores whether a mobile app and headset can help people with chronic low back pain by training the brain to relax. About 150 participants will use the app for 10 minutes, four times a week for three months. Researchers will check pain levels and daily function over n…

This study tests whether active music-based activities can improve thinking, pain sensitivity, and quality of life in people with chronic low back pain. About 40 adults aged 18-65 with long-term back pain will attend 5 sessions over 2 weeks. Researchers will measure changes in co…

This study tests whether adding extracorporeal shock wave therapy (ESWT) to standard physical therapy helps people with chronic low back pain feel better and move easier. About 44 adults with pain lasting over 3 months will receive either standard care alone or standard care plus…

This study looks at whether a high frequency electrical current called TECAR can reduce pain and improve flexibility in people with muscle injuries or low back pain. About 200 adults with muscle strains or back pain will receive either TECAR or a control treatment. Researchers wi…

This pilot study is testing whether ketamine infusions, followed by a brief behavioral therapy, can help veterans with chronic low back pain and depression. The study will enroll 44 veterans and measure changes in pain interference and mood. The goal is to see if this approach is…

This study tests a non-invasive device that sends electrical stimulation through the skin to the spinal cord, aiming to reduce chronic low back pain and improve movement. About 50 adults with low back pain who can stand up from a chair without help will receive the stimulation in…

This study looks at whether a single high dose of psilocybin (the active ingredient in magic mushrooms) can help people with both chronic low back pain and depression. Forty adults will receive either psilocybin or a control drug, then complete surveys and pain tests over one mon…

This study tests a new type of spinal cord stimulation (called TVP-SCS) to see if it can reduce chronic low back and leg pain by at least 50% in 70 adults. Participants must have had pain for 6 months or more and be able to complete English questionnaires. The main goal is to mea…

This study compares two treatments for chronic low back pain: a hands-on therapy that mobilizes the back's connective tissue and an ultrasound-guided injection of a sugar-water solution. The goal is to see which better reduces pain, improves movement, and enhances quality of life…

This study compares a new type of needle used in a standard pain-relief procedure (radiofrequency ablation) against usual medical care for people with long-term low back pain. About 50 adults with pain lasting at least 6 months will take part. The goal is to see if the new needle…

This study compares two treatments for adults aged 20-65 with chronic low back pain lasting at least one year: lumbar fusion surgery or a multidisciplinary rehab program. The goal is to see which approach better reduces disability and improves daily life. Participants will be ran…

This study tests whether online physical therapy sessions, tailored to each person's risk level, can reduce pain and disability in adults with chronic low back pain living in rural communities. About 434 participants will receive either personalized telerehabilitation or standard…

This study is tracking how well a commercially approved procedure called Intracept works for people with chronic low back pain caused by vertebrogenic pain syndrome. The procedure uses a device to ablate (disable) certain nerves in the spine. Researchers will measure changes in d…

This study tests a home-based program combining mindfulness meditation with a gentle nerve stimulation device for older adults (ages 50-85) who have chronic low back pain and mild to moderate depression. Over several weeks, researchers will measure changes in pain intensity, dail…

This study compares virtual reality-based rehabilitation to standard physiotherapy for 80 adults aged 40-65 with chronic low back pain lasting at least three months. Participants will do exercises with a 3D camera and real-time feedback over four weeks. Researchers will measure p…

This study looks at whether adding a behavioral weight reduction program (diet, exercise, and behavior changes) to standard back pain treatment can help overweight or obese people with chronic low back pain. About 252 adults will be split into two groups: one gets the weight prog…

This study aims to find the best non-surgical, non-drug treatments for chronic low back pain in Veterans. About 2,500 Veterans will be randomly assigned to different treatments, including online pain self-management, enhanced physical therapy, yoga, spinal manipulation, or cognit…

This study is testing whether adding osteopathic treatment (a type of hands-on therapy) to standard medical care can reduce pain in people with chronic low back pain that has lasted more than 3 months. About 199 adults will be randomly assigned to receive either standard care alo…

This study is testing several experimental treatments to ease chronic pain from knee arthritis, diabetic nerve pain, or ongoing low-back pain. Researchers will compare each treatment against a placebo to see which ones work best. The trial aims to enroll 10,000 adults who have ha…

This study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce chronic low back pain. Researchers will measure pain levels and brain activity in 80 adults aged 18-60 who have had low back pain for over 6 months. The goal is to see if tACS can c…

This study will compare physical therapy done through video visits (telerehabilitation) with in-person clinic visits for people with chronic low back pain. Researchers will enroll 1000 adults in Maryland and Utah who have had low back pain for at least 3 months. The goal is to se…

This study looks at whether adding biofeedback to standard back exercises can reduce pain and improve balance and daily function in people with chronic low back pain. About 110 adults aged 30-65 with ongoing pain will be randomly assigned to receive either standard therapy or the…

This study tests whether mindfulness meditation can reduce chronic low back pain in adults aged 50 and older. Researchers will track pain levels and explore how the gut-brain connection plays a role. 66 participants will practice meditation for 8 weeks, and the goal is to see if …

This study looks at how the brain and nerves contribute to long-term muscle and joint pain, such as arthritis, fibromyalgia, and back pain. Researchers will use a simple questionnaire and pain sensitivity tests to see if they can better diagnose and guide treatment. About 250 adu…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to see if daily changes in these factors can predict whether pain becomes long-term or flares up. A smaller group will also …

This study looks for brain signals that can predict how chronic low back pain changes over time. Researchers will use EEG, a non-invasive brain scan, to track brain activity in 130 adults with and without chronic back pain. The goal is to find patterns that could lead to better, …

This study looks at how doctors feel about using a new disposable wearable activity monitor called VERABAND™ for people with chronic low back pain. About 360 clinicians from pain clinics will rate how easy it is to use and whether they would adopt it in their practice. The goal i…

This study looks at whether people with long-term low back pain can correctly identify the source of their pain after learning about common causes. About 269 participants will review slides showing pain patterns for different conditions, then guess their top two diagnoses. Resear…

This study looks at whether brain scans can help predict which people with chronic low back pain will get good pain relief from spinal cord stimulation (SCS). Researchers will scan the brains of 42 adults before they receive SCS as part of their normal care, then check their pain…

This study aims to improve how we understand and treat low back pain by using ultrasound imaging and machine learning (a type of artificial intelligence). Researchers will compare images from people with and without back pain to find better ways to diagnose the problem. They will…

This study looks at what motivates or stops people with chronic low back pain from using a health app to stay physically active. Researchers will interview 25 adults to understand their views and needs. The goal is to learn how to design better digital tools that help patients ke…

This study looks at how a device that delivers a cold puff to the ear might help people with long-term low back pain. Researchers will use brain scans to see if this treatment changes how the brain processes pain. The study involves 60 adults who have had back pain for at least 6…

This study looks at how spinal cord stimulators affect the brains of 20 adults with chronic low back pain. Researchers will use fMRI scans to compare brain activity when the stimulator is on versus off. The goal is to find patterns that predict who will benefit most from this tre…