Chronic low back pain

This study tests two natural brain molecules as a safe, non-addictive treatment for chronic low back pain in 108 U.S. military veterans aged 18-65. The goal is to reduce pain severity and improve daily function without the risks of opioids. Participants will receive the experimen…

This Phase 3 trial tests whether combining transcranial magnetic stimulation (TMS) with yoga can ease chronic low back pain in 213 veterans. TMS uses magnetic pulses to gently stimulate brain areas involved in pain, while yoga adds stretching and strengthening. The goal is to red…

This study tests whether yoga, with or without extra coaching, can help veterans with chronic low back pain keep up a home practice and enjoy lasting pain relief and better function. About 176 veterans will take weekly yoga classes for 12 weeks, and some will also receive one-on-…

This trial tests whether different settings of lumbar vibration can change how the brain's sensory cortex responds in office workers with chronic low back pain. Participants receive eight random combinations of vibration frequency, amplitude, and direction while researchers measu…

This trial tests whether a belt that delivers gentle vibrations to the lower back can reduce chronic low back pain in office workers who sit for long hours. Researchers will compare the active belt with a sham belt that looks the same but does not vibrate. Participants wear the b…

This trial tests an online platform called Ready Set Recover, designed to help people prepare for and recover from spine surgery. The platform offers education, mindfulness, gratitude exercises, and gentle movement to support mental well-being and patient engagement. Researchers …

This study tests whether low-dose laser acupuncture can ease pain and improve daily function in adults with chronic low back pain. Researchers will compare active laser treatment to a sham (fake) laser in 80 participants. The goal is to see if this non-invasive approach offers re…

This study tests whether cognitive functional therapy (CFT) can reduce disability in people with chronic low back pain after spinal surgery. 90 adults aged 18-75 who have had surgery at least 3 months ago and still have pain will receive either CFT or a sham treatment. The main g…

This study tests whether a smartphone app that provides personalized exercises, pain management audio, and coaching can reduce activity limitations in adults with chronic low back pain. 330 participants will either use the app or continue usual care. The main goal is to see if th…

This study looks at whether adding connective tissue massage to exercise can reduce pain and improve movement, balance, and quality of life in people with chronic low back pain. About 40 adults aged 18-65 with back pain for at least 6 months will receive either real massage or a …

This pilot study will test whether the Neurolumen device—which combines low-level lasers, LEDs, and electrical stimulation—can reduce pain and painkiller use in 50 adults with chronic low back pain. Participants will use the device daily for 4 weeks, and some will receive a sham …

This study will test whether adding pain neuroscience education (learning how pain works) to standard back exercises helps people with chronic low back pain more than exercises alone. Forty adults aged 25 to 50 with pain lasting over 12 weeks will be randomly assigned to either e…

This study will test three types of physical therapy for chronic low back pain: active exercises in water, passive movements guided by a therapist in water, and standard exercises on land. Twelve adults aged 18 to 65 with pain lasting over three months will participate. The goal …

This study tests whether adding a daily physical activity program to a structured exercise routine can reduce disability and improve mental health in people aged 60 and older with chronic low back pain. One hundred participants will be split into three groups: exercise plus activ…

Researchers at Marmara University are studying why some people with chronic low back pain and nerve-related leg pain respond better than others to a standard steroid injection near the spine. The team follows 60 adults who are already scheduled for this routine procedure. Before …

Researchers at a French hospital are observing how pain perception and central sensitization change during a 40-day exercise rehabilitation program on a stationary bike. The study includes 40 adults with chronic low back pain from untreated degenerative spine disease. Participant…

Researchers at the University of Minnesota are studying why chronic pain varies so much from person to person. The study enrolls 400 adults with chronic low back pain or spinal cord injury-related neuropathic pain. Participants answer brief surveys four times a day for at least t…

This study aims to create a tool that predicts which patients are likely to have persistent pain after lumbar spine surgery, a condition known as failed back surgery syndrome. Researchers will combine routine blood tests, MRI scans, and psychological questionnaires from 150 adult…

This study will check if a virtual reality version of a common mobility test (the Timed Up and Go test) works well for people with chronic low back pain. About 65 adults aged 18 to 55 will do both the standard test and a VR version, then repeat the VR test a week later. The goal …